“…Efforts for reducing community transmission of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2), the causative agent for Coronavirus disease 2019 (COVID-19), initially focused on dramatic measures including federally-endorsed and state-mandated “shut-downs.” These included closure of schools (primary, secondary, and higher education), businesses, churches, and events, as well as restrictions on travel and nearly all commercial and non-commercial activities outside the home. These restrictions were effective in slowing the emergence of the pandemic in the US [ 1 ], but inflicted great costs, economic and otherwise [ 2 , 3 ]. With the recognition that these measures could not be permanent, and as understanding of transmission increased, more targeted policy recommendations became common, including reduction of large gatherings, encouragement of social distancing, utilization of face coverings [ 4 ], and eventually vaccination.…”