Post-lesion administration of 7-NI attenuated motor and non-motor deficits in 6-OHDA induced bilaterally lesioned female rat model of Parkinson’s disease

Botulinum Neurotoxin A Injected Ipsilaterally or Contralaterally into the Striatum in the Rat 6-OHDA Model of Unilateral Parkinson’s Disease Differently Affects Behavior

“…Unilateral 6-OHDA-injection decreased the overall spontaneous locomotor behavior as measured by total walking distance as already shown by others (Kirik et al, 2001; Tamás et al, 2005; Brown et al, 2011; Abedi et al, 2013; Capper-Loup et al, 2013; da Rocha et al, 2013; Sun et al, 2013; Machado-Filho et al, 2014; Chao et al, 2015; Kumari et al, 2015; Ximenes et al, 2015; Das et al, 2016; Sgroi et al, 2016). Reduced locomotion is tentatively interpreted as a result of depletion of striatal DA (Fearnley and Lees, 1991; Schwarting and Huston, 1996; Alam and Schmidt, 2002; Ferro et al, 2005; Carvalho et al, 2013), although there is no clear explanation why a unilateral DA depletion has such a massive effect (about 50% reduction) on total walking distance as a measure of whole body bradykinesia of the hemi-PD rats.…”

Updates on Versatile Role of Putative Gasotransmitter Nitric Oxide: Culprit in Neurodegenerative Disease Pathology

“…If the production of NO crosses a threshold, it could initiate pathological reactions . Such augmented level of NO may be due to activated glial cells as reviewed by us previously. − However, nNOS-inhibitor-mediated neuroprotection has also been reported, − suggesting the participation of neurons and indicating the close functional association of neuron and glial cells during disease pathology. Additionally, it has been reported that selective nNOS inhibitor, 7-nitroindazole, inhibits the disease relatedglial activation .…”

Influência do interferon-γ sobre o parkinsonismo, na discinesia induzida pelo tratamento com L-DOPA e na expressão de fatores neuroinflamatórios

“…Dessa vez corroborando com a literatura, encontramos aumento da concentração de IFN-γ no estriado lesionado. Da mesma maneira, foi encontrado níveis aumentados de IFN-γ no plasma (MOUNT et al, 2007), no estriado e SNc (MOGI et al, 2007) -FILHO et al, 2014;NEVES et al, 2015;XIMENES et al, 2015;LIANG et al, 2019), como também prejudicou a coordenação motora dos animais (KUMARI;KUMAR;LUTHRA, 2015;LIANG et al, 2019). Não há um consenso sobre o efeito do IFN-γ na locomoção e os estudos apresentaram resultados contraditórios.…”