Post-exercise facilitation and depression of motor evoked potentials to transcranial magnetic stimulation: a study in multiple sclerosis

Perretti, A.; Balbi, Pietro; Orefice, G; Trojano, Luigi; Marcantonio, Lucia; Morra, V. Brescia; Ascione, Serena; Manganelli, Fiore; Conte, Giovanni; Santoro, Lucio

doi:10.1016/j.clinph.2004.03.028

Cited by 53 publications

(50 citation statements)

References 26 publications

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“…[2627] Conduction block,[2829] and activity dependent conduction block are also considered to be the mechanisms responsible for fatigue in MS patients. [30] Cytokine mechanism with increased level of tumor necrosis factor-α levels and interferon-γ levels are found in fatigued MS patients compared to non-fatigued patients and considered to be responsible for fatigue.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of fatigue in patients with multiple sclerosis and its effect on the quality of life

Nagaraj¹,

Taly

Gupta³

et al. 2013

Journal of Neurosciences in Rural Practice

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Objective:This prospective study was carried out to observe the prevalence of fatigue in patients with multiple sclerosis (MS) and its effect on quality-of-life (QoL).Study Design and Setting:Prospective observational study in a University Tertiary Research Hospital in India.Patients and Methods:A total of 31 patients (25 females) with definite MS according to McDonald's criteria presented in out-patient/admitted in the Department of Neurology (between February 2010 and December 2011) were included in the study. Disease severity was evaluated using the Kurtzke's expanded disability status scale (EDSS). Fatigue was assessed using Krupp's fatigue severity scale (FSS). QoL was assessed by the World Health Organization QoL-BREF questionnaire.Results:The mean age of patients was 30.1 ± 9.1 years. The mean age at first symptom was 25.23 ± 6.4 years. The mean number of relapses was 4.7 ± 3.6 in the patients. The mean duration of illness was 4.9 ± 4.4 years. The mean EDSS score was 3.5 ± 2.2. Mean fatigue score was 38.7 ± 18.5 (cut-off value 36 in FSS). The prevalence of fatigue in patients with MS was 58.1% (18/31). MS patients with fatigue were significantly more impaired (P < 0.05) on all QoL domains (i.e., physical, psychosocial, social, and environment) than MS patients without fatigue.Conclusion:Prevalence of fatigue was found to be high in the MS patients in the study. All four domains of QoL were significantly more impaired in the group with fatigue than in those without fatigue.

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Section: Discussionmentioning

confidence: 99%

Prevalence of fatigue in patients with multiple sclerosis and its effect on the quality of life

Nagaraj¹,

Taly

Gupta³

et al. 2013

Journal of Neurosciences in Rural Practice

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“…These studies suggest that the enhanced MEP amplitude following repetitive contractions may reflect changes in the central adaptive processes of intracortical circuits. 27,36 The SEM and MDC 95 values for each TMS outcome measure (TABLE 2) provide the absolute reliability of the measurement. As noted in the Methods section, a change that falls within 2 SEM between any 2 tests is probably due to measurement noise introduced by the TMS system.…”

Section: Discussionmentioning

confidence: 99%

Method for Assessing Brain Changes Associated With Gluteus Maximus Activation

Fisher

Lee²,

Pitsch³

et al. 2013

J Orthop Sports Phys Ther

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T T RESULTS:It is feasible to measure the CE of the gluteus maximus with TMS. The intraclass correlation coefficients for all TMS outcome measures ranged from 0.73 to 0.97. The ranges of minimal detectable change, with respect to mean values for each TMS variable, were larger for MEP amplitude (304.7-585.4 µV) compared to those for cortical silent period duration (25.3-40.8 milliseconds) and MEP latency (1.1-2.1 milliseconds). T T CONCLUSION:The present study demonstrated a feasible method for using TMS to measure CE of the gluteus maximus. Small minimal detectable change values for the cortical silent period and MEP latency provide a reference for future studies.

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“…In healthy subjects, MEP amplitude increases during a fatiguing exercise and reduces after its end (35). In MS patients, results are more variable because some studies reported a decrease of MEP amplitude similar to healthy subjects (36,37), while others reported an increase (19,38) or no changes (39). Also, in the premovement phase, a significant lack of MEP facilitation after a sustained motor task was shown in fatigued PwMS compared to controls and not-fatigued patients (40,41), suggesting a disruption of the brain networks involved in motor preparation which has been correlated to structural and functional changes in frontal-thalamic pathways (41).…”

Section: Neurophysiology As Investigating Tool For the Pathogenic Mecmentioning

confidence: 99%

“…Most studies reported that MS patients present lower strength values of maximal voluntary contraction (MVC) in comparison to healthy subjects (17)(18)(19)(20), and the decrease of these values is positively correlated with fatigue perception (21). The fall of muscle force (and MVC as well) could be related to a submaximal voluntary drive, which is known as central activation failure (CAF) (9).…”

Section: Neurophysiology As Investigating Tool For the Pathogenic Mecmentioning

confidence: 99%

The Potential Role of Neurophysiology in the Management of Multiple Sclerosis-Related Fatigue

et al. 2020

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Fatigue is a very common symptom among people with multiple sclerosis (MS), but its management in clinical practice is limited by the lack of clear evidence about the pathogenic mechanisms, objective tools for diagnosis, and effective pharmacological treatments. In this scenario, neurophysiology could play a decisive role, thanks to its ability to provide objective measures and to explore the peripheral and the central structures of the nervous system. We hereby review and discuss current evidence about the potential role of neurophysiology in the management of MS-related fatigue. In the first part, we describe the use of neurophysiological techniques for exploring the pathogenic mechanisms of fatigue. In the second part, we review the potential application of neurophysiology for monitoring the response to pharmacological therapies. Finally, we show data about the therapeutic implications of neurophysiological techniques based on non-invasive brain stimulation.

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Post-exercise facilitation and depression of motor evoked potentials to transcranial magnetic stimulation: a study in multiple sclerosis

Cited by 53 publications

References 26 publications

Prevalence of fatigue in patients with multiple sclerosis and its effect on the quality of life

Prevalence of fatigue in patients with multiple sclerosis and its effect on the quality of life

Method for Assessing Brain Changes Associated With Gluteus Maximus Activation

The Potential Role of Neurophysiology in the Management of Multiple Sclerosis-Related Fatigue

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