Post-operative pain management in dental implant surgery: a systematic review and meta-analysis of randomized clinical trials

Khouly, Ismael; Braun, Rosalie Salus; Ordway, Michelle; Alrajhi, Mashal; Fatima, Sana; Kiran, Bhupesh; Veitz‐Keenan, Analia

doi:10.1007/s00784-021-03859-y

Cited by 16 publications

(11 citation statements)

References 40 publications

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“…In the present study, no patients reported post-surgery pain, proving that the administration of analgesic drugs as needed could be effective [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 83%

Full Arch Implant-Prosthetic Rehabilitation in Patients with Type I Diabetes Mellitus: Retrospective Clinical Study with 10 Year Follow-Up

D'orto

Polizzi

Nagni

et al. 2022

IJERPH

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The aim of this retrospective clinical study was to evaluate and compare implant survival, marginal bone loss, and clinical and prosthetic complications in healthy patients and patients with type I diabetes undergoing full arch implant-prosthetic rehabilitation. A total of 47 patients needing total fixed rehabilitation of one or both arches were enrolled for this study. Based on the absence of any systemic diseases (Group A) or the presence of type I diabetes (Group B), the sample was divided into two groups. According to the grade of bone atrophy in the posterior region, patients received full arch rehabilitation (of one or both jaws) with 6 axial implants or, if the residual posterior bone height was insufficient, All-on-Four rehabilitation and a total 236 dental implants were placed. Follow-up visits were performed 1 week after surgery, at 3 and 6 months and then once a year for the next 10 years. No statistically significant differences between groups were recorded about implant survival rates, marginal bone loss, or clinical and prosthetic complications. However, concerning complications, post-surgical bleeding and wound infection were recorded in Group A more than in Group B. In cases of compensated diabetes compensation, implant placement could be considered a safe procedure.

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“…In the present study, no patients reported post-surgery pain, proving that the administration of analgesic drugs as needed could be effective [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 83%

Full Arch Implant-Prosthetic Rehabilitation in Patients with Type I Diabetes Mellitus: Retrospective Clinical Study with 10 Year Follow-Up

D'orto

Polizzi

Nagni

et al. 2022

IJERPH

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“…Nonaddictive analgesics, including NSAIDs and acetaminophen, are recommended as first-line agents in the management of pain following outpatient dental procedures (Hersh et al, 2020). Prior studies have demonstrated that prescription doses of NSAIDs are superior to placebo in reducing post-operative pain and swelling following implant placement surgery (Khouly et al, 2021;Mattos-Pereira et al, 2021;Melini et al, 2020). However, to our knowledge, this is the first study to compare the analgesic and anti-inflammatory effects of OTC doses of an NSAID and acetaminophen following implant placement surgery.…”

Section: Discussionmentioning

confidence: 98%

“…Numerous placebo-controlled studies support the use of non-steroidal anti-inflammatory drugs (NSAIDs) as first-line agents in managing pain following outpatient dental procedures due to their effectiveness and lack of addictive potential (Hersh et al, 2020;Moore & Hersh, 2013). Most of these studies have been performed in patients undergoing surgical extraction of bony impacted mandibular third molars, but similar results have been observed in studies of implant placement (Khouly et al, 2021;Mattos-Pereira et al, 2021;Melini et al, 2020). Pre-emptive administration of dexketoprofen 25 mg (Sanchez-Perez et al, 2018), ibuprofen 600 mg (Pereira et al, 2020), or piroxicam 40 mg (Bhutani et al, 2019), 15-60 minutes prior to surgery, resulted in less post-operative pain compared to placebo.…”

Section: Introductionmentioning

confidence: 95%

A Randomized, Double-Blind Trial of the Analgesic and Anti-Inflammatory Effects of Naproxen Sodium and Acetaminophen Following Implant Placement Surgery

Theken

Chen

Wall

et al. 2022

Preprint

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Objectives: The objectives of this study were to compare the analgesic and anti-inflammatory effects of naproxen sodium and acetaminophen after implant placement surgery. Materials and Methods: Adult patients who received one or two dental implants were treated with naproxen sodium (440 mg loading dose + 220 mg q8h, n=15) or acetaminophen (1000 mg q6h - max daily dose 3000 mg, n=15) for three days after implant placement in a randomized, double-blind design. Pain was assessed on a 0-10 scale every 20 minutes for 6 h. Tramadol (50 mg) was available as a rescue medication. Plasma and gingival crevicular fluid (GCF) were collected prior to the surgery and 0, 1, 2, 4, 6, 24, and 72h after surgery for quantification of interleukin (IL)-6, IL-8, and IL-1β levels. Results: Pain scores were significantly lower in patients treated with naproxen sodium compared to those treated with acetaminophen. Inflammatory mediator levels in plasma and GCF increased after surgery and returned to near baseline levels by 72h. Plasma IL-6 levels were significantly lower 6h after surgery in patients treated with naproxen sodium compared to acetaminophen. No differences in inflammatory mediator concentrations in GCF were observed between the treatment groups. Conclusions: Naproxen sodium was more effective than acetaminophen in reducing post-operative pain and systemic inflammation following surgical placement of one or two dental implants. Further studies are needed to determine whether these findings are applicable to more complex implant cases and how they affect clinical outcomes following implant placement.

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“…Titration of postimplant pain control medication explored in Tianjin Medical University Second Hospital before the current study was carried out, and some cases of moderate to severe pain were reported occasionally. Patients who received dental implants would be routinely prescribed NSAID or acetaminophen post surgery when ruling out all the contraindications, which is consistent with the current protocol [ 29 ]. In the current study, no opioid analgesics are getting involved due to the regulations for the dental procedure of opioid analgesic medication application in China.…”

Section: Discussionmentioning

confidence: 99%

Postsurgical Pain and Implant Osseointegration Failure: A Case Control Study

Shang

Gao

Lengas

et al. 2022

International Journal of Dentistry

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Aim. The relationship between postsurgical pain and osseointegration was evaluated and analyzed in this study. Material and method. 27 patients, ranging in age from 35 to 72 years old, 12 males and 15 females, who received dental implants and failed to achieve osseointegration from Tianjin Medical University Second Hospital, were analyzed and studied in the following aspects: bone density, initial torque, one- or two-stage surgery, postsurgical pain, postsurgical swelling, and radiographic evidence of osseointegration failure. Result. 5 patients were assessed to be D4 bone density and 7 cases were assessed to be D3 bone density, 2 patients were assessed to be D2 bone density and 13 patients were assessed to be D1 bone density. All cases were documented with clinically acceptable initial torque. Among the 27 cases, 2 of them were one-stage nonsubmerged surgery and 25 cases were two-stage submerged surgery. 25 out of 27 patients reported moderate to severe pain lasting for more than 72 hours. Radiologic examinations failed to offer any indication of poor osseointegration in the 7-day postsurgical follow-up. Conclusion. Moderate to severe postsurgical pain lasting more than 72 hours displays high odd ratio of poor osseointegrate. The radiological examinations alone failed to offer any valuable evidence for the early detection of osseointegration failure in this study.

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Post-operative pain management in dental implant surgery: a systematic review and meta-analysis of randomized clinical trials

Cited by 16 publications

References 40 publications

Full Arch Implant-Prosthetic Rehabilitation in Patients with Type I Diabetes Mellitus: Retrospective Clinical Study with 10 Year Follow-Up

Full Arch Implant-Prosthetic Rehabilitation in Patients with Type I Diabetes Mellitus: Retrospective Clinical Study with 10 Year Follow-Up

A Randomized, Double-Blind Trial of the Analgesic and Anti-Inflammatory Effects of Naproxen Sodium and Acetaminophen Following Implant Placement Surgery

Postsurgical Pain and Implant Osseointegration Failure: A Case Control Study

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