Post‐COVID pulmonary injury in K18‐hACE2 mice shows persistent neutrophils and neutrophil extracellular trap formation

Giannakopoulos, Stefanos; Park, Juwon; Pak, Jin; Tallquist, Michelle D.; Verma, Saguna

doi:10.1002/iid3.1343

Immunity Inflam & Disease

2024

DOI: 10.1002/iid3.1343

|View full text |Cite

Post‐COVID pulmonary injury in K18‐hACE2 mice shows persistent neutrophils and neutrophil extracellular trap formation

Stefanos Giannakopoulos,

Juwon Park,

Jin Pak

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Preprint1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

A Mouse-adapted SARS-CoV-2 Model for Investigating Post-acute Sequelae of COVID infection

Qiao,

Qu,

Qiu

et al. 2024

Preprint

View full text Add to dashboard Cite

The coronavirus disease of 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), remains a major health issue after nearly 7 millions of death toll in the last four years. As the world is recovering with improving vaccines and antiviral treatments, the alarming rate of long-COVID, or Post-acute Sequelae of COVID-19 (PASC), calls for further investigations. Among a list of symptoms associated with multi-organ dysfunctions, the neurological complications are particularly intriguing, yet the underlying mechanisms remain elusive. With the recently developed mouse adapted SARS-CoV-2 stain, we are now able to model the mild COVID infection in C57BL/6 mice and study the chronic immune responses and subsequent damages in different organs long after the viruses are clearly naturally in the body. More specifically, we found adult C57BL/6J mice developed neurological impairments, including behavior changes related to sensorimotor coordination, depression- and anxiety-like behaviors, and inflammation in multiple organs including lung, liver and brain, which persisted over at least 4 weeks in mice even with mild infection. Therefore, this model can be used to further explopred the mechanisms of PASC, as well as potential intervention or therapeutic approaches.

show abstract

A Mouse-adapted SARS-CoV-2 Model for Investigating Post-acute Sequelae of COVID infection

Qiao,

Qu,

Qiu

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Post‐COVID pulmonary injury in K18‐hACE2 mice shows persistent neutrophils and neutrophil extracellular trap formation

Cited by 1 publication

References 15 publications

A Mouse-adapted SARS-CoV-2 Model for Investigating Post-acute Sequelae of COVID infection

A Mouse-adapted SARS-CoV-2 Model for Investigating Post-acute Sequelae of COVID infection

Contact Info

Product

Resources

About