Post-oral sensing of fat increases food intake and attenuates body weight defense

Gallop, Molly R.; Wilson, Victoria C.; Ferrante, Anthony W.

doi:10.1016/j.celrep.2021.109845

Cited by 7 publications

(4 citation statements)

References 74 publications

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“…Experimental overfeeding studies have also investigated how diets with different fat content affect energy balance [ 55 , 114 , 156 , 157 ]. One study in male C57BL/6 mice showed that overfeeding with a high-fat diet (40.1% of total calories) or an isocaloric low-fat diet (8.6% of total calories) for six weeks caused a similar weight gain [ 156 ].…”

Section: Lessons Learned From Experimental Overfeeding Studies In Ani...mentioning

confidence: 99%

“…On the other hand, these data also indicate that dietary lipid composition does not modulate the body weight gain that is observed in response to overfeeding. However, this latter notion has recently been challenged by an overfeeding study in which intragastric infusion of a highly palatable high-fat liquid diet weakened the defense against weight gain and increased the voluntary intake of a less palatable low-fat diet in male C57BL/6 mice [ 157 ]. This novel finding is consistent with the idea that diets with high fat content promote the development of obesity [ 158 ] and suggests that the obesogenic effect of dietary fat might, at least partly, be attributed to its ability to impair the still unknown physiological mechanisms that protect against an excessive body weight gain.…”

Section: Lessons Learned From Experimental Overfeeding Studies In Ani...mentioning

confidence: 99%

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The physiology of experimental overfeeding in animals

Ranea-Robles

Lund

Clemmensen

2022

Molecular Metabolism

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Section: Lessons Learned From Experimental Overfeeding Studies In Ani...mentioning

confidence: 99%

Section: Lessons Learned From Experimental Overfeeding Studies In Ani...mentioning

confidence: 99%

The physiology of experimental overfeeding in animals

Ranea-Robles

Lund

Clemmensen

2022

Molecular Metabolism

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“…A hypercaloric diet based on carbohydrates has low palatability, so the animals may reduce their body mass instead of increasing it, since animals in nature, once satiated, do not ingest more. On the contrary, a hyperlipidemic diet has better palatability and animals consume it better, thus increasing their body mass [49,50]. Due to the soft texture of the new diets used in this study, wooden blocks were placed in the cages so that the teeth of the mice would wear out and the animals could express their appropriate behaviour.…”

Section: Animals and Experimental Designmentioning

confidence: 99%

Effects of Sulforaphane and Chlorophyl a in a Western Diet-Induced Obesity Model

Martins,

Matos,

Soares

et al. 2023

Obesities

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The global rise in obesity and its co-morbidities raises worldwide health, social and economic concerns, especially in developed countries. Compounds derived from natural sources are now in the focus of pharmacological therapies. In recent years, sulforaphane (SFN) has been the subject of studies due to its anti-cancer, anti-inflammatory, antioxidant and potential anti-obesity effects. Lately, some studies have also reported the anti-obesogenic potential of chlorophyll. In this study, we evaluated the anti-obesity effects of SFN and chlorophyll a (Chlo.a) in C57BL/6J mice fed with a Western diet, rich in sugar and fat. The study lasted 14 weeks, and for the last 4 weeks SFN (0.25 or 0.5 mg/kg/day) or Chlo.a (0.2 or 0.5 mg/kg/day) was administered orally. The results showed that supplementation with SFN or Chlo.a resulted in an increase in body temperature and a reduction in the size of adipocytes. However, the administration of SFN or Chlo.a for 4 weeks did not decrease the body weight gain or hepatic steatosis, and increased hepatic ROS counterbalancing with an increase in SOD activity. In conclusion, in the animal model used, treatment with SFN or Chlo.a did not show strong anti-obesity effects; however, slight improvements were observed with the supplementation of these compounds.

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“…Additionally, several other studies have not found reduced body weight on dark‐phase TRF [75, 81–83]. However, short length of intervention, rats versus mice, and diet composition could account for the differing results (Table 1), as diets of differing fat content have been shown to affect food intake and body weight [84, 85].…”

Section: Energy Balance Under Active‐phase Trf On Hfdmentioning

confidence: 99%

Finding balance: understanding the energetics of time‐restricted feeding in mice

Gallop

Tobin

Chaix

2022

Obesity

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Over the course of mammalian evolution, the ability to store energy likely conferred a survival advantage when food became scarce. A long-term increase in energy storage results from an imbalance between energy intake and energy expenditure, two tightly regulated parameters that generally balance out to maintain a fairly stable body weight. Understanding the molecular determinants of this feat likely holds the key to new therapeutic development to manage obesity and associated metabolic dysfunctions. Time-restricted feeding (TRF), a dietary intervention that limits feeding to the active phase, can prevent and treat obesity and metabolic dysfunction in rodents fed a high-fat diet, likely by exerting effects on energetic balance. Even when body weight is lower in mice on active-phase TRF, food intake is generally isocaloric as compared with ad libitum fed controls. This discrepancy between body weight and energy intake led to the hypothesis that energy expenditure is increased during TRF. However, at present, there is no consensus in the literature as to how TRF affects energy expenditure and energy balance as a whole, and the mechanisms behind metabolic adaptation under TRF are unknown. This review examines our current understanding of energy balance on TRF in rodents and provides a framework for future studies to evaluate the energetics of TRF and its molecular determinants.

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Post-oral sensing of fat increases food intake and attenuates body weight defense

Cited by 7 publications

References 74 publications

The physiology of experimental overfeeding in animals

The physiology of experimental overfeeding in animals

Effects of Sulforaphane and Chlorophyl a in a Western Diet-Induced Obesity Model

Finding balance: understanding the energetics of time‐restricted feeding in mice

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