Post-Histoplasmosis Fibrosing Mediastinitis

Pulmonary paracoccidioidomycosis‐induced pulmonary hypertension

“…δ P < .05 demonstrate the vascular adventitial layer remodeling and pulmonary hypertension induced in post-PCM infection and suggest that in postcured PPCM patients there is a late self-sustained myofibroblastic activation in the small vessels adventitia layer with a subsequent increase in perivascular collagen deposition and development of pulmonary hypertension, similar to histoplasmosis-induced fibrosing mediastinitis and Idiopathic pulmonary fibrosis. 8,9 Fifteen lung biopsies from patients diagnosed with PCM between 2007 and 2017 were reviewed and showed similar findings to the animal model. Like in experimental data, significant expansion of the vascular adventitial layer by collagen fibers deposition was identified (Figure 2), which was more pronounced in small sized vessels (<50 μm) rather than medium-and large-sized vessels, regardless the distance between the vessels and the granulomas.…”

Post-tuberculosis fibrosing mediastinitis: A report of 3 cases

“…This causes the pulmonary infection to spread to the mediastinal lymph nodes, leading to their calcification, followed by the release of fungal antigens into the mediastinal space, triggering a hypersensitivity reaction and ultimately fibrosis. The diffuse idiopathic form of fibrous mediastinitis (18%) is considered to fall within the IgG4-RD spectrum, including conditions such as retroperitoneal fibrosis or Riedel's thyroiditis [ [3] , [4] ].…”