Post–Renal Transplant Cytomegalovirus Infection: Study of Risk Factors

Kute, VivekB; Vanikar, A. V.; Shah, Parth; Gumber, Manoj R.; Patel, Hardik; Godara, Suraj; Munjappa, Bipin; Sainaresh, VV; Engineer, Divyesh; Jain, S.H.; Modi, Pranjal; Shah, Vaishal; Trivedi, Varsha B; Trivedi, HL

doi:10.1016/j.transproceed.2011.12.025

Cited by 28 publications

(18 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There was a statistical significance between pre-transplant diabetes and CMV infection in the allograft recipients. Diabetes was the commonest comorbid condition for post-renal transplant CMV infection in another Indian study also (15). Our study did not identify any significant association of CMV with acute rejection.…”

Section: Cytomegaloviruscontrasting

confidence: 53%

“…A recent study from Turkey revealed positive hepatitis B and C serology in 17.6% of CMV positive cases (14). Another study found HCV positivity in 28.6% of CMV positive recipients (15). We noted a statistical significance of post-transplant bacterial UTIs which developed in 6 out of 7 patients (85.7 %) who immunohistochemically tested positive for CMV.…”

Section: Cytomegalovirussupporting

confidence: 47%

See 1 more Smart Citation

Prevalence of cytomegalovirus and BK polyoma virus infection in post-renal transplant patients in a tertiary care centre in

Manuel¹,

Ambroise²,

Varghese³

et al. 2017

J Nephropathol

View full text Add to dashboard Cite

Background: Viral infections are a significant cause of graft loss and dysfunction in kidney transplant recipients. Cytomegalovirus and BK polyomavirus have often been explained as the most common viral etiological agents. Objectives: The current study was undertaken to assess the prevalence of cytomegalovirus and BK polyomavirus infection in post-renal transplant individuals in a tertiary care centre in South India and also to study the histopathological changes of such infections in the kidney allograft biopsies. Patients and Methods:We conducted a retrospective investigation of 100 cases using archival renal biopsy specimens which were subjected to immunohistochemical stains to detect cytomegalovirus and BK polyoma virus. These findings were then correlated with the histopathological alterations detected in H&E sections. Results: We detected the prevalence of cytomegalovirus in 7% and BK polyoma virus in 3%. Cytomegalovirus was statistically associated with pre-and post-transplant infections along with diabetic status. We noted that, out of the seven patients who were immunohistochemically cytomegalovirus positive, only five had positive cytomegalovirus IgM status. With BK polyoma virus, we noted a statistical significance with pre-and posttransplant infections. However, we did not find evidence of cytomegalovirus and BK polyoma virus co-infection in any of the renal allograft biopsies. Conclusions: Routine immunohistochemical evaluation of cytomegalovirus and BK polyoma viral infections in kidney allograft recipients must be done, especially in those with preand post-transplant infections and diabetes.

show abstract

Section: Cytomegaloviruscontrasting

confidence: 53%

Section: Cytomegalovirussupporting

confidence: 47%

Prevalence of cytomegalovirus and BK polyoma virus infection in post-renal transplant patients in a tertiary care centre in

Manuel¹,

Ambroise²,

Varghese³

et al. 2017

J Nephropathol

View full text Add to dashboard Cite

show abstract

“…Previous studies examined risk factors for CMV disease in transplant recipients. Factors such as CMV serostatus (CMV‐seronegative recipients from CMV‐seropositive donors [D+/R−]), allograft rejection, advanced age, immunomodulatory factors associated with HLA matching, retransplantation, and the use of deceased vs. living‐related donors all influence the incidence of CMV infection . Our study showed that deceased‐donor KT and advanced age were significantly associated with tissue‐invasive CMV infection.…”

Section: Discussionmentioning

confidence: 83%

Cytomegalovirus infection after acute rejection therapy in seropositive kidney transplant recipients

Lee

Kim

Han

et al. 2014

Transplant Infectious Dis

View full text Add to dashboard Cite

show abstract

“…Intensification of immunosuppression to prevent or treat graft rejection is therefore an established risk factor for CMV replication (2). Intensification of immunosuppression to prevent or treat graft rejection is therefore an established risk factor for CMV replication (2).…”

mentioning

confidence: 99%

Cytomegalovirus Serology and Replication Remain Associated With Solid Organ Graft Rejection and Graft Loss in the Era of Prophylactic Treatment

et al. 2014

View full text Add to dashboard Cite

show abstract

Post–Renal Transplant Cytomegalovirus Infection: Study of Risk Factors

Cited by 28 publications

References 13 publications

Prevalence of cytomegalovirus and BK polyoma virus infection in post-renal transplant patients in a tertiary care centre in

Prevalence of cytomegalovirus and BK polyoma virus infection in post-renal transplant patients in a tertiary care centre in

Cytomegalovirus infection after acute rejection therapy in seropositive kidney transplant recipients

Cytomegalovirus Serology and Replication Remain Associated With Solid Organ Graft Rejection and Graft Loss in the Era of Prophylactic Treatment

Contact Info

Product

Resources

About