Post-dexamethasone serum copeptin corresponds to HPA axis responsiveness in human obesity

Schinke, Christian; Hesse, Swen; Stoppe, Muriel; Meyer, Kara; Schmidt, Elisa; Orthgieß, Johannes; Bechmann, Lukas; Bresch, Anke; Rullmann, Michael; Luthardt, Julia; Sabri, Osama; Blüher, Matthias; Kratzsch, Jürgen; Bergh, Florian Then

doi:10.1016/j.psyneuen.2017.01.004

Cited by 11 publications

(20 citation statements)

References 54 publications

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“…Copeptin levels correlated negatively with BMI in our study; as BMI increased, copeptin plasma concentrations decreased. In another study, a positive correlation between copeptin levels and BMI was observed in obese males, but not in women and non-obese controls (Schinke et al, 2017 ).…”

Section: Discussionmentioning

confidence: 93%

“…Exploratory analyses revealed a negative correlation between copeptin levels and cortisol increase (measured by BtP and AUC values in the combined dexamethasone/CRH stimulation test). Schinke et al ( 2017 ) found that copeptin levels (after dexamethasone) correlated positively with ACTH and cortisol release in obese males but not in females.…”

Section: Discussionmentioning

confidence: 99%

“…Administration of the panicogenic peptide cholecystokinin-tetrapeptide (CCK-4) induced copeptin release, which correlated with panic symptoms and secretion of ACTH and cortisol in non-obese men (mean age: 27.4 years) (Demiralay et al, 2017 ). In another study, Schinke et al ( 2017 ) measured copeptin after dexamethasone administration and before CRH administration in the combined dexamethasone/CRH stimulation test . Copeptin levels were higher in obese subjects (mean age: 36.5 ± 10.0 years; body mass index (BMI): 41.5 ± 4.7 kg/m 2 ) than normal-weight controls after dexamethasone administration.…”

Section: Introductionmentioning

confidence: 99%

“…In the obese group, copeptin correlated positively with BMI, but not with age. Moreover, copeptin serum concentrations correlated positively with ACTH and cortisol curve indicators in obese men but not in non-obese controls and females, suggesting an interaction of the AVP system with HPA activation in obese men (Schinke et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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No association between major depression with and without childhood adversity and the stress hormone copeptin

Kaczmarczyk

Spitzer

Wingenfeld

et al. 2020

European Journal of Psychotraumatology

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Background: Adverse childhood experiences (ACE) are associated with an increased risk of major depressive disorder (MDD) and hypothalamic-pituitary-adrenal (HPA) axis dysregulation. Within the HPA axis, corticotropin-releasing hormone and vasopressin (AVP) synergistically stimulate the release of adrenocorticotropic hormone, which promotes cortisol release. The cleavage product copeptin is produced during AVP synthesis and is a surrogate marker of AVP release. Children with ACE and young adults with depressive symptoms have higher levels of copeptin than healthy controls. Objective: To uncover the effects of MDD and ACE on copeptin levels in adult females. Methods: We recruited 94 women (mean age: 34.0 ± 3.6 years): 23 with MDD and ACE, 24 with MDD without ACE, 22 with ACE without MDD, and 25 healthy controls. ACE was defined as repeated sexual or physical abuse at least once a month over at least one year before the age of 18 years. MDD was defined by the DSM-IV criteria. Copeptin plasma levels were measured with an immunoluminometric assay. Results: The four groups did not differ in demographic variables. We found a significant negative correlation between body mass index (BMI) and copeptin plasma levels (r = −.21; p = .045). Copeptin plasma levels did not differ between the four groups after controlling for BMI. Conclusion: Neither MDD nor ACE was associated with altered plasma copeptin levels. Thus, copeptin does not seem to play a major role in MDD and ACE in adult females.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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No association between major depression with and without childhood adversity and the stress hormone copeptin

Kaczmarczyk

Spitzer

Wingenfeld

et al. 2020

European Journal of Psychotraumatology

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“…A previous study has indicated that CPP mirrors individual stress levels even more subtly than circulating cortisol 1. This new biomarker can enable early decision making in clinical practice and also provide a reliable degree of correlation with various acute disease states, such as cerebrovascular event,2 myocardial infarction3 or pneumonia,4 kidney disease and hypertension,5 osmotic alterations,6 human obesity,7 bipolar disorder,8 major depression,9 and childhood maltreatment 10. In triage of chest pain patients, determination of CPP, in addition to troponin, improves early diagnostic performance, especially after the onset of chest pain 11.…”

Section: Introductionmentioning

confidence: 92%

<p>A sensitive and rapid chemiluminescence immunoassay for point-of-care testing (POCT) of copeptin in serum based on high-affinity monoclonal antibodies via cytokine-assisted immunization</p>

Wang

Dzakah

Kang

et al. 2019

IJN

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Purpose: Antibodies are key reagents in the development of immunoassay. We attempted to develop high-performance CPP immunoassays using high-affinity monoclonal antibodies prepared via cytokine-assisted immunization. Methods: We used fetal liver tyrosine kinase 3 ligand (Flt3L), CC subtype chemokine ligand 20 (CCL20), and granulocyte-macrophage colony-stimulating factor (GM-CSF) to assist traditional subcutaneous immunization of preparing high-affinity monoclonal antibodies, and further to develop high-performance immunoassay methods for CPP. Results: This novel immune strategy significantly enhanced immune response against CPP. Six anti-CPP monoclonal antibodies (mAbs) with high affinity were successfully screened and selected for application in a fully automated magnetic chemiluminescence immunoassay (CLIA). This robust and rapid assay can efficiently detect CPP in the range of 1.2–1250 pmol L –1 with a detection limit of 6.25 pmol L –1 . Significantly, the whole incubation process can be completed in 30 min as compared to about 4.5 hr for the control ELISA kit. Furthermore, this assay exhibited high sensitivity and specificity, low intra-assay and inter-assay coefficients of variation (CVs < 15%). The developed assay was applied in the detection of CPP in 115 random serum samples and results showed a high correlation with data obtained using a commercially available ELISA kit (correlation coefficient, 0.9737). Conclusion: Our assay could be applied in the point-of-care testing of CPP in the serum samples, and also the method developed in this study could be adopted to explore the detection and diagnosis of other biomarkers for various diseases.

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Measurement of a Surrogate Biomarker for Arginine Vasopressin Secretion in Association with Physiometric and Molecular Biomarkers of Aging

Guest

Bernstein

Dobrowolny

et al. 2020

Methods in Molecular Biology

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Post-dexamethasone serum copeptin corresponds to HPA axis responsiveness in human obesity

Cited by 11 publications

References 54 publications

No association between major depression with and without childhood adversity and the stress hormone copeptin

No association between major depression with and without childhood adversity and the stress hormone copeptin

<p>A sensitive and rapid chemiluminescence immunoassay for point-of-care testing (POCT) of copeptin in serum based on high-affinity monoclonal antibodies via cytokine-assisted immunization</p>

Measurement of a Surrogate Biomarker for Arginine Vasopressin Secretion in Association with Physiometric and Molecular Biomarkers of Aging

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