Post-hematopoietic stem cell transplantation in patients with hematologic disorders: Chinese herbal medicine for an unmet need

Application of Herbal Medicine as Proliferation and Differentiation Effectors of Human Stem Cells

“…Proliferation, differentiation and in vitro expansion of healthy hHSCs are important as many haematological malignancies disrupt the healthy hHSC populations. A review that summarizes a wide range of research publications on the use of Chinese herbal medicine (CHM) to promote recovery after HSC transplantation had elaborated the positive results of herbal extracts from plants such as Sheng Di Huang (Rehmannia glutinosa), Bai Zhu (Atractylodes macrocephala), Ren Shen (Panax), Dang Shen (Codonopsis pilosula), Mai Men Dong (Ophiopogon japonicus), Dang Gui (Angelica sinensis), Tai Zi Shen (Pseudostellaria heterophylla), Huang Qi (Astragalus membranaceus) and Ejiao (Equus asinus) [35]. A study on autologous and allogenic HSC transplanted in patients with chronic granulocytic leukaemia, acute non-lymphocytic leukaemia and lymphoma were treated with CHM concluded that treating with CHM reduces complications of transplantations and promotes recovery of haematopoietic functions [36].…”

“…A study on autologous and allogenic HSC transplanted in patients with chronic granulocytic leukaemia, acute non-lymphocytic leukaemia and lymphoma were treated with CHM concluded that treating with CHM reduces complications of transplantations and promotes recovery of haematopoietic functions [36]. More research on various other HSC transplantations against haematological malignancies such as severe aplastic anaemia patients [37], patients with myelodysplastic syndrome [38] and acute paediatric leukaemia [39] were cited herein [35], which had given positive results on patient survival rates, reduction of complications and increasing functional properties of haematopoietic cells. However, most of these studies were based on a low number of samples; hence, the need to perform such studies in large populations arises in order to validate and standardize the CHM procedures.…”

“…China seems to be much ahead in this hybrid system of research using Chinese traditional herbs/isolated compounds and cutting-edge screening technologies. Although there is a plethora of internationally published research by research groups from China, many clinical trials and small population studies seem to be concealed from the rest of the world as these reports are published in local journals in their native language [35]. China is not alone in this exercise.…”

Etnobotánica urbana: el conocimiento botánico local sobre las plantas alimenticias y medicinales, y sus usos, en la conurbación Buenos Aires-La Plata

“…E: antioxidante (Thitilertedechea et al Mei et al2014), antibacteriano (Yuvakkumar et al 2014). E: antioxidante, antimicrobiano, inmunomodulador, anticáncer, antitusivo, antiinflamatorio, protector cardiovascular (Hou & Jin 2012;, antinefrítico, antidiabético, hipoglucémico, hipolipidémico (Jia et al 2003;Wang et al 2015), hepatoprotector (Lu et al 2014), anti-obesidad , prebiótico (Shi et al 2015), hematopoyético (Fleischer et al 2016), antiosteoporosis , antitrombótico (Kou et al 2006), neuroprotector , ansiolítico (Lin & Zhao 2015), sedante, anti-insomnio , anti-fatiga (Chen et al . 2010 E: antioxidante, antiinflamatorio, inmunomodulador, antiviral, antibacteriano, hipoglucémico, protector cardiovascular, antiarterioesclerótico, anti-obesidad hipolipidémico (He & Dai 2011;Zhang et al 2015;Parker et al 2016), anticáncer (Lam et al 2015), antitrombótico (Ye et al2016), hematopoyético , antidermatósico , neuroprotector (Fu et al 2015; anticonceptivo (Zhang et al 2016), antidepresivo (Farahani et al 2015), anti-amenorrea (Arentz et al 2015), relajante uterino (Hehir & Morrison 2016), potenciador sexual: disfunción eréctil, hiperplasia prostática, androgénico (Washida et al 2009;Hetchman 2013).…”

“…E: antioxidante (Ma et al 2012;Huang et al 2013), desintoxicante (Lee et al 2012). M: febrífugo, depurativo, antihemorrágico: epistaxis, hematemesis, hematuria, antianémico, emenagogo, antiamenorrea, anti-metrorragia, anti-espermatorrea, tónico hepático, anti-estreñimiento, antinefrítico, antidiabético, analgésico (dolor de pecho y piernas, espalda, estómago), E: protector cardiovascular, hemostático, antianémico, hematopoyético, diurético, antiinflamatorio (Chang et al 2001;Lee et al 2014;Fleischer et al 2016), antidiabético, hipoglucemiante (Jia et al 2003;Zhang et al 2004), nefroprotector (Hsu et al 2014), hipocolesterolémico, faringo-laringitis, anti-tinnitus, afrodisíaco: impotencia.…”