Post-craniotomy intracranial infection in patients with brain tumors: a retrospective analysis of 5723 consecutive patients

Shi, Zhonghua; Xu, Ming; Wang, Yongzhi; Luo, Xu‐Ying; Chen, Guang-Qiang; Wang, Xin; Wang, Tao; Tang, Mingzhong

doi:10.1080/02688697.2016.1253827

Cited by 76 publications

(67 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mortality rate of PCNSIs dropped drastically in past years, from 34% in 2005 [36] to 19% in 2011 [37], and a recent study reported that the mortality was 3.6% [16]. The mortality of present study was relatively higher than those reported, which was 21.7%.…”

Section: Discussioncontrasting

confidence: 56%

“…Microbial culture and identification remain the gold standard for diagnosing bacterial meningitis [13,14]. However, with the widespread applications of prophylactic antibiotics, the culture-positive rate of infection was relatively low, reporting from 7.5% to 50% [15][16][17]. In our study, all patients received 1.0 g cephalosporin as prophylactic therapy, which might lead to the relative lower CSF culture positive rate (29.1%).…”

Section: Discussionmentioning

confidence: 72%

See 1 more Smart Citation

A retrospective study of prevalence and antibiotic resistance of bacteria isolated from the cerebrospinal fluid of neurosurgical patients in a Shanghai tertiary hospital

Liu

Zhu

Zhou

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Postoperative central nervous system infections (PCNSIs) are serious complications following neurosurgery. Effective management of the infections depends on the identification of causative pathogens and the antibiotic sensitivities. The aim of this study was to investigate the clinical features, causative organisms and their antimicrobial susceptibility testing results, which could help clinicians to initiate appropriate empirical antibiotic therapy.Methods: This was a retrospective study conducted over a period of 3.5 years (from January 2016 to July 2019). All in-patients admitted neurosurgery and ICU meeting the inclusion criteria of PCNSIs were included in the study. Demographic characteristics, type of neurosurgery, laboratory data, causative organisms and antimicrobial susceptibility testing results were analyzed.Results: A total of 1500 patients underwent operation during this study. Twenty-three patients with 34 isolates out of 79 patients with 157 CSF culture samples were available for data analysis. The estimated incidence and culture-positive rate of PCNSIs were approximately 1.5% and 29.1%, respectively. The predominant organism was coagulase-negative staphylococci, of which most were methicillin-resistant coagulase-negative staphylococci (MRCoNS). All were susceptible to vancomycin, linezolid, and rifampicin. Acinetobacter baumannii was the most frequent causative Gram-negative agent and was resistant to 14 out of 17 antimicrobials tested. The sensitivity rates for amikacin, sulfamethoxazole-trimethoprim and minocycline were only 44, 44, and 11%, respectively.Conclusions: The MRCoNS were the predominant organism for PCNSIs. The management of Acinetobacter baumannii could be a major clinical challenge with few effective antimicrobials in PCNSIs.

show abstract

Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 72%

A retrospective study of prevalence and antibiotic resistance of bacteria isolated from the cerebrospinal fluid of neurosurgical patients in a Shanghai tertiary hospital

Liu

Zhu

Zhou

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Postoperative central nervous system infections (PCNSIs) are an uncommon but serious complication in neurosurgery, with an infection rate ranging from 4.5% to 7.4% (1,2). Due to the advent of the sterile field and prudent antibiotic use during the perioperative period, the overall mortality rate of PCNSIs has dropped drastically in the past several years, from 34% in 2005(3) to 1.8% in a recent study; however, this mortality rate is still 3.78 times that of non-PCNSI patients (2). Although most PCNSIs are caused by gram-positive bacteria, there has been a trend toward gram-negative organisms in the recent literature.…”

Section: Introductionmentioning

confidence: 99%

A combined strategy for postoperative patients with central nervous system infections caused by XDR/PDR Acinetobacter baumannii: a retrospective study

Chang

Chen

Wang

et al. 2019

Preprint

View full text Add to dashboard Cite

Background Postoperative central nervous system infections (PCNSIs) caused by extensively drug-resistant (XDR) or pandrug-resistant (PDR) Acinetobacter baumannii are rare but intractable problems. To investigate a potential combined strategy to treat AB organisms that are resistant to not only meropenem but also colistin. Methods We retrospectively reviewed cerebrospinal fluid positive culture isolates of AB in patients who underwent neurosurgery. Medical records were collected by standard forms and analyzed. Results 16 patients met the criteria and most patients were middle-aged men who had undergone craniotomy or endonasal transsphenoidal surgery. 68.8% AB isolates were XDR bacteria, and 18.8% isolates were PDR bacteria. 12 patients were treated by meropenem-based regimen strategy. Another 4 patients were administered tetracycline-based regimens. 93.8% patients were treated with therapeutic drainage, and strict hygiene rules were followed. Finally, 12 patients survived their infections, and the average Glasgow Outcome Scale score was 2.9±1.4 at discharge. And the mortality rates of carbapenem-resistant AB (CRAB) were 8.3%. Conclusions PCNSIs caused by XDR/PDR AB are a rare and serious complication. Combined therapy based on the individual situation, including appropriate antimicrobial agents, surgical management and strict hygiene management, might be an effective therapeutic strategy.

show abstract

“…However, there is still a certain percent of CCM patients having postoperative infection-related complications. These complications, including pneumonia and intracranial infection, are among the most serious and life-threatening complications after CCM surgery and are associated with poor short-and long-term outcomes 6,7 . For CCM patient with infection-related postoperative complications, a prolonged clinical course is needed.…”

mentioning

confidence: 99%

Predictive factors of postoperative infection-related complications in adult patients with cerebral cavernous malformations

Ding

Lian

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Materials and Methods Study population. Information of CCM patients admitted between January 2010 and December 2017 to the Department of Neurosurgery of the First Affiliated Hospital of Fujian Medical University was retrospectively reviewed. A total of 167 patients were included, the average age of patients was 39.69 ± 15.27 years, with 43.1% (72/167) being female. The inclusion criteria were: (1) Age >18 years old; (2) diagnosed with CCM based on preoperative imaging, treated with surgery and confirmed with CCM based on postoperative pathological result. Exclusion criteria were: (1) Patient with incomplete disease information, such as missing any of the following: assessment of disease severity (including GCS, KPS and mRS) and WBC differential count (including the WBC count, neutrophil (NEU) count and lymphocyte (LYM) count) at admission, imaging and pathological information, and information on postoperative complications; (2) the patient had any type of surgery or acute or chronic infection within the past month; (3) prior onset of other neurological diseases such as intracranial tumors, stroke or severe head trauma; (4) patient had previous CCM surgery; (5) previous use of immunosuppressants; (6) other systemic diseases, such as autoimmune disease, uremia, cirrhosis, cancer, and chronic lung and heart diseases. The study conformed to the ethical guidelines of the Declaration of Helsinki. The local Ethics Committee of the First Affiliated Hospital of Fujian Medical University (Fujian, China) approved this study and waived the requirement for informed consent because of its retrospective design.

show abstract

Post-craniotomy intracranial infection in patients with brain tumors: a retrospective analysis of 5723 consecutive patients

Abstract: Risk factors for PCII can be identified early in the perioperative period. These findings raise the possibility of improving the clinical outcomes of patients with brain tumors who undergo craniotomy.

Cited by 76 publications

References 25 publications

A retrospective study of prevalence and antibiotic resistance of bacteria isolated from the cerebrospinal fluid of neurosurgical patients in a Shanghai tertiary hospital

A retrospective study of prevalence and antibiotic resistance of bacteria isolated from the cerebrospinal fluid of neurosurgical patients in a Shanghai tertiary hospital

A combined strategy for postoperative patients with central nervous system infections caused by XDR/PDR Acinetobacter baumannii: a retrospective study

Predictive factors of postoperative infection-related complications in adult patients with cerebral cavernous malformations

Contact Info

Product

Resources

About