Post-Critical Period Transcriptional and Physiological Adaptations of Thalamocortical Connections after Sensory Loss
Laxmi Iyer,
Kory Johnson,
Sean Collier
et al.
Abstract:Unilateral whisker denervation activates plasticity mechanisms and circuit adaptations in adults. Single nucleus RNA sequencing and multiplex fluorescence in situ hybridization revealed differentially expressed genes related to altered glutamate receptor distributions and synaptogenesis in thalamocortical (TC) recipient layer 4 (L4) neurons of the sensory cortex, specifically those receiving input from the intact whiskers after whisker denervation. Electrophysiology detected increased spontaneous excitatory ev… Show more
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