Post-radiation pelvic sarcomas after radiotherapy treatment of prostate adenocarcinoma

López-Torres, Irene Isabel; Calvo-Haro, José Antonio; Mediavilla-Santos, Lydia; Pérez-Mañanes, Rubén; Cuervo-Dehesa, Miguel; Vaquero, Javier

doi:10.5455/aces.20170921120541

Cited by 3 publications

(9 citation statements)

References 24 publications

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“…In March 2015 Chao et al [6] shows a complications rate of 35.1% that is less rate than the previously series that show complications rate of 75% in 1995 by Apffelstaedt [7]. Recently, our group has published his experience in this field [8].…”

Section: Discussionmentioning

confidence: 85%

Radiation-Induced Intrapelvic Osteosarcoma Treated with Radical Pelvic Surgery: Case Report and Literature Review

Lozano¹

2019

SCTI

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Osteosarcoma is a rare but serious sequel of radiotherapy. Surgery used to be the main treatment option in those cases in which inbloc radical resection was possible. Surgical management of these tumors must take into consideration the possibility of complete resection and surgeries impact the patient's quality of life. Reconstructive surgery after tumor removal is still controvertial but technically feasible when the tumor is located in the pelvis bone. We present the case of radiation-induced intrapelvic osteosarcoma centered on the right acetabulum with radiological criteria of aggressiveness affecting the hip joint and extending to adjacent soft tissues of the right hemipelvis with suspected internal stop infiltration and isquicoccigeo muscle. Surgery in-bloc resection of the mass performing a total internal hemipelvectomy involving the ilium and the whole of the acetabulum, ischium, pubis and the head of femoral bone were done. Reconstructive pelvic surgery was done with allograft bone inserted in the remainder of the ilium with plates and screws. Multidisciplinary approach to treat pelvic bone sarcoma consist on general surgeon, orthopedic surgeon, plastic surgeon, radiologist and oncologist could be safe and result in good functional results and overall survival.

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Section: Discussionmentioning

confidence: 85%

Radiation-Induced Intrapelvic Osteosarcoma Treated with Radical Pelvic Surgery: Case Report and Literature Review

Lozano¹

2019

SCTI

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“…Post-radiation sarcoma is defined as the appearance of a sarcoma within the field of previous therapeutic irradiation, histologically different from the treated tumor [1][2][3][4], and the tissue where the secondary tumor originates had to be metabolically normal prior to irradiation [4]. Time must elapse between the date of exposure to radiation and the development of a secondary cancer, but the latency period is not well defined [2][3][4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Sarcomas are among the first solid tumors to be associated with this radiotherapy exposure [1], but the risk of developing sarcoma following radiotherapy is estimated to be less than 1% [1,2,3,6,8]. In prostate cancer patients treated by radiotherapy, one in 70 patients with prostate cancer treated with radiotherapy will develop a secondary tumor if they survive more than 10 years, but only 0.16% are considered therapy induced [1]. As radio-induced neoplasm in case of radiotherapy for prostate cancer, bladder and rectal cancer are the most frequent [4,7], penile sarcomas are extremely rare with only few cases reported in the literature [4].…”

Section: Discussionmentioning

confidence: 99%

“…Radio-induced neoplasms seem to increase with a longer latency period [4,7], and advanced age could also be a risk factor [2,8]. Some authors suggest that there is no relationship established between radiation dose and appearance of radiationinduced sarcoma [1,2]. But a few studies do suggest higher rates of post-radiation sarcoma with higher doses of radiation [1,2,3,6].…”

Section: )mentioning

confidence: 99%

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Sarcoma of the Penis Following Pelvic Radiotherapy for Prostate Cancer: A Case Report

2024

Ann Case Report

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We present a case report of an 82-year-old patient with a history of prostate cancer treated by prostatectomy, radiotherapy, and hormonal therapy. He developed afterwards an indurated penile mass with urinary obstruction. Biopsy confirmed the diagnosis of leiomyosarcoma. Radiotherapy is a well-known risk factor for sarcomas. Post-radiation sarcoma is defined as the appearance of a sarcoma within the field of previous therapeutic irradiation, histologically different from the treated tumor. The latency period is not well defined, but a long latency period is considered as a risk factor for sarcoma, as well as advanced age, and lymphedema. The relationship between radiation dose and sarcoma risk remains debated. Leiomyosarcoma of the penis is very rare and can present with symptoms of dysuria or urinary obstruction. Post radiation sarcomas are hard to treat, and surgical treatment remains a mainstay of treatment. The prognosis varies depending on tumor location and size but is often poorer compared to sporadic primary sarcomas. Secondary malignancies after radiotherapy are a growing problem because of the increased number of long-term cancer survivors, and it should be included in management discussion. Further studies on the risk and latency period are required to develop better strategies for patient care.

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Management of late events after conventional radical prostate radiotherapy: against the odds of secondary tumours and recurrence of prostate cancer

Montero-Feijoo

La³

et al. 2021

BMJ Case Rep

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We present two 85-year-old men, with a similar history of prostate cancer treated more than 10 years ago with radiotherapy, who were in remission, but sought medical care at a time, due to alarm sign and symptoms. Case 2 resulted in a locally advanced secondary radiation-induced sarcoma of the penile base. Case 1 suffered from a round, 2 cm soft-tissue lesion with spiculated borders at the ureterovesical junction responsible for ipsilateral iliac vein compression and urinary obstruction without proven biochemical prostate cancer relapse, raising concerns about recurrence or secondary tumour. Both patients followed an oncological geriatric assessment and were ‘vulnerable’ at their presentation. Hence, we describe the effort to perform medical care adequacy regarding patient’s frailty and the anatomic locations within the prior radiation field. In case 2, we got a pathological diagnose and followed sequential multimodal treatments without success. But in case 1, minimal intervention resulted in improvement.

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Post-radiation pelvic sarcomas after radiotherapy treatment of prostate adenocarcinoma

Cited by 3 publications

References 24 publications

Radiation-Induced Intrapelvic Osteosarcoma Treated with Radical Pelvic Surgery: Case Report and Literature Review

Radiation-Induced Intrapelvic Osteosarcoma Treated with Radical Pelvic Surgery: Case Report and Literature Review

Sarcoma of the Penis Following Pelvic Radiotherapy for Prostate Cancer: A Case Report

Management of late events after conventional radical prostate radiotherapy: against the odds of secondary tumours and recurrence of prostate cancer

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