Post‐infectious irritable bowel syndrome in patients with <i>Shigella</i> infection

Ji, Sang-Won; Park, Hyojin; Lee, Dokyong; Song, Young Goo; Choi, Jeongyong; Lee, Sang In

doi:10.1111/j.1440-1746.2005.03574.x

Cited by 142 publications

(116 citation statements)

References 31 publications

(77 reference statements)

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“…Several studies have examined risk factors for PI-IBS [21,[28][29][30][31][32][33][34]. As found previously, risk of IBS was higher in females and younger age groups, although this was not significant.…”

Section: Discussionmentioning

confidence: 68%

“…Severity of GE (duration of diarrhoea, presence of blood in stools, abdominal cramps, weight loss), younger age and female gender have been associated with increased risk of PI-IBS [21,[28][29][30][31][32][33][34]. Anxiety, depression and major life events have also been identified as potential risk factors with some hypothesizing that these disorders prolong gut inflammation and heighten sensory perception [22,26,28,29,32,[35][36][37].…”

Section: Introductionmentioning

confidence: 99%

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Relative risk of irritable bowel syndrome following acute gastroenteritis and associated risk factors

et al. 2013

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SUMMARYA prospective cohort study using electronic medical records was undertaken to estimate the relative risk (RR) of irritable bowel syndrome (IBS) following acute gastroenteritis (GE) in primary-care patients in The Netherlands and explore risk factors. Patients aged 18-70 years who consulted for GE symptoms from 1998 to 2009, met inclusion/exclusion criteria and had at least 1 year of follow-up data were included. Patients with non-GE consultations, matched by age, gender, consulting practice and time of visit, served as the reference group. At 1 year, 1·2% of GE patients (N = 2428) had been diagnosed with IBS compared to 0·3% of the reference group (N = 2354). GE patients had increased risk of IBS [RR 4·85, 95% confidence interval (CI) 2·02-11·63]. For GE patients, concomitant cramps and history of psycho-social consultations were significantly associated with increased risk. GE patients had increased risk of IBS up to 5 years post-exposure (RR 5·40, 95% CI 2·60-11·24), suggesting there may be other contributing factors.

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Section: Discussionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Relative risk of irritable bowel syndrome following acute gastroenteritis and associated risk factors

et al. 2013

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“…The initial 1-year and 3-year surveys addressed epidemiologic data, past medical and surgical history, information regarding the presence of vomiting, fever, and duration of diarrhea during the acute illness, and information regarding current bowel symptoms according to the Rome II criteria. 17,24 The followup questionnaires at 5, 8, and 10 years after outbreak mainly addressed current bowel symptoms according to the Rome II criteria, as well as recent medical history of other gastrointestinal disorders, including incidence of additional enteric infection and/or abdominal surgery, which was exclusion criteria for subsequent analyses. 23 The diagnosis of IBS and other functional bowel disorders (FBDs) was made using the Rome II criteria, and other FBDs included functional abdominal bloating, functional constipation, functional diarrhea, and unspecified FBDs For the 10-year follow-up survey, investigators performed the survey questionnaire preferentially by face-to-face interview, and by telephone interview, if necessary.…”

Section: Methodsmentioning

confidence: 99%

“…12 Post-infectious IBS (PI-IBS) is defined as the acute onset of new IBS symptoms in an individual who has not previously met the criteria for IBS immediately following an acute illness characterized by 2 or more of the following: fever, vomiting, diarrhea, or positive bacterial stool culture. 12 Although there have been many reports regarding PI-IBS associated with pathogens such as Shigella spp., pathogenic Escherichia coli, Salmonella, Campylobacter jejuni, and Giardia duodenalis in the past 20 years, [13][14][15][16][17][18][19] most of these reports address the shortterm clinical course of PI-IBS, and only few examined the longterm course (≥ 5 years) of PI-IBS. [20][21][22][23] We previously reported on the clinical course of PI-IBS in a homogenous cohort comprised of patients recovered from shigellosis.…”

Section: Introductionmentioning

confidence: 99%

“…[20][21][22][23] We previously reported on the clinical course of PI-IBS in a homogenous cohort comprised of patients recovered from shigellosis. 17,23,24 In the current study, we report on the collective results of a 10-year, long-term follow-up of our small, well-followed, homogenous cohort of patients that developed PI-IBS after shigellosis.…”

Section: Introductionmentioning

confidence: 99%

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Long-term Clinical Course of Post-infectious Irritable Bowel Syndrome After Shigellosis: A 10-year Follow-up Study

Youn

Kim

Lim

et al. 2016

J Neurogastroenterol Motil

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Background/AimsA limited number of studies are available regarding the long-term natural history of post-infectious irritable bowel syndrome (PI-IBS). We aimed to investigate the long-term clinical course of PI-IBS. MethodsA prospective cohort study was conducted from a 2001 shigellosis outbreak in a Korean hospital with about 2000 employees. A cohort of 124 hospital employees who were infected by Shigella sonnei due to contaminated food in the cafeteria, and 105 sex-and age-matched, non-infected, controls were serially followed for their bowel symptoms by questionnaire surveys for 10 years. ResultsThe Shigella-infected cohort showed significantly higher odds ratio for irritable bowel syndrome (IBS) at 1-year (11.90; 95% CI, 1.49-95.58) and 3-year (3.93; 95% CI, 1.20-12.86) follow-up, compared to their controls. However, corresponding odds ratio for PI-IBS was not significantly increased at 5-year (1.88; 95% CI, 0.64-5.54) and 8-year (1.87; 95% CI, 0.62-5.19) follow-up. At 10-year followup survey, the prevalence of IBS was similar for the Shigella-infected cohort and their controls (23.3% versus 19.7%, P = 0.703). Risk factors which were independently associated with PI-IBS among the Shigella-infected cohort included younger age, previous history of functional bowel disorder, and longer duration of diarrhea at baseline. ConclusionsPatients who were infected by Shigella sonnei experienced significantly increased risk of IBS until 3 years after shigellosis, and modestly increased risk until 8 years, but showed similar risk of IBS with uninfected controls at 10 years post-infection. PI-IBS is quite a chronic disorder, and follows a long-term natural course.

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The possible role of bacteria, viruses, and parasites in initiation and exacerbation of irritable bowel syndrome

Shariati

Fallah

Pormohammad

et al. 2018

Journal Cellular Physiology

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Irritable bowel syndrome (IBS) is a prolonged and disabling functional gastrointestinal disorder with the incidence rate of 18% in the world. IBS could seriously affect lifetime of patients and cause high economic burden on the community. The pathophysiology of the IBS is hardly understood, whereas several possible mechanisms, such as visceral hypersensitivity, irregular gut motility, abnormal brain–gut relations, and the role of infectious agents, are implicated in initiation and development of this syndrome. Different studies demonstrated an alteration in B‐lymphocytes, mast cells (MC), T‐lymphocytes, and cytokine concentrations in intestinal mucosa or systemic circulation that are likely to contribute to the formation of the IBS. Therefore, IBS could be developed in those with genetic predisposition. Infections’ role in initiation and exacerbation of IBS has been investigated by quite several clinical studies; moreover, the possible role of some pathogens in development and exacerbation of this disease has been described. It appears that the main obligatory pathogens correspond with the IBS disease, Clostridium difficile, Escherichia coli, Mycobacterium avium subspecies paratuberculosis, Campylobacter concisus, Campylobacter jejuni, Chlamydia trachomatis, Helicobacter pylori, Pseudomonas aeruginosa, Salmonella spp, Shigella spp, and viruses, particularly noroviruses. A number of pathogenic parasites (Blastocystis, Dientamoeba fragilis, and Giardia lamblia) may also be involved in the progression and exacerbation of the disease. Based on the current knowledge, the current study concludes that the most common bacterial, viral, and parasitic pathogens may be involved in the development and progression of IBS.

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Post‐infectious irritable bowel syndrome in patients with Shigella infection

Abstract: Bacterial gastroenteritis is a risk factor of IBS and the duration of diarrhea as the index of severity of initial illness is an independent risk factor of PI-IBS. The clinical course of PI-IBS is variable over the 1 year of follow-up.

Cited by 142 publications

References 31 publications

Relative risk of irritable bowel syndrome following acute gastroenteritis and associated risk factors

Relative risk of irritable bowel syndrome following acute gastroenteritis and associated risk factors

Long-term Clinical Course of Post-infectious Irritable Bowel Syndrome After Shigellosis: A 10-year Follow-up Study

The possible role of bacteria, viruses, and parasites in initiation and exacerbation of irritable bowel syndrome

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