Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial

Molina, Jean‐Michel; Charreau, Isabelle; Chidiac, Christian; Pialoux, Gilles; Cua, Éric; Delaugerre, Constance; Capitant, Catherine; Castro, Daniela Rojas; Fonsart, Julien; Berçot, Béatrice; Bebear, Cécile; Cotte, Laurent; Robineau, Olivier; Raffi, François; Charbonneau, P.; Aslan, Alexandre; Chas, Julie; Niedbalski, Laurence; Spire, Bruno; Sagaon-Teyssier, Luis; Carette, Diane; Mestre, Soizic Le; Doré, Véronique; Meyer, Laurence; Pintado, Claire; Loze, Bénédicte; Gatey, Caroline; Ponscarme, Diane; Penot, Pauline; Veron, R; Delgado, Jean-Paul; Dallé, Ernest; Parlier, S; Madelaine, Isabelle; Danet, Marie; Mahjoub, Nadia; Mezreb, N; Moudachirou, K; Morel, Stéphane; Conort, G; Lorho, F; Meunier, M; Rozenbaum, Willy; Monfort, Christine; Foucoin, J; Boissavy, B; Cousseau, S; Huon, S; Djessima, A; Berrebi, V; Adda, Anne; Nagat, S. Le; Zarka, L; Berdougo, J; Mzoughi, N; Clement, F; Decouty, A; Chapolard, C; Godinot, Matthieu; Adouard-groslafeige, C.; Koffi, J.; Pansu, Aymeric; Becker, Ana; Pailhes, S; Bonnet, Fabrice; Jeanblanc, François; Brochier, C; Teruin, X; Rouby, Soumaya El; Gilly, L; Etienne, C; Tolonin, F; Bréaud, S; Péchenot, V; Bagge, Selena Le; Cepitelli, T; Roger, P.; Rosenthal, Elizabeth M.; Chéret, Antoine; Cornavin, Pauline; Vandamme, Sarah; Lambec, J; Dumon, N; Leclanche, O; Huleux, Thomas; Biekre, R; Melliez, H.; Bazus, H; Pasquet, A.; Bernaud, C; Besnier, Michel; Bonnet, B.; Hall, Nolwenn; Cavellec, M; Hüe, H.; Larmet, L.; Colas, M.; Choquet, Rémy; Fouéré, S.; Netzer, Emmanuelle; Lucas, Nicolás; Binesse, J; Foubert, V; Saouzanet, M; Euphrasie, F; Guillon, B; Saïdi, Yacine; Suzan, M; Cattin, G; Démoulin, Baptiste; Lorente, Nicolas

doi:10.1016/s1473-3099(17)30725-9

Cited by 253 publications

(188 citation statements)

References 27 publications

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“… and Molina et al . have reported the successful use of doxycycline prophylaxis to reduce the incidence of syphilis and chlamydia in high risk MSM. Doxycycline was not effective for prevention of gonorrhoea.…”

Section: Discussionmentioning

confidence: 99%

Sexually transmitted infections and HIV in the era of antiretroviral treatment and prevention: the biologic basis for epidemiologic synergy

2019

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Introduction HIV is a unique sexually transmitted infection (STI) that is greatly affected by other concomitant “classical” bacterial and viral STIs that cause genital ulcers and/or mucosal inflammation. STIs also serve as a marker for risky sexual behaviours. STIs increase infectiousness of people living with HIV by increasing the viral concentration in the genital tract, and by increasing the potential for HIV acquisition in people at risk for HIV. In addition, some STIs can increase blood HIV concentration and promote progression of disease. This review is designed to investigate the complex relationship between HIV and classical STIs. Discussion Treatment of STIs with appropriate antibiotics reduces HIV in blood, semen and female genital secretions. However, community‐based trials could not reliably reduce the spread of HIV by mass treatment of STIs. Introduction of antiretroviral agents for the treatment and prevention of HIV has led to renewed interest in the complex relationship between STIs and HIV. Antiretroviral treatment (ART) reduces the infectiousness of HIV and virtually eliminates the transmission of HIV in spite of concomitant or acquired STIs. However, while ART interrupts HIV transmission, it does not stop intermittent shedding of HIV in genital secretions. Such shedding of HIV is increased by STIs, although the viral copies are not likely replication competent or infectious. Pre‐exposure prophylaxis (PrEP) of HIV with the combination of tenofovir disoproxil fumarate and emtricitabine (TDF/FTC) prevents HIV acquisition in spite of concomitant STIs. Conclusions STIs remain pandemic, and the availability of ART may have led to an increase in STIs, as fear of HIV has diminished. Classical STIs present a huge worldwide health burden that cannot be separated from HIV, and they deserve far more attention than they currently receive.

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Section: Discussionmentioning

confidence: 99%

Sexually transmitted infections and HIV in the era of antiretroviral treatment and prevention: the biologic basis for epidemiologic synergy

2019

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“…These behavioural changes could result in condom use for some individuals, however, there are other interesting alternatives such as partner notification or BI for STIs. Recent studies on the prophylactic use of doxycycline for bacterial STIs have shown promising results post‐exposure and used daily , but remain to be confirmed in studies with longer follow‐up . Use of doxycycline may be particularly pertinent among PrEP users who experience recurrent STIs; a recent analysis has shown that among MSM PrEP users, 25% participants accounted for a little more than three‐quarters of all STIs .…”

Section: Discussionmentioning

confidence: 99%

Give PrEP a chance: moving on from the “risk compensation” concept

Castro

Delabre²,

Molina

2019

J Intern AIDS Soc

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Introduction While bio‐behavioural interventions (BIs) for sexually transmitted infections (STIs) and HIV prevention have shown their effectiveness (e.g. treatment for syphilis, HPV vaccination or pre‐exposure prophylaxis [PrEP]), they have also aroused major concerns regarding behavioural changes that could counteract their benefit. Risk compensation (RC) fears concerning BIs in the HIV/STIs prevention field are intimately linked to representations, judgements and social control on sexual behaviour. With an increasing number of PrEP studies describing a rise in STIs due to RC, this paper argues for a shift away from the focus on RC and proposes a more constructive approach to respond to the needs of people living with HIV and populations most at risk. Discussion The concept of RC, stemming from road safety and derived from economic theory, relies on rational theoretical models of human behaviour. Although widely applied in several contexts its use has been reasonably questioned. Major methodological issues regarding RC have been raised within HIV/AIDS literature. Although behavioural changes (e.g. condomless sex and number of sexual partners) are often erroneously assimilated with RC, there is no evidence that behavioural changes have undermined the effectiveness of previous and current BIs. Still, PrEP has not escaped RC concerns. Increases in condomless sex within the context of growing uptake of PrEP signals a continued need for integrated and innovative HIV and STI prevention strategies and a comprehensive sexual health approach. Routine HIV/STI testing, peer‐led counselling, and identification of sexual health needs within the PrEP model of care could become a gold standard in the sexual health field for all populations. Conclusions RC remains a frequent argument against the availability and provision of prevention methods for vulnerable populations. Individuals should be able to benefit from the full panel of BIs options available, to find and adapt methods according to their needs. Current, past and future PrEP users, with other stakeholders, may provide valuable insight into innovative solutions and programmes to control HIV and other STIs.

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“…POCTs will increase the uptake of STI screening in vulnerable populations that are at highest risk and will have an impact on detection and treatment. [123][124][125][126].…”

Section: Discussionmentioning

confidence: 99%

“…As already noted, HIV PrEP trials have found high incidence of classical STIs [96][97][98]104]. Bolan et al [124] and Molina et al [125] have reported the successful use of doxycycline prophylaxis to reduce the incidence of syphilis and chlamydia in high risk MSM. Doxycycline was not effective for prevention of gonorrhoea.…”

Section: Prep For Stismentioning

confidence: 99%

Untitled

2019

J Intern AIDS Soc

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Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial

Abstract: France Recherche Nord & Sud Sida-HIV Hépatites (ANRS) and Bill & Melinda Gates Foundation.

Cited by 253 publications

References 27 publications

Sexually transmitted infections and HIV in the era of antiretroviral treatment and prevention: the biologic basis for epidemiologic synergy

Sexually transmitted infections and HIV in the era of antiretroviral treatment and prevention: the biologic basis for epidemiologic synergy

Give PrEP a chance: moving on from the “risk compensation” concept

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