Post-radiation epithelioid angiosarcoma of the urinary bladder and prostate

Wang, Gang; Black, Peter C.; Skinnider, Brian; Hayes, Malcolm; Jones, Edward C.

doi:10.5489/cuaj.3220

Cited by 12 publications

(11 citation statements)

References 19 publications

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“…MYC gene amplification is often observed in radiation-associated angiosarcomas and only rarely in de novo angiosarcomas [ 13 , 22 ]. Immunohistochemistry was shown to be a useful surrogate marker for MYC amplification in post-radiation angiosarcoma after treatment for breast carcinomas [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Even within these entities, angiosarcoma of the urinary bladder is an uncommon diagnosis. First described in 1907 by Jungano [ 3 ], only a few cases of angiosarcoma primary to the bladder have been reported so far, most of which associated with previous pelvic radiotherapy ( Table 1 ) [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. Given its biologically aggressive phenotype, prognosis is dismal, with a five-year survival rate between 10% and 35% and common causes of death being local recurrence and distant metastases [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Angiosarcoma of the Urinary Bladder Following Radiotherapy: Report of a Case and Review of the Literature

et al. 2021

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Background and objectives: Angiosarcomas are uncommon and extremely aggressive malignancies derived from vascular endothelial cells. Although they can occur anywhere in the body and at any age, they are more frequently found in the skin of the head and neck regions and in the elderly. Few cases have been recorded in deep soft tissues and in parenchymal organs. Angiosarcomas of the urinary bladder are exceedingly rare. They usually arise in adult patients with a history of radiation therapy, cigarette smoking, or exposure to chemical agents (e.g., vinyl chloride). Despite multidisciplinary treatment approaches combining surgery, radiotherapy, and chemotherapy, prognosis is dismal. Materials and methods: We describe a case of a 78-year-old Caucasian man presenting with a vesical mass incidentally discovered with abdominal computerized tomography (CT). He underwent transurethral resection of the bladder (TURB), and histology was compatible with angiosarcoma. Results: The patient had been a heavy smoker and his medical history included therapeutic irradiation for prostate cancer eight years previously. Radical cystoprostatectomy was feasible, and pathologic examination of the surgical specimen confirmed angiosarcoma involving the urinary bladder, prostate, and seminal vesicles. Post-operative peritonitis resulted in progressive multi-organ failure and death. Conclusions: Angiosarcoma primary to the urinary bladder is seldom encountered, however, it should be considered in the differential diagnosis of vesical tumors, especially in elderly men with a history of pelvic radiotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Angiosarcoma of the Urinary Bladder Following Radiotherapy: Report of a Case and Review of the Literature

et al. 2021

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“…Awareness in the variability of the morphological aspects in a bladder angiosarcoma is very important, as features can be misleading, especially in small biopsy specimens, a situation that initially occurred in our current case. The most important feature of this tumor is blood-filled vascular channels lined by malignant endothelial cells as seen in "classical angiosarcomas", but solid architecture with spindle cells or even a predominant epithelioid morphology may be encountered [1][2][3]9]. Therefore, one must keep in mind the main differential diagnosis of angiosarcomas, (hemangioma, Kaposi's sarcoma, poorly differentiated or sarcomatoid urothelial carcinoma and metastatic melanoma) and use appropriate immunohistochemical panel of stains to make the correct diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Primary bladder angiosarcoma synchronous with prostatic acinar adenocarcinoma in an 82-year-old male

et al. 2020

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Primary bladder angiosarcoma is a rarely encountered and poorly described malignancy. Only 34 cases have been described in the English literature according to PubMed, accounting for only 2% of the genitourinary soft tissue sarcomas and 0.6% of all bladder tumors. We report a case of a primary angiosarcoma of the urinary bladder in an 82-year-old patient and present the clinical history, histopathological and immunohistochemical features of this tumor, in order to provide better understanding of the diagnosis, possible therapies and clinical outcome.

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“…It has also been reported that sarcomas increase their incidence after radiotherapy for prostate carcinoma, being 6% within the radiation field and 2% outside the radiation field ( 11 ). In this regard, few cases of angiosarcoma have been reported following radiotherapy for carcinoma of the prostate ( 12 – 16 ). To the best of our knowledge we describe the first two cases of intra-abdominal angiosarcomas secondary to radiotherapy treatment for prostate carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy‑associated intra‑abdominal angiosarcoma after prostatic adenocarcinoma: Case reports

Domínguez

González

2018

mol clin onc

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Angiosarcoma is a rare soft tissue neoplasm, which accounts for <1% of all soft tissue tumours. It has been previously reported that the incidence rate of angiosarcomas increases following radiotherapy. The present study reports two cases of intra-abdominal angiosarcoma associated with previous radiotherapy treatment. To the best of our knowledge, these associations have not been previously described in English literature. The patients aged 71 and 83 years were admitted to the center for abdominal pain and diarrhea. Each patient had previously had treatment with radiotherapy for prostate adenocarcinoma. During their hospitalization, biopsies were obtained and the diagnosis of angiosarcoma was reached. In each patient the tumors had irregular proliferating vascular channels, lined by atypical endothelial cells, which varied from elongated and spindle-shaped to large and plump. Immunocytochemistry revealed that the tumor cells were positive for the cytoplasmic endothelial markers cluster of differentiation (CD)31 and CD34. The recognition of these associations is important and their occurrence in this rare type of neoplasm should not mislead the pathologist and cause a misdiagnosis of the sarcoma.

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Post-radiation epithelioid angiosarcoma of the urinary bladder and prostate

Cited by 12 publications

References 19 publications

Angiosarcoma of the Urinary Bladder Following Radiotherapy: Report of a Case and Review of the Literature

Angiosarcoma of the Urinary Bladder Following Radiotherapy: Report of a Case and Review of the Literature

Primary bladder angiosarcoma synchronous with prostatic acinar adenocarcinoma in an 82-year-old male

Radiotherapy‑associated intra‑abdominal angiosarcoma after prostatic adenocarcinoma: Case reports

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