Post-natal stress-induced endocrine and metabolic alterations in mice at adulthood involve different pro-opiomelanocortin-derived peptides

Enhanced brain performance in mice following postnatal stress

“…Thus, we demonstrated that some type-2 diabetes-like signs produced by stress are prevented by naloxone treatment in the nursing period to block endogenous m-d opioid system hyper-function; whereas these and all other diabetes-like signs are prevented through administration of an antisense (AS) oligodeoxynucleotide to block synthesis-release of POMC mRNA and therefore to block both opioid and ACTH-corticosteroid system hyper-function. Also feedback mechanism disruption and hormone enhancement induced by stress at the pituitary level, at weaning and thereafter, are then prevented, thus strongly confirming our hypothesis , Loizzo et al 2010a.…”

“…Therefore, we can hypothesize that hyperglycemia is an ACTHcorticosterone-bound sign in our diabetes model. Conversely, naloxone treatment is more effective than AS for the prevention of stress-induced overweight, therefore increase of body weight may appear as a prevalent opioid-dependent parameter (Part of data was taken from Loizzo et al (2010a)). …”

An overview of maternal separation effects on behavioural outcomes in mice: Evidence from a four-stage methodological systematic review

“…According to Nylander and Roman (2013), the consequence of the variability in protocols is that there is no single 'rodent maternal separation model' but several separation models with different effects. Although separation models are not safe from criticism (Molet et al, 2014), a large body of ELS evidence indicates that postnatal manipulations are important models for investigating the early-life impact on depressive and anxiety-like behaviours (Andersen, 2015;Millstein and Holmes, 2007;Romeo et al, 2003;Schmidt et al, 2011;Vetulani, 2013), drug-seeking behaviours (Cruz et al, 2008;Garcia-Gutierrez et al, 2015;Huot et al, 2001;Kawakami et al, 2007;Nylander and Roman, 2013) and neuroendocrine stressinduced responses among rodents (Anisman et al, 1998;Kawakami et al, 2013;Loizzo et al, 2010;Parfitt et al, 2004;Parfitt et al, 2007). The evidence has provided reliable implications for face, construct and predictive validity for MS rodent studies (Plotsky et al, 2005;Schmidt et al, 2011).…”

Antisense versus proopiomelanocortin mRNA reduces vascular risk in a murine model of type-2 diabetes following stress exposure in early post-natal life

“…We previously described a murine model for type-2 diabetes with face construct and predictive validity, where alterations similar to those occurring in human type-2 diabetes were induced by postnatal exposure to stress [11,13,15,16]. Other investigators have confirmed the effectiveness of this model [24,34].…”

“…Targeting the opioid receptor with an antagonist, or using an antisense phosphorothioate oligodeoxinucleotide against http://dx.doi.org/10.1016/j.peptides.2014.12.006 0196-9781/© 2015 Elsevier Inc. All rights reserved. pro-opiomelanocortin mRNA (AS-POMC) capable to significantly decrease both ACTH and ␤-endorphin peptides, selectively prevents the development of these alterations [5,11,16,19].…”