Post-stroke fatigue is associated with impaired processing speed and memory functions in first-ever stroke patients

Pihlaja, Riikka; Uimonen, Jenni; Mustanoja, Satu; Tatlısumak, Turgut; Poutiainen, Erja

doi:10.1016/j.jpsychores.2014.08.011

Cited by 57 publications

(79 citation statements)

References 32 publications

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“…While fatigue correlated with attentional and executive function, neither correlated with lesion location. Another independent investigation105 confirmed poor executive and memory functions in high PSF in the first 6 months after stroke. They also showed that side and size of lesion did not correlate with presence of PSF.…”

Section: Mechanisms Of Psfmentioning

confidence: 83%

Mechanisms of poststroke fatigue

Doncker

Dantzer

Ormstad

et al. 2017

J Neurol Neurosurg Psychiatry

104

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Section: Mechanisms Of Psfmentioning

confidence: 83%

Mechanisms of poststroke fatigue

Doncker

Dantzer

Ormstad

et al. 2017

J Neurol Neurosurg Psychiatry

104

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“…14,21,[26][27][28][30][31][32][33][34] PSF may be less common in married people (compared with single people) and in those living at home (compared with those living in an institution), 16 but these findings have not been widely replicated. 20,21,24,30 Patients with PSF are more often unemployed or more likely to change their jobs than those without PSF, 14,21 but cause-and-effect relationships remain unclear.…”

Section: Demographic Factorsmentioning

confidence: 99%

“…Patients with PSF are less likely to return to their previous work. 21,22,29,34 Neurological/Physical Deficits Physical impairment and functional deficits are important contributors to PSF. 14,16,21,35,36 Patients who suffer a stroke experience worse fatigue than patients who suffer a transient ischemic attack.…”

Section: Demographic Factorsmentioning

confidence: 99%

“…51 Medications that are commonly used in patients with stroke such as sedatives, 27 antidepressants, 45,52 and hypnotics 17 may cause fatigue. Although studies have not implicated medications as a major cause of PSF, 14,34,47 the potential association should not be ignored.…”

Section: Medical Comorbidities Smoking and Medicationsmentioning

confidence: 99%

“…A cross-sectional study showed that attention deficits are associated with PSF. 22 Others found that processing speed was correlated with mental fatigue at 3 and 6 months after stroke 34,83,84 and that memory dysfunction was related to PSF at 6 months after stroke. 34 Thus, although PSF is not likely to be associated with general e162 Stroke July 2017…”

Section: Cognitive Impairmentmentioning

confidence: 99%

See 2 more Smart Citations

Poststroke Fatigue: Emerging Evidence and Approaches to Management: A Scientific Statement for Healthcare Professionals From the American Heart Association

Hinkle¹,

Becker²,

Kim³

et al. 2017

Stroke

142

129

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At least half of all stroke survivors experience fatigue; thus, it is a common cause of concern for patients, caregivers, and clinicians after stroke. This scientific statement provides an international perspective on the emerging evidence surrounding the incidence, prevalence, quality of life, and complex pathogenesis of poststroke fatigue. Evidence for pharmacological and nonpharmacological interventions for management are reviewed, as well as the effects of poststroke fatigue on both stroke survivors and caregivers.

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No add‐on effect of tDCS on fatigue and depression in chronic stroke patients: A randomized sham‐controlled trial combining tDCS with computerized cognitive training

et al. 2022

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Background Fatigue and emotional distress rank high among self‐reported unmet needs in life after stroke. Transcranial direct current stimulation (tDCS) may have the potential to alleviate these symptoms for some patients, but the acceptability and effects for chronic stroke survivors need to be explored in randomized controlled trials. Methods Using a randomized sham‐controlled parallel design, we evaluated whether six sessions of 1 mA tDCS (anodal over F3, cathodal over O2) combined with computerized cognitive training reduced self‐reported symptoms of fatigue and depression. Among the 74 chronic stroke patients enrolled at baseline, 54 patients completed the intervention. Measures of fatigue and depression were collected at five time points spanning a 2 months period. Results While symptoms of fatigue and depression were reduced during the course of the intervention, Bayesian analyses provided evidence for no added beneficial effect of tDCS. Less severe baseline symptoms were associated with higher performance improvement in select cognitive tasks, and study withdrawal was higher in patients with more fatigue and younger age. Time‐resolved symptom analyses by a network approach suggested higher centrality of fatigue items (except item 1 and 2) than depression items. Conclusion The results reveal no add‐on effect of tDCS on fatigue or depression but support the notion of fatigue as a relevant clinical symptom with possible implications for treatment adherence and response.

show abstract

Post-stroke fatigue is associated with impaired processing speed and memory functions in first-ever stroke patients

Cited by 57 publications

References 32 publications

Mechanisms of poststroke fatigue

Mechanisms of poststroke fatigue

Poststroke Fatigue: Emerging Evidence and Approaches to Management: A Scientific Statement for Healthcare Professionals From the American Heart Association

No add‐on effect of tDCS on fatigue and depression in chronic stroke patients: A randomized sham‐controlled trial combining tDCS with computerized cognitive training

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