Post-Stroke Depression and Cognitive Aging: A Multicenter, Prospective Cohort Study

Shin, Moon Sam; Sohn, Min Kyun; Lee, Jongmin; Kim, Deog Young; Shin, Yong‐Il; Oh, Gyung-Jae; Lee, Yang Soo; Joo, Min Cheol; Lee, So Young; Song, Min-Keun; Han, Junhee; Ahn, Jeonghoon; Lee, Younghoon; Chang, Won Hyuk; Shin, Seyoung; Choi, Soo Mi; Lee, Seon Kui; Kim, Yun-Hee

doi:10.3390/jpm12030389

Cited by 12 publications

(6 citation statements)

References 31 publications

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“…Therefore, these results may not be applicable to older post-stroke patients. In fact, for older post-stroke patients, depression could be more deleterious for cognition in men than in women [78]. We also did not investigate the influence of health status and stroke complications [79] including menopause, level of fatigue, sleep problems and disorders, fever or recent infection, seizures, hemineglect, hyperglycemia, and other cardiac/respiratory/hepatic medical conditions, which could also play a role in the severity of depression and neuropsychological performance, as well as their changes and relationship.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Post-Stroke Depressive Symptoms on Cognitive Performance in Women and in Men: A 4 Month Prospective Study

Sobreiro

Terroni

Mattos

et al. 2023

Life

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Background: Depressive symptoms have been associated with cognitive impairment after stroke, and women may be specifically affected. Objective: The aim of this study was to investigate gender-specific characteristics in the relationship between changes in depression severity and changes in cognitive performance after stroke. Methods: We prospectively evaluated 73 patients without a previous history of depression in the first and fourth months after a first ischemic stroke. The severity of depressive symptoms was assessed using the 31-item version of the Hamilton Rating Scale for Depression, and executive function, attention, working memory, and verbal fluency were assessed using a neuropsychological battery. Results: We included 46 (63.0%) men and 27 (36.9%) women, with mean ages of 55.2 (SD ± 15.1) and 46.8 (SD ± 14.7) years, respectively. We found significant improvement in the digit span forward and Stroop dots from month 1 to month 4 post stroke for both men and women. Women, but not men, presented a correlation between changes in phonemic verbal fluency and changes in the 31-item version of the Hamilton Rating Scale for Depression scores. Improvement in depression was correlated with improvement in verbal fluency, and worsening in depression was correlated with worsening in verbal fluency. Conclusions: Our results suggest that women might be more vulnerable to the relationship between depressive symptoms and cognitive performance, and improvement of depression may be necessary for women’s improvement in phonemic verbal fluency from the first to the fourth month after a stroke. We did not adjust the results for multiple comparisons. Thus, our findings might be considered preliminary, and confirmatory studies, also focusing on specific characteristics of women that could explain these differences, are warranted.

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Section: Discussionmentioning

confidence: 99%

The Impact of Post-Stroke Depressive Symptoms on Cognitive Performance in Women and in Men: A 4 Month Prospective Study

Sobreiro

Terroni

Mattos

et al. 2023

Life

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“…Health-related factors included BMI, alcohol consumption, smoking, physical activity (walking), muscle training, stress level, and depression. BMI was calculated by dividing weight (kg) by height (m) squared using the available anthropometric measurements, and based on the WHO criteria, it was classified into underweight (<18.5 kg/m 2 ), normal (18.5 to <25 kg/m 2 ), and overweight and obese (≥25 kg/m 2 ) [ 31 ]. Alcohol consumption was defined as the intake of alcohol more than once a month on average for the past year, and smoking status was classified into non-smoker, ex-smoker, and current smoker.…”

Section: Methodsmentioning

confidence: 99%

Association between depression and quality of life in stroke patients: The Korea National Health and Nutrition Examination Survey (KNHANES) IV–VII (2008–2018)

Sun

Lee

et al. 2022

PLoS ONE

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Background Stroke and depression are common diseases that affect quality of life (QoL). Although some recent studies have investigated the association between the two diseases, studies that examined the association between stroke, depression, and QoL are rare, with large-scale national-level studies lacking. We aimed to investigate the association between depression and QoL in stroke patients. Methods Data from the Korea National Health and Nutrition Examination Survey (KNHANES) IV–VII conducted in 2008–2018 were used, and 45,741 adults who were aged >40 years and had no missing data for stroke and depression were included in the analysis. The participants were first grouped by prevalence of stroke, and further divided by prevalence of depression. Results The overall prevalence of stroke was 3.2%, and the incidence was 9% higher in men than in women. Multiple logistic regression was performed after adjusting for demographic factors, health-related factors, and disease-related factors. The results confirmed that the stroke group with depression had a lower overall health-related quality of life, measured using EQ-5D, score compared to the stroke group without depression (-0.15). Moreover, the concurrent stroke and depression treatment group had the highest OR of 7.28 (95% CI 3.28–16.2) for the anxiety/depression domain. Conclusion Depression was strongly associated with QoL in stroke patients. This association was more evident in stroke patients undergoing treatment for depression. Thus, clinical approaches that take QoL into consideration are needed for stroke patients with depression.

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“…Post-stroke depression (PSD) is a psychological disorder characterized by persistent depression, decreased interest and behavioral withdrawal after stroke ( 1 , 2 ). The main manifestations are psychiatric symptoms, such as insomnia, depression and low self-esteem, and even suicidal tendencies, which can lead to cognitive impairment ( 3 , 4 ). Nosologically, PSD is a special type of depression that lacks clear concept and diagnostic criteria at present.…”

Section: Introductionmentioning

confidence: 99%

Effect of acupuncture combined with antidepressants on post-stroke depression: A network meta-analysis of nine acupuncture therapy

Chen

Liu

et al. 2023

Front. Neurol.

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BackgroundPost-stroke depression (PSD) is a common psychiatric complication of mental disorders after stroke. Acupuncture for PSD is effective and has few adverse effects. As a classical complementary and alternative therapy, acupuncture is often used in combination with antidepressants for PSD. However, there is a wide variety of acupuncture therapies, and the efficacy of different acupuncture varies. In this study, a network meta-analysis (NMA) was used to assess the clinical efficacy of different acupuncture combined with antidepressants for the treatment of PSD.MethodsA comprehensive search of PubMed, The Cochrane Library, EMbase, Web of Science, CNKI, CBM, VIP, and Wan-Fang databases for published randomized controlled trials of acupuncture combined with antidepressants for the treatment of PSD was conducted. The time frame for the literature search was from the date of database creation to April 30, 2022. The Cochrane risk of bias tool for randomized trials (RoB 2.0) was used to evaluate the bias risk of the included studies. Data analysis was performed by STATA 14.0 software.ResultsA total of 38 literatures with 2,898 patients involving nine acupuncture therapies were included. NMA results were as follows: moxibustion plus antidepressants had the best efficacy in terms of improving total effective rate. Conventional acupuncture plus antidepressants was the most effective in improving HAMD scores. In terms of improving SDS scores, acupressure plus antidepressants was the most effective. In terms of improving NIHSS scores, moxibustion plus antidepressants showed the best results.ConclusionA comparison of the efficacy indicators of the nine different acupuncture therapies combined showed that moxibustion plus antidepressants, conventional acupuncture plus antidepressants and acupressure plus antidepressants were superior in the treatment of PSD. Based on the shortcomings of the existing studies, this conclusion needs to be validated by additional high-quality randomized controlled trials.

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Post-Stroke Depression and Cognitive Aging: A Multicenter, Prospective Cohort Study

Cited by 12 publications

References 31 publications

The Impact of Post-Stroke Depressive Symptoms on Cognitive Performance in Women and in Men: A 4 Month Prospective Study

The Impact of Post-Stroke Depressive Symptoms on Cognitive Performance in Women and in Men: A 4 Month Prospective Study

Association between depression and quality of life in stroke patients: The Korea National Health and Nutrition Examination Survey (KNHANES) IV–VII (2008–2018)

Effect of acupuncture combined with antidepressants on post-stroke depression: A network meta-analysis of nine acupuncture therapy

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