Post Heparin Plasma Lipoprotein Lipase Activity in Thyroid Disease

Kirkeby, Knut; Bjerkedal, Inger

doi:10.1530/acta.0.0590555

Cited by 25 publications

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“…Other than a slight increase in perfusate flow rate (P < 0.01) in livers from animals treated with 10 ,ug TJ100 g body wt per d for 7 d, perfusion parameters were similar to the controls, perfusate flow rate was 3.0±0.2 ml/min per g liver in livers from the control rats and 3.9+0.1 ml/min per g liver for T3 treated aniiimals. All perfusion parameters were similar for animals treated with either T3 or PTU for only 3 …”

Section: Resultsmentioning

confidence: 84%

“…INTRODUCTION Alterations in thyroid status appear to be associated with changes in serum triglyceride concentrations. In human hyperthyroidism, decreased (1), normal (2)(3)(4), and increased (5) serum concentrations of triglyceride have been observed. Concentrations ofserum triglyceride, although usually elevated in human hypothyroidism (1)(2)(3)(5)(6)(7)(8)(9), have also been reported to be normal (10,11).…”

mentioning

confidence: 99%

“…In human hyperthyroidism, decreased (1), normal (2)(3)(4), and increased (5) serum concentrations of triglyceride have been observed. Concentrations ofserum triglyceride, although usually elevated in human hypothyroidism (1)(2)(3)(5)(6)(7)(8)(9), have also been reported to be normal (10,11). When hypothyroid subjects were treated with thyroid hormone preparations, the serum triglyceride concentration returned toward normal (2,7,9), although exceptions were reported (8).…”

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confidence: 99%

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Influence of Thyroid Status on Lipid Metabolism in the Perfused Rat Liver

Keyes¹,

Heimberg²

1979

J. Clin. Invest.

109

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A B S T R A C T Thyroid disease is often accompanied by changes in the concentrations of serum lipids and lipoproteins. To evaluate the hepatic contribution to the serum abnormalities in thyroid disease, we examined fatty acid metabolism in perfused livers from pair-fed rats made hypothyroid with propylthiouracil (PTU) or made hyperthyroid by treatment with triiodothyronine (T3). The animals treated with T3 became hyperphagic, depending on dose of drug and duration of hyperthyroidism. It was necessary, therefore, for appropriate controls, that food intake of T3-treated rats be restricted to quantities consumed by euthyroid rats. Animals treated with PTU for 2 wk became hypophagic, and therefore, food consumption of controls was restricted to that eaten by rats receiving PTU. Dependent on dose of T3 and duration of treatment, the output of triglyceride and glucose was diminished, whereas output of ketone bodies was increased by livers from hyperthyroid animals. In contrast, livers from PTUtreated animals secreted increased amounts of triglyceride and glucose, whereas ketogenesis was diminished. The best models for study proved to be animals treated with either 10 gg T3/100 g body wt per d or 1 mg PTU/100 g body wt per d for 7 d. Under these conditions, all animals consumed the same quantity of food as did the euthyroid rats, but continued to display the metabolic alterations outlined above. The effects of PTU on hepatic metabolism were readily reversible by simultaneous administration ofT3. It is clear from these data that the thyroid status of the rat regulates hepatic triglyceride formation and secretion, and ketogenesis.

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Section: Resultsmentioning

confidence: 84%

mentioning

confidence: 99%

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confidence: 99%

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Influence of Thyroid Status on Lipid Metabolism in the Perfused Rat Liver

Keyes¹,

Heimberg²

1979

J. Clin. Invest.

109

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“…This is in sharp contrast to the situation in cholesterol metabolism, which is well explored in both hyper-and hypothyroidism and is generally believed to undergo typical and consistent changes in both conditions. The plasma triglyceride concentration may be completely normal in hypothyroidism (1,2), but usually it is moderately elevated (2)(3)(4)(5) and occasional cases of gross hyperlipemia have been reported in myxedema (1,2,6). The increase has been attributed to a low lipoprotein lipase (LPL) activity, since it has been shown that the postheparin plasma lipolytic activity (PHLA) is inversely corre-'Abbreviations used in this paper: LDL and VLDL, low density and very low density lipoprotein, respectively; LPL, lipoprotein lipase; PBI, protein-bound iodine; PHLA, lipolytic activity of postheparin plasma; RBW, relative body weight; T3, triiodothyronine uptake by resin; TG, triglyceride.…”

Section: Introductionmentioning

confidence: 99%

Plasma triglyceride metabolism in thyroid disease

Nikkilä¹,

Kekki²

1972

J. Clin. Invest.

216

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A B S T R A C T Plasma endogenous triglyceride transport kinetics were determined in 16 hyperthyroid and in 12 hypothyroid patients and the results compared with those of euthyroid control subjects. In addition, the removal of exogenous particulate fat (Intralipid; Vitrum, Sweden) from the circulation and the postheparin plasma lipolytic activity (PHLA) were studied in these patients for further characterization of the alterations of plasma triglyceride metabolism in thyroid disease.In thyrotoxicosis the average plasma triglyceride level was slightly but significantly increased above that of control subjects. This change was associated with augmented production of triglycerides whereas the mean fractional removal rate was not different from normal. There was a significant linear correlation between the concentration and turnover rate of plasma triglycerides in both hyperthyroid and euthyroid subjects but the concentration/turnover rate ratio was less in the former group suggesting that the efficiency of removal of triglycerides from the circulation was improved in thyroid hyperfunction. The elimination of intravenously administered particulate fat occurred more rapidly in untreated hyperthyroid patients than in euthyroid control subjects. The mean PHLA was also above normal in thyrotoxicosis. Upon adequate treatment of the hyperthyroid state the fasting plasma triglyceride concentration was further increased.Hypothyroid patients showed another pattern of alteration of triglyceride kinetics. The synthesis of plasma triglycerides was normal but the fractional removal of both endogenous and exogenous triglycerides was markedly reduced and this change seems to account for the hypertriglyceridemia associated with thyroid hypofunction. The plasma PHLA was also clearly decreased in the hypothyroid state.Plasma FFA and glycerol levels were increased in hyperthyroidism and plasma FFA was slightly deReceived for publication 17 January 1972 and in revised form 3 April 1972. creased in hypothyroid patients, but these variables were not significantly correlated with any parameter of triglyceride metabolism.Endogenous triglyceride turnover rate was significantly correlated with serum protein-bound iodine (PBI) and T3 uptake in thyrotoxicosis but not in hypothyroidism. Removal of exogenous fat was not related to postheparin plasma lipolytic activity but the fractional endogenous triglyceride transport showed a highly significant relationship to this lipase activity in a mixed group of hyper-and hypothyroid patients.The results suggest that thyroid hormones control both production and removal of plasma triglycerides.

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“…Unter dem Einfluß von Schilddrüsenhormonen kommt es zu einer Verände rung der Plasma-Spiegel von Cholesterin und Neutralfetten (JACOBSEN, 1973;KIRKEBY, 1969;NIKKILA LL KEKKI, 1972;WIELAND U. SEIDEL, 1972 Bei der Schilddrüsen-Überfunktion werden übereinstimmend erhöhte Nüch ternwerte der freien Fettsäuren im Plasma angegeben (AVOGARO etal, 1965;CLAYTON U. BIERMAN, 1959;DIETERLE etal., 1969;DOAR etal, 1969;EATON et al, 1965;FELT, 1967;HALES U. HYAMS, 1964;HARLAN etal., 1963;JAHNKE et ai, 1965;LEVY et al, 1970;MARKS et al, 1960;RICH et al, 1959;SANDHOFER et al, 1966aSANDHOFER et al, , 1966bSANDHOFER et al, , 1967bVINIK et al. 1970;WOEBER et al, 1966).…”

Section: C) Lipolyse Und Fettstoffwechselunclassified

Die Stoffwechselwirkungen der Schilddrüsenhormone

Dieterle¹,

Scriba²

1975

Diabetes Mellitus · A

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Post Heparin Plasma Lipoprotein Lipase Activity in Thyroid Disease

Cited by 25 publications

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Influence of Thyroid Status on Lipid Metabolism in the Perfused Rat Liver

Influence of Thyroid Status on Lipid Metabolism in the Perfused Rat Liver

Plasma triglyceride metabolism in thyroid disease

Die Stoffwechselwirkungen der Schilddrüsenhormone

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