Post-harvest freezing injury reduces exterior quality of medicinal material and promotes transformation from glycosides to aglycones in Scutellaria baicalensis

Zhang, Meng; Cao, Bo; Che, Lingyu; Liu, Lianjin; Su, Yiyang; Zhou, Xiaofan; Lu, Yuanyuan; Li, Guishuang; Bai, Chengke

doi:10.1016/j.indcrop.2023.116915

Cited by 4 publications

(1 citation statement)

References 45 publications

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“…It is worth mentioning that most of the approved drugs are organic-based agents [ 9 ]. Scutellaria baicalensis Georgi (SBG) is a plant of the family Lamiaceae with many useful pharmaceutical features such as anticancer, antimicrobial, antioxidant, and anti-inflammatory properties [ 10 , 11 ]. Its dried root, Huang Qin, is one of the primary medicinal sources in traditional Chinese medicine [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms Involved in Therapeutic Effects of Scutellaria baicalensis Georgi in Oral Squamous Cell Carcinoma Based on Systems Biology and Structural Bioinformatics Approaches

Bayat,

Mazaheri,

Farhadifard

et al. 2024

BioMed Research International

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Objective. Oral squamous cell carcinoma (OSCC) is the most frequent oral cancer, constituting more than 90% of all oral carcinomas. The 5-year survival rate of OSCC patients is not satisfactory, and therefore, there is an urgent need for new practical therapeutic approaches besides the current therapies to overcome OSCC. Scutellaria baicalensis Georgi (SBG) is a plant of the family Lamiaceae with several pharmaceutical properties such as antioxidant, anti-inflammatory, and anticancer effects. Previous studies have demonstrated the curative effects of SBG in OSCC. Methods. A systems biology approach was conducted to identify differentially expressed miRNAs (DEMs) in OSCC patients with a dismal prognosis compared to OSCC patients with a favorable prognosis. A protein interaction map (PIM) was built based on DEMs targets, and the hub genes within the PIM were indicated. Subsequently, the prognostic role of the hubs was studied using Kaplan-Meier curves. Next, the binding affinity of SBG’s main components, including baicalein, wogonin, oroxylin-A, salvigenin, and norwogonin, to the prognostic markers in OSCC was evaluated using molecular docking analysis. Results. Survival analysis showed that overexpression of CAV1, SERPINE1, ACTB, SMAD3, HMGA2, MYC, EIF2S1, HSPA4, HSPA5, and IL6 was significantly related to a poor prognosis in OSCC. Besides, molecular docking analysis demonstrated the ΔGbinding and inhibition constant values between SBG’s main components and SERPINE1, ACTB, HMGA2, EIF2S1, HSPA4, and HSPA5 were as <-8.00 kcal/mol and nanomolar concentration, respectively. The most salient binding affinity was observed between wogonin and SERPINE1 with a criterion of ΔGbinding<−10.02 kcal/mol. Conclusion. The present results unraveled potential mechanisms involved in therapeutic effects of SBG in OSCC based on systems biology and structural bioinformatics analyses.

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Section: Introductionmentioning

confidence: 99%

Mechanisms Involved in Therapeutic Effects of Scutellaria baicalensis Georgi in Oral Squamous Cell Carcinoma Based on Systems Biology and Structural Bioinformatics Approaches

Bayat,

Mazaheri,

Farhadifard

et al. 2024

BioMed Research International

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Optimization of extraction, separation and purification of baicalin in Scutellaria baicalensis using response surface methodology

Liu,

Zhang,

Cao

et al. 2024

Industrial Crops and Products

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Research progress of traditional Chinese medicine compound “Chaihu Shugan Powder” in the treatment of premenstrual syndrome

Chu,

Gao,

Wang

et al. 2024

Medicine

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Background: This paper aims to conduct a comprehensive and insightful review and analysis of the potential targets and corresponding pathways of Chaihu Shugan Powder (CSP) for the treatment of premenstrual syndrome (PMS) using a network pharmacology approach. The review will encompass traditional applications, active ingredients of Chinese medicines, clinical applications, pharmacological mechanisms, and active ingredients. Methods: The active ingredients, pharmacological mechanisms, and clinical applications of the herbal ingredients in the CSP formulation were summarized by searching the literature, and the main signaling pathways of the CSP formulation for the treatment of PMS were identified by network pharmacological studies. Results: CSP is a representative traditional Chinese medicine formula known for its liver detoxification properties and its effectiveness in alleviating depression. It is also recognized as one of the most widely used formulas for treating PMS. In this study, we systematically summarized the active ingredients and pharmacological mechanisms of the 7 traditional Chinese medicine components present in CSP. Through network pharmacology analysis, we identified 75 common targets of CSP relevant to the treatment of PMS. These targets were predominantly concentrated within 17 specific signaling pathways, elucidating the potential molecular mechanisms underlying CSP’s therapeutic effects on PMS. Conclusion: In this paper, we have reviewed CSP and PMS, investigated the potential targets and corresponding pathways of CSP for the treatment of PMS, and systematically summarized the active ingredients and pharmacological mechanisms of 7 herbal components. In addition, 17 pathways of CSP for PMS were identified for future research and clinical application. However, the specific mechanism of action of CSP for the treatment of PMS is only based on literature and online pharmacological studies, and no basic or clinical experiments have been conducted. In addition, CSP has many components with complex and varied interactions, and the effects of certain compounds may be overlooked. Based on the present findings, it is beneficial to further explore the mechanism of action of the new effector compounds and the prospect of their application in basic research and clinical trials. In conclusion, the revelation of new effector compounds and mechanisms of action is conducive to the further clinical application of CSP, the discovery of new targets for PMS, and the modernization of Chinese medicine.

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Post-harvest freezing injury reduces exterior quality of medicinal material and promotes transformation from glycosides to aglycones in Scutellaria baicalensis

Cited by 4 publications

References 45 publications

Mechanisms Involved in Therapeutic Effects of Scutellaria baicalensis Georgi in Oral Squamous Cell Carcinoma Based on Systems Biology and Structural Bioinformatics Approaches

Mechanisms Involved in Therapeutic Effects of Scutellaria baicalensis Georgi in Oral Squamous Cell Carcinoma Based on Systems Biology and Structural Bioinformatics Approaches

Optimization of extraction, separation and purification of baicalin in Scutellaria baicalensis using response surface methodology

Research progress of traditional Chinese medicine compound “Chaihu Shugan Powder” in the treatment of premenstrual syndrome

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