Post San Antonio Breast Cancer Symposium

Abstract

The 2016 SABCS (San Antonio Breast Cancer Symposium) provided delegates with a number of interesting and some praxis-changing data. This issue of memo highlights the most relevant data from the SABCS presented by leading breast cancer experts from Austria.Locoregional issues are addressed by Michael Hubalek [1]. He presents data regarding sentinel node biopsy after neoadjuvant therapy from the GANEA trial in patients with clinical node-negative disease. Then Hubalek shows data with a protease-activatable radiometric fluorescent peptide dye conjugate (AVB-620) to identify malignant tissue intraoperatively and a poster from Denmark showing data of radioisotopic seed localisation technique for nonpalpable lesions. There were new interesting data regarding radiotherapy and breast reconstruction and a study regarding MRI for surgical planning.Regarding systemic treatment in the adjuvant setting, Marija Balic [2] presents three prospective trials using extended endocrine therapy (DATA, IDEAL, NS-ABP-B42) with unexpected results, at least for some of us. The use of bisphosphonates in adjuvant therapy has been addressed in the TEAMIIb trial and Balic also presents data of patients with HER2-enriched breast cancer in the neoadjuvant (NSABP-B52; standard treatment with or without endocrine therapy) and in an adjuvant setting (only stage I; APT trial using paclitaxel weekly as backbone as well as adjuvant TDM1 versus trastuzumab using pertuzumab in both groups). Balic also shows a poster from the MINDACT trial comparing immunohistochemical with genomic subtype classification suggesting that the KI67 might