Post–Renal Transplantation Bone Health in Children Evaluated by Means of Quantitative Ultrasound and Densitometry

González-Jorge, A.L.; Enciso, Sandra; Reyes, A.; Hernández, Araceli Muñoz; Ortíz, Lourdes; Aldana, Ruth; Velásquez-Forero, Francisco; Ambrosi, Regina; Clark, Patricia; Mendez, Lucas C.; Rivas-Ruíz, Rodolfo; Medeiros, Mara

doi:10.1016/j.transproceed.2016.02.025

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…In new appraisal of their results, their findings are in disagreements with some other studies. 51,52 The main cause may be the decrease of cortical thickness (measured by phalanx) while overall density, measured by DXA, demonstrates less change. However, the current study findings are not very different from previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…Due to importance of secondary osteoporosis, it would seem vital to look at the potential for QUS to assist in defining bone changes, due to underlying disease, in comparison with healthy ones and the power to differ between normal and secondary osteoporotic patients. However, there is conflicting data about QUS abilities 41,47–56 ; therefore, this was tested in a convenient sample of patients.…”

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confidence: 99%

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Quantitative Ultrasound of Phalanx in Primary and Secondary Osteoporosis: Mini-review and Practical Experience

Najafi

Mahdavi‐Mazdeh

et al. 2022

Journal of Diagnostic Medical Sonography

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Objective: Dual x-ray absorptiometry (DXA) is gold standard of bone densitometry, but quantitative ultrasound (QUS) of bone is less expensive and portable. This study was designed to assess its usefulness in secondary osteoporosis diagnosis. Materials and Methods: There were 200 secondary osteoporosis cases (rheumatoid arthritis, hemodialysis, kidney transplant patients, and levothyroxine users) and of those, their phalanx QUS results were compared with normal controls. Also, the QUS and DXA results were compared to find any correlation of these methods for diagnosing osteoporosis. Results: There was not significantly different results compared with normal controls, except for those of hemodialysis patients ( P = .00). Also, the comparison of QUS with DXA results showed no significant correlation except in hemodialysis patients, in both spinal and femoral regions ( P = .023 and .21, respectively), as well as the levothyroxine group’s spinal region ( P = .005). Conclusion: These results suggest that QUS of phalanx may be useful in screening secondary osteoporosis but for establishment of diagnosis, DXA measurements are still needed.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Quantitative Ultrasound of Phalanx in Primary and Secondary Osteoporosis: Mini-review and Practical Experience

Najafi

Mahdavi‐Mazdeh

et al. 2022

Journal of Diagnostic Medical Sonography

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“…Gonzalez-Jorge et al conducted a study, based on DXA measurements at LS and TB and QUS at radius in a group of children, assessed shortly after kidney transplantation [24]. The highest percentage of patients with a significant degree of impaired bone mineralization was identified with TB-BMD.…”

Section: Discussionmentioning

confidence: 99%

Skeletal status assessment by quantitative ultrasound and bone densitometry in children with different renal conditions

2018

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SummaryTwo methods of skeletal status assessment—quantitative ultrasound (QUS) and densitometry (DXA)—were applied and compared in a group of children with different renal disorders. Skeletal assessments in children with different renal conditions should rather not be based on a single diagnostic tool. Lumbar spine DXA is very effective to reveal disturbances secondary to glucocorticoids, whereas total body DXA and QUS are both better in identification of disturbances related to decreased GFR.IntroductionThe aim of the study was to evaluate the skeletal status in children in different stages of chronic kidney disease (CKD) or treated with glucocorticoids, using either densitometry (DXA) or quantitative ultrasound (QUS) methods.MethodsSeventy-six subjects (27 girls/49 boys) at the mean age of 11.8 ± 4.0 years were enrolled to the reported study. They were divided into three subgroups: with normal glomerular filtration rate (GFR) but treated with glucocorticoids (GCs, n = 38), with decreased GFR (CKD 2–5, n = 26) and with normal GFR and without any bone-toxic treatment (CKD 1, n = 12). DXA scans were carried out at lumbar spine (LS) and at total body (TB), and quantitative ultrasound (QUS) imaging was done at hand phalanges. QUS results were compared to those obtained from 310 healthy matched controls.ResultsThe average Z-score for LS-BMD and TB-BMD was below zero in all the study subgroups. Neither were there any significant differences in the mean Z-score for LS among the subgroups. The mean Z-score for TB was significantly the lowest in the CKD 2–5 subgroup. The percentage of subjects with TB Z-score ≤ − 2.0 was the highest in the CKD 2–5 subgroup (69.2%), whereas the percentage of subjects with LS Z-score ≤ − 2.0 was the highest in the GC subgroup (23.7%). QUS results in CKD 2–5 were significantly lower than those in the controls, whereas the results, obtained in GC and CKD 1 subgroups, were similar to those in healthy subjects.ConclusionsSkeletal status assessment in children and adolescents with different renal conditions should not be based on single diagnostic approach. DXA scanning, performed at lumbar spine, is potentially more appropriate to reveal disturbances secondary to long-term GC therapy, whereas TB-DXA is highly effective in the identification of skeletal disturbances related to decreased kidney function. QUS at hand phalanges seems to be a useful diagnostic means in CKD with diminished GFR but insufficient to detect GC-related disturbances.

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Post–Renal Transplantation Bone Health in Children Evaluated by Means of Quantitative Ultrasound and Densitometry

Cited by 2 publications

References 12 publications

Quantitative Ultrasound of Phalanx in Primary and Secondary Osteoporosis: Mini-review and Practical Experience

Quantitative Ultrasound of Phalanx in Primary and Secondary Osteoporosis: Mini-review and Practical Experience

Skeletal status assessment by quantitative ultrasound and bone densitometry in children with different renal conditions

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