Post-reperfusion syndrome in patients with ischemic heart disease after coronary stenting.

Abstract

Post-reperfusion syndrome is a chronic multi-factorial syndrome, caused by restoration of coronary blood flow of de novo in patients after coronary stenting. Pathophysiological processes occurring in stenting segment (incomplete endothelization of vessel, excessive regeneration of neointima, formation of neoatherosclerosis) the risk of partial or total stent thrombosis due to the low level of compliance of the patient, as well as local changes in blood flow to the myocardium and modification of hemodynamics in stented arteries have a significant impact on the clinical course and prognosis of the disease. In contrast to the syndrome of reperfusion occurring after restoration of blood flow in the infarct-dependent coronary artery syndrome and postischemic reperfusion syndrome in patients with acute myocardial infarction after spontaneous or therapeutic thrombolysis, post-reperfusion syndrome is characterized by prolonged course (months and years). Clinical symptoms depend of the localization of pathological process (in stented arteries or in other non-stented arteries of the heart), as well as the presence of comorbidity and the factors of risk of the coronary heart disease.

Myocardial condition in overweight patients at different stages of rehabilitation after revascularization

“…Широкое применение реконструктивных и интервенционных методов, обеспечивающее восстановление кровотока в питающих миокард артериях, позволило добиться прогресса в лечении ССЗ. В то же время последующие этапы реабилитации обнаружили серьезные проблемы, возникающие вследствие ремоделирования сердца и развивающихся постреперфузионных осложнений [7].…”