Seismic consequences estimation for individual buildings is valuable for various stakeholders, including government entities, building owners, and insurers. The robustness of estimation results in the presence of incomplete input information can typically be investigated through sensitivity analysis. However, the estimation process's complexity and the sensitivity analysis's computational burden hinder its practical application, which requires a more efficient procedure to facilitate broader use. This paper proposes a novel framework for sensitivity analysis of seismic consequences estimation to improve the efficiency and reliability of such analysis. The proposed approach encompasses three key components: (1) stochastic ground motion modeling (SGMM)‐based seismic consequences estimation to evaluate the economic, environmental, and social consequences given specific buildings by considering different hazard levels, (2) the training of surrogate model (Gaussian process model) for structural analysis to reduce the computational cost of the evaluation process, and (3) variance‐based global sensitivity analysis to investigate the importance of parameters of concern in the estimation process. The entire procedure is implemented in Python, adhering to object‐oriented programming, and does not rely on external software. Then, the proposed methodology is applied to two distinct three‐story steel moment‐resistant frames (SMRFs) subjected to four different hazard levels to demonstrate its effectiveness. The SGMM method can generate specific ground motions for each hazard level, mitigating the potential for result bias from using ground motions with unrealistic characteristics. Furthermore, the SGMM method is particularly suitable for automated analysis processes reducing the laborious task of screening ground motions from the database. Comparative analysis with surrogate‐free estimation reveals that the surrogate‐based analysis delivers reliable results with significantly reduced computational cost. The results of analyzing different structures under varying hazard levels reflect the variability in sensitivity analysis of consequences estimation, highlighting the necessity of the proposed flexible and efficient framework. Furthermore, the proposed framework's advantages, limitations, and future research needs are discussed.