Post-primary Pulmonary Tuberculosis

Madkour, M. Monir; Abusabaah, Y.; Mousa, Ali Ben; Masoud, A

doi:10.1007/978-3-642-18937-1_20

Cited by 2 publications

(2 citation statements)

References 91 publications

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“…However, in 5-10% of infected individuals the granulomatous sequestering response becomes compromised by decreased immunocompetence due to advancing age, comorbid infection, or malnutrition, and this results in active secondary infection (Cegielski and McMurray, 2004;Phillips and Ernst, 2012). Alternatively, re-infection from an exogenous source may also result in active secondary tuberculosis, although this is clinically less common (Madkour et al, 2004). The majority of secondary tuberculosis infections will affect the lungs, resulting in the formation of additional granulomatous tissue with a necrotic center (Akhtar and Mana, 2004;Madkour et al, 2004).…”

Section: Tuberculosis: Pathogenesis and Functional Impactmentioning

confidence: 99%

“…The tissue necrosis caused by caseating granulomas has devastating effects on the lungs of the host. Secondary pulmonary tuberculosis ("phthisis" or "consumption") is associated with a productive (often bloody) cough, pleural effusion, and progressive respiratory failure (Madkour et al, 2004;Karakousis et al, 2017). Left untreated, disease resolution or death typically occurs within three years (Tiemersma et al, 2011).…”

Section: Tuberculosis: Pathogenesis and Functional Impactmentioning

confidence: 99%

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“Captain of All These Men of Death”: An Integrated Case Study of Tuberculosis in Nineteenth-Century Otago, New Zealand

Snoddy¹,

Buckley²,

King³

et al. 2020

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The South Island of New Zealand saw several major waves of migration in the mid-nineteenth century, predominantly from Europe but also with an ethnically distinct Chinese presence. The rural community of Milton, Otago, was a settler community established primarily by immigrants from the United Kingdom in search of a better quality of life. However, these settlers faced unique challenges related to surviving in an isolated location with very little infrastructure compared to their origin populations. In 2016 excavation was undertaken at St. John's Burial Ground, Milton, with the object of using bioarchaeological methods to elucidate the lived experience of the first organized European settlement of this region, particularly in terms of health and disease. Here we present a case study of Burial 21 (B21), a male individual of known identity and a documented cause of death. We use biochemical and paleopathological methods to ground-truth his written history, which includes a period of invalidism due to tuberculosis, and discuss the implications of our findings for the community, provision of care, and quality of life in rural colonial New Zealand.

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Section: Tuberculosis: Pathogenesis and Functional Impactmentioning

confidence: 99%

Section: Tuberculosis: Pathogenesis and Functional Impactmentioning

confidence: 99%

“Captain of All These Men of Death”: An Integrated Case Study of Tuberculosis in Nineteenth-Century Otago, New Zealand

Snoddy¹,

Buckley²,

King³

et al. 2020

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The Echo of Pulmonary Tuberculosis: Mechanisms of Clinical Symptoms and Other Disease-Induced Systemic Complications

Luies

Preez

2020

Clin Microbiol Rev

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SUMMARY Clinical symptoms of active tuberculosis (TB) can range from a simple cough to more severe reactions, such as irreversible lung damage and, eventually, death, depending on disease progression. In addition to its clinical presentation, TB has been associated with several other disease-induced systemic complications, such as hyponatremia and glucose intolerance. Here, we provide an overview of the known, although ill-described, underlying biochemical mechanisms responsible for the clinical and systemic presentations associated with this disease and discuss novel hypotheses recently generated by various omics technologies. This summative update can assist clinicians to improve the tentative diagnosis of TB based on a patient’s clinical presentation and aid in the development of improved treatment protocols specifically aimed at restoring the disease-induced imbalance for overall homeostasis while simultaneously eradicating the pathogen. Furthermore, future applications of this knowledge could be applied to personalized diagnostic and therapeutic options, bettering the treatment outcome and quality of life of TB patients.

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Post-primary Pulmonary Tuberculosis

Cited by 2 publications

References 91 publications

“Captain of All These Men of Death”: An Integrated Case Study of Tuberculosis in Nineteenth-Century Otago, New Zealand

“Captain of All These Men of Death”: An Integrated Case Study of Tuberculosis in Nineteenth-Century Otago, New Zealand

The Echo of Pulmonary Tuberculosis: Mechanisms of Clinical Symptoms and Other Disease-Induced Systemic Complications

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