Post-recurrence survival in patients with cervical cancer

Cibula, David; Dostálek, Lukáš; Jarkovský, Jiří; Mom, Constantijne H.; López, Aldo; Falconer, Henrik; Scambia, Giovanni; Ayhan, Ali; Kim, Sarah H.; Ortiz, David Isla; Klát, Jaroslav; Obermair, Andreas; Martino, Giampaolo Di; Pareja, René; Manchanda, Ranjit; Kosťun, Ján; Reis, Ricardo dos; Meydanlı, Mehmet Mutlu; Odetto, Diego; Laky, R; Zapardiel, Ignacio; Weinberger, Vít; Benešová, Klára; Borčinová, Martina; Cárdenas, Fernando; Wallin, Emelie; Anchora, Luigi Pedone; Akıllı, Hüseyin; Abu‐Rustum, Nadeem R.; Barquet-Muñoz, Salim Abraham; Javůrková, Veronika; Fischerová, D.; Lonkhuijzen, Luc van

doi:10.1016/j.ygyno.2021.12.018

Cited by 19 publications

(10 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…With the rapid economic and social development and the change of people's living habits, the exposure factors of CC are increasing day by day [ 13 ]. Surgical resection is the preferred treatment for CC, but a review of the data shows that there is still a certain risk of recurrence after surgery [ 14 ]. At present, there are two major bottlenecks in treatment: one is the immature early diagnosis method, and the other is the low survival rate of advanced cancer treatment.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Role and Mechanism of ZEB1 in Regulating Cervical Carcinoma Progression via Modulating PD-1/PD-L1 Checkpoint

Lin

Wang

2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

Background. Cervical carcinoma (CC) is a common and highly malignant tumor in women. The involvement of zinc finger E-box binding homeobox 1 (ZEB1) in many kinds of tumors has been well-documented; however, its role and mechanism in CC remain to be clarified. Objective. This study investigated the mechanism of ZEB1 in modulating the growth and metastasis of CC cells. Methods. The expression of ZEB1 in CC tissues and adjacent normal counterparts was determined by reverse transcription-polymerase chain reaction (RT-PCR). The correlation between ZEB1 and patient clinicopathological indexes was analyzed. In vitro, gain and loss functions of ZEB1 were performed in C-33A and HeLa cell lines. The proliferation, migration, and invasion of CC cells were detected by Cell Counting Kit-8 (CCK-8) assay and transwell assay, respectively. The expression levels of apoptosis-related proteins such as BCL2-associated X (Bax), B-cell lymphoma-2 (Bcl2), and Caspase-3, as well as epithelial-mesenchymal transition (EMT)-associated proteins including E-cadherin, Vimentin, and Snail, were measured by Western blotting. In addition, the targeting relationship between ZEB1 and programmed death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) was predicted by bioinformatics and further verified by dual-luciferase reporter assay. Results. ZEB1 was significantly up-regulated in CC tissues compared with normal counterparts. ZEB1 overexpression promoted the migration, proliferation, and invasion of CC cells and inhibited apoptosis, while knocking down ZEB1 contributed to the opposite effects. In addition, experiments on related mechanisms confirmed that ZEB1 targeted the 3’EUTR terminal of PD-1/PD-L1 and negatively regulated its expression. And an interaction between ZEB1 and PD-1/PD-L1 was identified. Conclusion. ZEB1 can promote the proliferation and metastasis of CC cells via modulating the PD-1/PD-L1 checkpoint.

show abstract

Section: Discussionmentioning

confidence: 99%

Analysis of the Role and Mechanism of ZEB1 in Regulating Cervical Carcinoma Progression via Modulating PD-1/PD-L1 Checkpoint

Lin

Wang

2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

show abstract

“…To the best of our knowledge, this rate is the highest for the detection of asymptomatic recurrence, overall survival after recurrence, asymptomatic recurrence, and symptomatic recurrence (HR, 4.28; 95% CI, 1.87–9.78; p < 0.001). A recent study with a large cohort of 4343 patients with stage I and II cervical cancer demonstrated that asymptomatic recurrence was a significant factor for survival after recurrence [ 16 ]. In contrast, a review of 17 retrospective studies in which follow-up visit intervals were every 3–4 months in the first 2 years did not show any benefit in detecting asymptomatic recurrence [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Utility of vaginal vault cytology in the local recurrence of cervical cancer

et al. 2023

View full text Add to dashboard Cite

Background In Japan, 8000 women were newly diagnosed with cervical cancer in 2018. The healthcare insurance policy in Japan allows physicians to utilize vaginal volt cytology tests and serum biomarker measurement at every visit and imaging analysis at an adequate interval with screening for recurrence after initial treatment. However, the major surveillance guidelines published in the United States and European countries recommend focusing on pelvic examinations and symptom reviews to avoid unnecessary tests. This study aimed to reassess the benefits of standard surveillance methods adopted in this study by retrospective analysis. Methods From January 2009 to December 2015, the medical records of patients with recurrence who were initially diagnosed with International Federation of Gynecology and Obstetrics stage I–III cervical cancer were collected for this study. Clinicopathological data were statistically analyzed to identify significant factors. In the first 2 years, the patients underwent regular surveillance, including pelvic examination, serum tumor marker tests, vaginal vault cytology every 1–3 months, and imaging analysis at 6- to 12-month intervals. In the following 2 years, the patients received a regular check with the same methods every 4 months and an annual imaging analysis. Afterward, the patients had regular screening every 6 to 12 months. Results In the study period, 84 of the 981 patients experienced recurrence, and 88.1% had an asymptomatic recurrence. The disease-free interval was not related to the recurrence site. In univariate analysis, primary treatment, recurrence site, and diagnostic method were significant factors for survival outcomes. In contrast, multivariate analysis indicated that only primary treatment was a significant factor. In patients with local recurrence, multivariate analysis demonstrated that radiation as salvage therapy was an independent predictive factor for overall survival after recurrence. Conclusions In this retrospective study, routine imaging analysis and serum biomarker measurement did not contribute to patient prognosis after recurrence. In contrast, vaginal vault cytology can improve survival after recurrence in some patients. Tailored surveillance methods based on individual disease conditions and treatment modalities can improve post-recurrent survival outcomes.

show abstract

“…Forty-four percent of cervical cancer patients are diagnosed with early-stage disease, for which the 5-year overall survival rate is 91.9% 10. Recurrence rates after radical hysterectomy range from 5% to 26%; 48.4% of recurrences are diagnosed within 2 years, while 77.7% are diagnosed within 5 years after treatment 11–14. Most recurrences are local,15 and the most common sites of distant recurrences are the liver (16%), lungs (14%), bones (9.2%), and large bowel (7.2%) 16…”

Section: Introductionmentioning

confidence: 99%

Peritoneal carcinomatosis after minimally invasive surgery versus open radical hysterectomy: systematic review and meta-analysis

Hoegl¹,

Viveros‐Carreño

Palacios

et al. 2022

Int J Gynecol Cancer

Self Cite

View full text Add to dashboard Cite

ObjectiveTo assess the incidence of peritoneal carcinomatosis in patients undergoing minimally invasive or open radical hysterectomy for cervical cancer.MethodsThe MEDLINE (accessed through Ovid), Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Clinical Trials, and Scopus databases were searched for articles published from inception up to April 2022. Articles published in English were considered. The included studies reported on patients with International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IA-IIA squamous cell carcinoma, adenocarcinoma, and/or adenosquamous carcinoma of the cervix who underwent primary surgery. Studies had to report at least one case of peritoneal carcinomatosis as a recurrence pattern, and only studies comparing recurrence after minimally invasive surgery versus open surgery were considered. Variables of interest were manually extracted into a standardized electronic database. This study was registered in PROSPERO (CRD42022325068).ResultsThe initial search identified 518 articles. After the removal of the duplicate entries from the initial search, two authors independently reviewed the titles and abstracts of the remaining 453 articles. Finally, 78 articles were selected for full-text evaluation; 22 articles (a total of 7626 patients) were included in the analysis—one randomized controlled trial and 21 observational retrospective studies. The most common histology was squamous cell carcinoma in 60.9%, and the tumor size was <4 cm in 92.8% of patients. Peritoneal carcinomatosis pattern represented 22.2% of recurrences in the minimally invasive surgery approach versus 8.8% in open surgery, accounting for 15.5% of all recurrences. The meta-analysis of observational studies revealed a statistically significant higher risk of peritoneal carcinomatosis after minimally invasive surgery (OR 1.90, 95% CI 1.32 to 2.74, p<0.05).ConclusionMinimally invasive surgery is associated with a statistically significant higher risk of peritoneal carcinomatosis after radical hysterectomy for cervical cancer compared with open surgery.

show abstract

Post-recurrence survival in patients with cervical cancer

Cited by 19 publications

References 25 publications

Analysis of the Role and Mechanism of ZEB1 in Regulating Cervical Carcinoma Progression via Modulating PD-1/PD-L1 Checkpoint

Analysis of the Role and Mechanism of ZEB1 in Regulating Cervical Carcinoma Progression via Modulating PD-1/PD-L1 Checkpoint

Utility of vaginal vault cytology in the local recurrence of cervical cancer

Peritoneal carcinomatosis after minimally invasive surgery versus open radical hysterectomy: systematic review and meta-analysis

Contact Info

Product

Resources

About