Post-operative effects of tramadol administered at wound closure

Witte, J. De; Rietman, G. W.; Vandenbroucke, G.; Deloof, T.

doi:10.1046/j.1365-2346.1998.00271.x

Cited by 4 publications

(9 citation statements)

References 3 publications

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“…Tramadol in doses of 1, 2 and 3 mg.kg −1 has been shown to be useful for prevention of postanaesthetic shivering [11, 12]. Mathews et al.…”

Section: Discussionmentioning

confidence: 99%

“…De Witte and coworkers showed that administration of tramadol in a high dose i.e. 3 mg.kg −1 at the time of wound closure prevented postanaesthetic shivering in all the study patients [12]. However, an extensive search of the literature revealed no studies comparing tramadol with the commonly used drug pethidine to prevent postanaesthetic shivering in patients recovering from general anaesthesia.…”

Section: Discussionmentioning

confidence: 99%

“…It is not associated with clinically significant side‐effects such as respiratory depression or sedation [7]. During the last few years, intravenous tramadol has been used to treat or prevent shivering in the postoperative period [8–12] and has shown good prophylactic antishivering effect in doses of 1, 2 and 3 mg.kg −1 [11, 12]. Pethidine is one of the most effective drugs for control of postanaesthetic shivering and is widely used for this purpose [2, 13].…”

mentioning

confidence: 99%

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Tramadol for prevention of postanaesthetic shivering: a randomised double‐blind comparison with pethidine

Mohta

Kumari²,

Tyagi

et al. 2009

Anaesthesia

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SummaryThe present study was conducted with the aims of comparing intravenous tramadol 1, 2 and 3 mg.kg )1 with pethidine 0.5 mg.kg )1 for prophylaxis of postanaesthetic shivering and to find a dose of tramadol that could provide the dual advantage of antishivering and analgesic effect in the postoperative period. The study included 165 patients, randomly allocated to five groups of 33 each. Tramadol in doses of 1, 2 and 3 mg.kg, pethidine 0.5 mg.kg )1 or normal saline were administered at the time of wound closure. All three doses of tramadol were effective and comparable to pethidine in preventing postanaesthetic shivering. Tramadol 2 mg.kg )1 had the best combination of antishivering and analgesic efficacy without excessive sedation and thus appeared to be a good choice to be administered at the time of wound closure to provide antishivering effect and analgesia without significant side effects in the postoperative period.

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“…Tramadol in doses of 1, 2 and 3 mg.kg −1 has been shown to be useful for prevention of postanaesthetic shivering [11, 12]. Mathews et al.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Tramadol for prevention of postanaesthetic shivering: a randomised double‐blind comparison with pethidine

Mohta

Kumari²,

Tyagi

et al. 2009

Anaesthesia

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“…Tramadol 3 mg.kg −1 was used by DeWitte et al . at wound closure and postoperative effects were analysed [6]. It was observed that shivering was totally abolished.…”

Section: Discussionmentioning

confidence: 99%

“…Tramadol has been used in the treatment of postanaesthetic shivering by De Witte [5], who has also studied the postoperative effects of tramadol with the highest loading dose, 3 mg.kg −1 , at wound closure [6]. Tramadol, a synthetic opioid of the aminocyclohexanol group, is a unique analgesic that acts at multiple sites, with low risk of respiratory depression, tolerance and dependence.…”

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confidence: 99%

Postanaesthetic shivering ‐ a new look at tramadol

Mathews¹,

Mulla

Varghese

et al. 2002

Anaesthesia

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We studied whether tramadol administered at the time of wound closure can prevent postanaesthetic shivering. One hundred and fifty patients scheduled for general anaesthesia and surgery were randomly allocated and tramadol was administered intravenously at a dose of 2 mg.kg(-1) in the high-dose group, 1 mg.kg- in the low-dose group and 0.9% saline in the control group. In the high-dose group, 2% of patients had postanaesthetic shivering, compared to 4% in the low-dose group and 48% in the control group (p < 0.001 vs. tramadol groups). There was no delay in tracheal extubation after reversal of neuromuscular blockade. The incidence of adverse side-effects such as sedation and vomiting did not differ statistically and were clinically not significant. This study strongly supports the use of tramadol at wound closure for prevention of postanaesthetic shivering.

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Tramadol—Present and Future

Shipton

2000

Anaesth Intensive Care

182

134

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The atypical opioid, tramadol, has recently been introduced into Australia and New Zealand. Tramadol's efficacy in a wide range of acute and chronic pain states, its multi-formulation availability, and its low serious side-effect potential at high doses and in prolonged therapy, combine to bestow on it a user-friendly profile, for short-and long-term use in hospitals and communities. This paper reviews the following: its formulation and routes of administration; its unique enantiomeric biochemistry and metabolism; its triple mechanisms of action; its pharmacokinetics and pharmacodynamics; its analgesic efficacy compared with other opioids; the indications for its clinical use in a variety of acute and chronic (including cancer) painful states; its specific use in the elderly, in paediatric and in obstetric patients; its adverse event (including drug interaction) and safety profile; its advantages in terms of its relative lack of respiratory depression, major organ toxicity and histamine release, and dependence and abuse potential. The review looks at new uses for this drug and what can be expected in this area in the future.

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Post-operative effects of tramadol administered at wound closure

Cited by 4 publications

References 3 publications

Tramadol for prevention of postanaesthetic shivering: a randomised double‐blind comparison with pethidine

Tramadol for prevention of postanaesthetic shivering: a randomised double‐blind comparison with pethidine

Postanaesthetic shivering ‐ a new look at tramadol

Tramadol—Present and Future

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