Post-operative neutrophil–lymphocyte ratio predicts complications following colorectal surgery

Cook, Emily J.; Walsh, Stewart R.; Farooq, Naheed; Alberts, Justin; Justin, Timothy A.; Keeling, Neil

doi:10.1016/j.ijsu.2006.05.013

Cited by 99 publications

(79 citation statements)

References 12 publications

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“…There is evidence that NLR is a good prognostic factor in other cancers, such as colorectal cancer, 14 and it has also been identified as a predictor for postoperative complications following colorectal surgery. 15 In this study, both NLR and CA19.9-bilirubin ratio were found to have high positive predictive values for unresectability (88.9 and 76.5%, respectively). Therefore, both results could have an integral role in the staging process for pancreaticoduodenectomy.…”

Section: Discussionsupporting

confidence: 49%

Surrogate Markers of Resectability in Patients Undergoing Exploration of Potentially Resectable Pancreatic Adenocarcinoma

Ong

Garcea

Thomasset

et al. 2008

Journal of Gastrointestinal Surgery

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Despite extensive preoperative staging, a significant number of pancreatic cancers are unresectable at surgical exploration. Patients undergoing pancreatic exploration with a view to resection were studied and comparisons are then made between those undergoing resection and a bypass procedure to identify surrogate markers of unresectability. One hundred thirteen consecutive patients underwent pancreatic exploration for head-of-pancreas (HOP) adenocarcinoma with curative intent. Fifty-five underwent pancreaticoduodenectomy and 58 underwent a bypass procedure. Student's t test, receiver operator characteristics (ROC) and logistic regression were used to compare the predictive value of preoperative patient variables collected retrospectively. The bypass group had a significantly higher median CA19.9 than the resection group (P = 0.003). Platelet count and neutrophil-lymphocyte ratio (NLR) were also significantly different (P = 0.013 and P = 0.026, respectively). ROC analysis indicated that age < or =65, platelet count >297 x 10(9)/l, CA19.9 < or =473 Ku/l, and CA19.9-bilirubin ratio were predictive variables for resectable disease. NLR and CA19.9-bilirubin ratio had specificity values of 92.9 and 97.0%, respectively. From logistic regression, a raised CA19.9 was found to be an independent risk factor for unresectable disease (P = 0.031). A significant proportion of patients with HOP adenocarcinoma are understaged preoperatively. Preoperative serology including platelet count, NLR, CA19.9, and CA19.9-bilirubin ratio may be used as additional discriminators of resectability particularly for high-risk patients.

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Section: Discussionsupporting

confidence: 49%

Surrogate Markers of Resectability in Patients Undergoing Exploration of Potentially Resectable Pancreatic Adenocarcinoma

Ong

Garcea

Thomasset

et al. 2008

Journal of Gastrointestinal Surgery

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“…NLR can easily be calculated by the ratio of neutrophils to lymphocytes in peripheral blood.It is a very simple and cheap method when compared with the other inflammatory cytokines including IL-6, IL-1b, and TNF-a [8]. In previous studies, increased NLR was demonstrated in cardiovascular and cerebrovascular diseases such as hypertension, unstable angina pectoris, myocardial infarction, transient ischemic attacks and stroke [9][10][11][12][13]. Moreover NLR has been found as a valuable index for predicting clinical outcomes in oncology [14][15][16][17] and inflammatory diseases such as Alzheimer, ulcerative colitis and appendicitis [18][19][20] .…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Neutrophil to Lymphocyte Ratio and Recurrent Aphthous Stomatitis

Özler¹

2016

Ann Clin Anal Med

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ÖzetAmaç: Bu çalışamnın amacı rekürren aftöz stomatitli hastalarda nötrofil lenfosit oranının artıp artmadığını araştırmaktır.Ayrıca,nötrofil lenfosit oranı ile oral ülser aktivitesi arasında korelasyon olup olamadığı araştırılmıştır. Gereç Anahtar KelimelerRekürren Aftöz Stomatit; İnflamasyon; Nötrofil Lenfosit Oranı Abstract Aim: The aim of this study is to investigate whether neutrophil to lymphocyte ratio(NLR) levels are elevated in patients with recurrent aphthous stomatitis(RAS). Moreover, we aimed to find out whether there is a correlation between NLR levels and oral ulcer activity. Material and Method: The study group consisted of 35 subjects with RAS and 35 age and sex matched control subjects. The examination of the subjects included a detailed history, general physical examination and assessment of laboratory blood parameters. Results: The mean NLR values were 2.05 ± 0.63 in RAS group and 1.34 ± 0.48 in the control group. The mean NLR values in the patients with RAS were significantly higher than the control group (p =0.0001).Moreover, there was positive correlation between NLR values and oral ulcer activity (r =0.586, p=0.0001). Discussion: There is no previous study that investigated the relationship between NLR and RAS in the literature. NLR should be taken into account as quick, cheap, easily measurable, new inflammatory marker, instead of other acute-phase proteins.

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“…NLR > 5 values were found to be predictive (6,10). Cook et al (11) found that postoperative NLR predicted complications following colorectal surgery. In that study, NLR > 9.3 on the first postoperative day correlated with an increased risk of complications.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-lymphocyte ratio as a predictive factor for tumor staging in colorectal cancer

Özgehan¹,

Kahramanca²,

Kaya³

et al. 2014

Turk J Med Sci

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Post-operative neutrophil–lymphocyte ratio predicts complications following colorectal surgery

Abstract: NLR > or =9.3 on the first post-operative day is associated with an increased risk of complications. This simple derivation of routinely available data helps to identify patients at high-risk of complications, allowing targeted preventive measures.

Cited by 99 publications

References 12 publications

Surrogate Markers of Resectability in Patients Undergoing Exploration of Potentially Resectable Pancreatic Adenocarcinoma

Surrogate Markers of Resectability in Patients Undergoing Exploration of Potentially Resectable Pancreatic Adenocarcinoma

The Relationship Between Neutrophil to Lymphocyte Ratio and Recurrent Aphthous Stomatitis

Neutrophil-lymphocyte ratio as a predictive factor for tumor staging in colorectal cancer

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