Post-exposure prophylaxis (PEP) of rabies-infected Indian street dogs

Manickam, R.; Basheer, M.D.; Jayakumar, R.

doi:10.1016/j.vaccine.2008.09.053

Cited by 15 publications

(13 citation statements)

References 21 publications

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“…Similar observations of peak antibody titre during 3-6 weeks post vaccination and waning of antibody titre were made earlier (Aubert, 1992;Oliveira et al, 2000;Manickam et al, 2008;Minke et al, 2009). Although reduction in the antibody response on the day 90 was expected, it's reduction below 0.5 IU in case of 3 animals was unexpected.…”

Section: Resultssupporting

confidence: 82%

“…Although on 90 dpv, the virus neutralizing titers irrespective of the vaccine used appeared to be waning, it is likely that the immunity thus stimulated would last for a much longer period. Manickam et al (2008) challenged dogs intramuscularly with virulent rabies virus brain suspension and injected intramuscularly with either Nobivac Rabies (Intervet), Rabisin (Merial) or placebo on multiple occasions (3 or 5-times) over the next 28 days. They recorded the serum antibody production after 3 days of post vaccination with maximum antibody titre seen on 28th dpv in dogs.…”

Section: Resultsmentioning

confidence: 99%

“…However, there are scanty reports on post exposure prophylactic vaccination trials in canines and other livestock including bovines (Basheer et al, 1997;Hanlon et al, 2002;James et al, 2007;Manickam et al, 2008). Post exposure treatment in animals is still controversial despite the fact that it has been practiced on large scale in certain situations in developed countries (Clark & Wilson, 1996).…”

Section: Introductionmentioning

confidence: 99%

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Sero monitoring of anti rabies vaccinal antibodies to pep in animals by RFFIT - a case study in Karnataka

KM¹,

Isloor²,

C³

et al. 2016

JEBAS

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KEYWORDS RabiesPost exposure prophylaxis Neutralizing antibodies Animals RFFIT ABSTRACTA dog suspected to be affected with rabies attacked 31 animals in Kesarahatti village of Gangavathi taluk, Koppal District in Karnataka on 14 th June 2015. Of these, 26 animals (14 cattle, 5 buffaloes and 7 dogs) were given the first aid followed by post exposure anti rabies vaccine at 1 (15 th June 2015), 3, 7, 14 and 28 days interval whereas the remaining 5 animals (2 cattle and 3 buffaloes) reportedly died of suspected (based on clinical manifestation) rabies after 8 days of dog bite episode. These 5 animals were not provided first aid and post exposure prophylactic (PEP) vaccination as their exposure to the rabid dog bite went unnoticed. Further, the serum samples could be collected from only 21 out of 26 vaccinated animals on 28 th and 90 th day post vaccination. These serum samples were tested by Rapid Fluorescent Focus Inhibition Test (RFFIT) and the titre of neutralizing antibodies ranged from 1-8 IU/ml from the serum collected on 28 th day post vaccination indicating protection in all the vaccinated animals. But the titre ranged from 0.5-4 IU/ml in 18 animals and less than 0.5 IU/ml in three animals (2 cows and a dog) on 90 th day post vaccination. The protective level of neutralizing antibody titre on day 28 post vaccination and non-development of disease suggests that the PEP vaccination could be effective in livestock avoiding euthanasia and culling of animals.

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Section: Resultssupporting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sero monitoring of anti rabies vaccinal antibodies to pep in animals by RFFIT - a case study in Karnataka

KM¹,

Isloor²,

C³

et al. 2016

JEBAS

View full text Add to dashboard Cite

show abstract

“…152 The harsh nature of this has led to consideration of PEP protocols for pets. 155 Based on the size of these studies and the confl icting results, plus the signifi cant public health concerns regarding rabies, there is no clear answer about PEP in pets. 154 Another study using experimentally challenged dogs indicated that vaccination of dogs on days 0, 3, 7, and 28, or on days 0, 5, and 28 prevented rabies.…”

Section: Management Of P Ets That May Have Been E Xposed To R Abiesmentioning

confidence: 99%

Viral Diseases

Weese

Fulford

2010

Companion Animal Zoonoses

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“…Vaccination of animals is also an effective way to control virus circulation in the reservoir population [4]. These preventive efforts, however, are expensive, imposing a substantial economic burden on health systems [5]. Annually, around 10 million people receive PEPs [6].…”

Section: Introductionmentioning

confidence: 99%