We prospectively evaluated the effects of pneumoperitoneum and reverse Trendelenburg position on cardiopulmonary function in 20 ASA physical status II±III morbidly obese patients (body mass index >35 kg m À2 ) undergoing laparoscopic gastric banding. After general anaesthesia was induced, patients' lungs were ventilated using intermittent positive pressure ventilation (at measurement times, the following parameters were used: tidal volume 12 mL kg À1 ideal body weight, respiratory rate of 12 bpm, an inspiratory to expiratory time ratio of 1 : 2). Haemodynamic variables, blood gas parameters, and lung/chest compliance were recorded: in the supine position, after induction of general anaesthesia (T 0 , baseline) and induction of pneumoperitoneum (T 1 ); after placing the patient in a 25 reverse Trendelenburg position (T 2 ); during the surgical time (T 3 ); before de¯ating the abdomen (T 4 ); after pneumoperitoneum resolution (T 5 ), and before the end of anaesthesia, with the patient supine (T 6 ). The P a O 2 , P a O 2 /F i O 2 ratio, and lung/chest compliance decreased during the study. After the pneumoperitoneum had been resolved, lung/chest compliance but not oxygenation parameters returned to baseline values. The arterial to end-tidal CO 2 tension difference progressively increased from 0.38 0.3 kPa (2.85 2.25 mmHg) (T 0 ) to 0.63 0.3 kPa (4.73 2.25 mmHg) (T 6 ). In morbidly obese patients, undergoing laparoscopic gastric banding, a CO 2 pneumoperitoneum markedly affected gas exchange and lung/chest compliance, while positioning the patient in a 25 reverse Trendelenburg position had no bene®cial effects.