Post-infectious cough of different syndromes treated by traditional Chinese medicines: A review

Jiang, Wanru; Qi, Jiaxin; Li, Xu; Chen, Gang; Zhou, Di; Xiao, Wei; Li, Ning

doi:10.1016/j.chmed.2022.09.002

Cited by 11 publications

(13 citation statements)

References 18 publications

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“…32 Studies have shown that the c-Fos protein content in lung tissue of PIC mice induced by respiratory syncytial virus is significantly increased. 1,8 At the same time, there is a large amount of inflammatory cell infiltration around the airway and blood vessels of PIC mice, and the number of eosinophils in BALF is significantly increased. The expression of IL-4, IL-5, and IL-13 in serum is significantly increased.…”

Section: Discussionmentioning

confidence: 99%

“…The shedding of airway epithelial cells exposes a large number of nerve fibers, causing the airway to be highly reactive 32 . Studies have shown that the c‐Fos protein content in lung tissue of PIC mice induced by respiratory syncytial virus is significantly increased 1,8 . At the same time, there is a large amount of inflammatory cell infiltration around the airway and blood vessels of PIC mice, and the number of eosinophils in BALF is significantly increased.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that children with PIC often manifest with both respiratory symptoms, such as cough and phlegm, as well as digestive symptoms, such as dry stool. [5][6][7][8] Xiebai powder, a classic TCM prescription originating from the Northern Song Dynasty, consists of four herbs: japonica rice, Cortex Lycii, Cortex Mori, and licorice root. It has demonstrated effective alleviation of asthma and cough symptoms.…”

Section: Introductionmentioning

confidence: 99%

“…Traditional Chinese Medicine (TCM) suggests a connection between the lungs and large intestine through meridians and collaterals, known as the “exterior‐interior correlation.” Studies have shown that children with PIC often manifest with both respiratory symptoms, such as cough and phlegm, as well as digestive symptoms, such as dry stool 5‐8 . Xiebai powder, a classic TCM prescription originating from the Northern Song Dynasty, consists of four herbs: japonica rice, Cortex Lycii, Cortex Mori, and licorice root.…”

Section: Introductionmentioning

confidence: 99%

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Xiebai Zengye decoction improves respiratory function and attenuates inflammation in juvenile rats with postinfection cough via regulating ERK signaling pathway

Luo,

Deng,

Ding

et al. 2023

Cell Biochemistry & Function

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This study aimed to determine the effects of Xiebai Zengye decoction (XBZY) on airway inflammation and respiratory function in rats with postinfectious cough (PIC), and its regulatory effects on the extracellular signal‐regulated kinase (ERK) signaling pathway. Compared with the normal group, the rats from the PIC group had significantly shortened expiratory time (TE) and enhanced pause (EEP), increased resistance (RT), and enhanced pause (Penh), along with increased levels of serum interleukin‐4 (IL‐4) and IL‐6, and decreased levels of IL‐10. The lung and colon tissues of rats from the PIC group showed histopathological changes, including inflammatory cell infiltration, damaged mucosal epithelium, and crypt structure, with significantly increased ERK mRNA and protein expression levels. Treatment with XBZY and montelukast sodium (MAS) improved the respiratory function and serum cytokine levels, reduced tissue inflammation, and decreased ERK mRNA and protein expression levels in the lung and colon tissues. In the lung tissues, XBZY treatment significantly decreased the expression of phosphorylated‐ERK (p‐ERK) protein, as well as p‐MEK1/2, p‐ERK1/2, and p‐c‐Fos proteins, while in the colon tissues, XBZY significantly decreased the expression of p‐ERK1/2 and p‐c‐Fos proteins. However, MAS treatment only showed significant improvement in the lung tissue inflammation score, and the expression level of p‐ERK protein in the lung tissue was decreased. In conclusion, the present study suggests that XBZY has a potential therapeutic effect on PIC by improving respiratory function and attenuating inflammation, and this effect may be associated with the inhibition of the ERK signaling pathway. These findings could provide a new direction for the development of treatments for PIC. However, further research is needed to elucidate the underlying molecular mechanisms of XBZY and to confirm its safety and efficacy in clinical trials.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Xiebai Zengye decoction improves respiratory function and attenuates inflammation in juvenile rats with postinfection cough via regulating ERK signaling pathway

Luo,

Deng,

Ding

et al. 2023

Cell Biochemistry & Function

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“…FAs were obtained by converting flavonol glycosides into aglycones through hydrolysis in vitro and purification. However, TCM or natural products have the characteristics of multi-targets, multi-pathways and multi-pharmacological activities (Jiang et al, 2022;Zhao et al, 2022). GBCCM may exhibit a variety of pharmacological effects and complex doseeffect relationship at different drug concentrations and composition ratios.…”

mentioning

confidence: 99%

Pharmacological activities and effective substances of the component-based Chinese medicine of Ginkgo biloba leaves based on serum pharmacochemistry, metabonomics and network pharmacology

Liang

Yao²,

Yu³

et al. 2023

Front. Pharmacol.

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As a potential drug candidate for the treatment of hypertension and complications, it is speculated that the component-based Chinese medicine of Ginkgo biloba leaves (GBCCM) which mainly composed of flavonoid aglycones (FAs) and terpene lactones (TLs) may have different pharmacological effects at different doses or ratios. Taking the normal mice as the study object, metabonomics was conducted by giving different doses of GBCCM. Based on the components of GBCCM absorbed into the blood, the network pharmacological prediction was carried out. By integrating the results of metabonomics and network pharmacology, predict the possible pharmacological effects of GBCCM and conduct experimental verification. It was found that eight of the 19 compounds in GBCCM could be absorbed into the blood. GBCCM mainly affected the signal pathways of unsaturated fatty acid, pyruvate, bile acid, melanin and stem cells. It was speculated that GBCCM might have activities such as lowering blood pressure, regulating stem cell proliferation and melanogenesis. By establishing the models of mushroom tyrosinase, rat bone marrow mesenchymal stem cells (BMSCs) and spontaneously hypertensive rats (SHRs), we found that FAs and TLs showed synergistic effect in hypertension and tyrosinase models, and the optimal ratio was 3:2 (4.4 mg/kg) and 1:1 (0.4 mg/ml), respectively. As effective substances, FAs significantly promoted the proliferation of rat BMSCs on the third and fifth days at the concentration of 0.2 μg/ml (p < 0.05). GBCCM showed a variety of pharmacological effects at different doses and ratios, which provided an important reference for the druggability of GBCCM.

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Persistent cough in mild COVID‐19 successfully treated with chikujountanto, a traditional Kampo medicine: An observational cohort study

Chiba,

Shinohara

2024

Traditional & Kampo Medicine

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BackgroundCoronavirus disease 2019 (COVID‐19) causes a variety of cough symptoms in the acute and chronic phases. Chikujountanto (CUT) is a Kampo formula administered for persistent cough, and previous pharmacological studies have suggested the anti‐inflammatory properties of the crude drugs that make up CUT. This pilot study aimed to evaluate the efficacy of CUT for COVID‐19‐associated cough.MethodsA total of 56 COVID‐19 patients without hypoxia or lung disease were prospectively enrolled, and were treated with antivirals in our adult‐fever clinic from September 2022 to November 2023. Ten consecutive patients with cough refractory to antivirals, an inhaled corticosteroid plus a long‐acting β2 agonist (ICS/LABA), and bronchodilators were divided into two groups; CUT or bakumondoto (BAK) was used three times a day for at least one week in combination with ICS/LABA. The differences between the two groups were evaluated using Fisher's exact test for the 2 × 2 contingency table.ResultsThe median age was 50 years (interquartile range 36–54 years). Only one (20%) of the five participants remained persistently coughing seven days after treatment in the CUT group, compared to 100% in the BAK group (p < 0.05). The cough score decreased from 2.7 ± 0.8 at baseline to 0.5 ± 0.4 one week after CUT administration (p < 0.001).ConclusionThis pilot study suggests that CUT could be a treatment option for persistent cough in patients with mild COVID‐19. More randomized clinical trials with larger samples are required to better evaluate CUT as an anti‐inflammatory drug for SARS‐CoV‐2.

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Post-infectious cough of different syndromes treated by traditional Chinese medicines: A review

Cited by 11 publications

References 18 publications

Xiebai Zengye decoction improves respiratory function and attenuates inflammation in juvenile rats with postinfection cough via regulating ERK signaling pathway

Xiebai Zengye decoction improves respiratory function and attenuates inflammation in juvenile rats with postinfection cough via regulating ERK signaling pathway

Pharmacological activities and effective substances of the component-based Chinese medicine of Ginkgo biloba leaves based on serum pharmacochemistry, metabonomics and network pharmacology

Persistent cough in mild COVID‐19 successfully treated with chikujountanto, a traditional Kampo medicine: An observational cohort study

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