Post COVID-19 Vaccine Related Cerebral Venous Sinus Thrombosis and Thrombocytopenia

Manuel, William Butler-; Rana, Usman Iqbal; Zafar, Mansoor; Gadi, Azeem; Kiani, Amarah

doi:10.7759/cureus.20932

Cited by 6 publications

(8 citation statements)

References 9 publications

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“…VITT, a life-threatening emergency, has been described as a complication of adenoviral COVID-19 vaccines in the literature, although not widely reported. We have tabulated the reported cases of VITT following AstraZeneca COVID-19 vaccination in Table 2 [4][5][6][9][10][11]. The mechanism of VITT needs to be clearly defined, and it has been reported that COVID-19 vaccine-associated VITT presents 5-48 days following vaccination.…”

Section: Discussionmentioning

confidence: 99%

Cerebral Sinus Thrombosis and Immune Thrombocytopenia Post COVID-19 Vaccination: A Case Report and Narrative Review

Ali¹,

Dilibe²,

Rai³

et al. 2023

Cureus

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Vaccine-induced immune thrombocytopenia and thrombosis (VITT) following the adenoviral vector COVID-19 vaccine is a rare adverse event. Although the risk of VITT following the COVID-19 vaccine appears to be low, early diagnosis and management can be lifesaving. We present a case of VITT in a young female who presented with persistent headaches and fevers followed by anisocoria and right-sided hemiplegia. Initial imaging was unremarkable, and labs showed thrombocytopenia and elevated d-dimers. Repeat imaging revealed thrombosis in the left transverse and superior sagittal sinuses, and she was diagnosed with VITT. She received combined treatment with intravenous immunoglobulins and systemic anticoagulation, resulting in an increased platelet count and resolution of her neurological symptoms.

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Section: Discussionmentioning

confidence: 99%

Cerebral Sinus Thrombosis and Immune Thrombocytopenia Post COVID-19 Vaccination: A Case Report and Narrative Review

Ali¹,

Dilibe²,

Rai³

et al. 2023

Cureus

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“…Other neurological complications such as Bell's palsy, acute transverse myelitis, acute demyelinating polyneuropathy, and transverse myelitis were reported, especially with mRNA vaccine[ 173 ]. Cerebral venous sinus thrombosis was also described in women of childbearing age, especially with adenovector-based vaccination[ 174 ]. The importance of developing vaccine-related autoimmune reactions or diseases is related to their impact on the intake of second dose vaccination and the morbidity rate.…”

Section: Post-vaccination Autoimmune Disordersmentioning

confidence: 99%

COVID-19 disease and autoimmune disorders: A mutual pathway

Al‐Biltagi¹,

Saeed²,

Bediwy³

2022

WJM

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Coronavirus disease 2019 (COVID-19) is a real challenge for humanity with high morbidity and mortality. Despite being primarily a respiratory illness, COVID-19 can affect nearly every human body tissue, causing many diseases. After viral infection, the immune system can recognize the viral antigens presented by the immune cells. This immune response is usually controlled and terminated once the infection is aborted. Nevertheless, in some patients, the immune reaction becomes out of control with the development of autoimmune diseases. Several human tissue antigens showed a strong response with antibodies directed against many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins, such as SARS-CoV-2 S, N, and autoimmune target proteins. The immunogenic effects of SARS-CoV-2 are due to the sizeable viral RNA molecules with interrupted transcription increasing the pool of epitopes with increased chances of molecular mimicry and interaction with the host immune system, the overlap between some viral and human peptides, the viral induced-tissue damage, and the robust and complex binding between sACE-2 and SARS-CoV-2 S protein. Consequently, COVID-19 and its vaccine may trigger the development of many autoimmune diseases in a predisposed patient. This review discusses the mutual relation between COVID-19 and autoimmune diseases, their interactive effects on each other, the role of the COVID-19 vaccine in triggering autoimmune diseases, the factors affecting the severity of COVID-19 in patients suffering from autoimmune diseases, and the different ways to minimize the risk of COVID-19 in patients with autoimmune diseases.

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“…Not surprisingly, although the vaccines, in general, were massively a big relief to the stress of the people globally, and indeed did help to prevent the spread and avoidance of significant morbidity and mortality, there was an emergence of side effects. These side effects ranged from the development of rashes [ 7 ], pneumonitis [ 8 ], myositis [ 8 ], pericarditis [ 8 ], and even cerebral venous sinus thrombosis [ 9 ]. Although they were rarer occurrences, they did cause concerns about the overall effectiveness versus side effects of the new COVID-19 vaccines.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 Vaccination-Induced Cholangiopathy and Autoimmune Hepatitis: A Series of Two Cases

Zafar¹,

Gordon²,

Macken³

et al. 2022

Cureus

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The coronavirus disease 2019 (COVID-19) pandemic has been associated with significant morbidity and mortality. Following the introduction of vaccines, various side effects have been reported. Whilst those reported may be attributed to the vaccine itself, at times, it may simply incite an immunological phenomenon. We present a case series of two patients who presented with symptoms of yellowing of the eyes and the skin along with fatigue, and tiredness, following vaccination for COVID-19. The diagnosis of post COVID-19-vaccination related hepatitis is one of the fewer, less understood, yet reported side effects associated with significant morbidity. The diagnosis of COVID-19 vaccination-related cholangitis is an outcome reported here for the first time to the best of our knowledge. It was alarming that both patients did not have any significant past history of medical ailments. A prompt assessment followed by investigations including liver biopsy assisted in a timely understanding of the phenomenon with complete resolution of the symptoms.

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Post COVID-19 Vaccine Related Cerebral Venous Sinus Thrombosis and Thrombocytopenia

Cited by 6 publications

References 9 publications

Cerebral Sinus Thrombosis and Immune Thrombocytopenia Post COVID-19 Vaccination: A Case Report and Narrative Review

Cerebral Sinus Thrombosis and Immune Thrombocytopenia Post COVID-19 Vaccination: A Case Report and Narrative Review

COVID-19 disease and autoimmune disorders: A mutual pathway

COVID-19 Vaccination-Induced Cholangiopathy and Autoimmune Hepatitis: A Series of Two Cases

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