2024
DOI: 10.1186/s40246-024-00634-4
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Post-implantation analysis of genomic variations in the progeny from developing fetus to birth

Yingming Zheng,
Chuanping Lin,
Wen-Jing Wang
et al.

Abstract: The analysis of genomic variations in offspring after implantation has been infrequently studied. In this study, we aim to investigate the extent of de novo mutations in humans from developing fetus to birth. Using high-depth whole-genome sequencing, 443 parent-offspring trios were studied to compare the results of de novo mutations (DNMs) between different groups. The focus was on fetuses and newborns, with DNA samples obtained from the families’ blood and the aspirated embryonic tissues subjected to deep seq… Show more

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