Post-stroke hemiparesis: Does chronicity, etiology, and lesion side are associated with gait pattern?

Gama, Gabriela Lopes; Lucena, Larissa Coutinho de; Brasileiro, Ana Carolina de Azevedo Lima; Silva, Emília Márcia Gomes de Souza; Galvão, Élida Rayanne Viana Pinheiro; Maciel, Álvaro Campos Cavalcanti; Lindquist, Ana Raquel Rodrigues

doi:10.1080/10749357.2017.1304865

Cited by 11 publications

(5 citation statements)

References 46 publications

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“…The neurological impairments were produced due to the critical damage of brain regions by I/R injury. Stroke-induced gait impairment is one of the clinically relevant indicators of motor dysfunction (Gama et al, 2017). In ischemic rats, severe neurological deficits were present.…”

Section: Discussionmentioning

confidence: 99%

Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke

Ali

Tabassum

Parveen

et al. 2019

Disease Models &Amp; Mechanisms

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A dopamine D2 receptor agonist, pramipexole, has been found to elicit neuroprotection in patients with Parkinson’s disease and restless leg syndrome. Recent evidence has shown that pramipexole mediates its neuroprotection through mitochondria. Considering this, we examined the possible mitochondrial role of pramipexole in promoting neuroprotection following an ischemic stroke of rat. Male Wistar rats underwent transient middle cerebral artery occlusion (tMCAO) and then received pramipexole (0.25 mg and 1 mg/kg body weight) at 1, 6, 12 and 18 h post-occlusion. A panel of neurological tests and 2,3,5-triphenyl tetrazolium chloride (TTC) staining were performed at 24 h after the surgery. Flow cytometry was used to detect the mitochondrial membrane potential, and mitochondrial levels of reactive oxygen species (ROS) and Ca2+, respectively. Mitochondrial oxidative phosphorylation was analyzed by oxygraph (oxygen electrode). Western blotting was used to analyze the expression of various proteins such as Bax, Bcl-2 and cytochrome c. Pramipexole promoted the neurological recovery as shown by the panel of neurobehavioral tests and TTC staining. Post-stroke treatment with pramipexole reduced levels of mitochondrial ROS and Ca2+ after ischemia. Pramipexole elevated the mitochondrial membrane potential and mitochondrial oxidative phosphorylation. Western blotting showed that pramipexole inhibited the transfer of cytochrome c from mitochondria to cytosol, and hence inhibited the mitochondrial permeability transition pore. Thus, our results have demonstrated that post-stroke administration of pramipexole induces the neurological recovery through mitochondrial pathways in ischemia/reperfusion injury.

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Section: Discussionmentioning

confidence: 99%

Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke

Ali

Tabassum

Parveen

et al. 2019

Disease Models &Amp; Mechanisms

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“…Further, our participants did not show knee flexion deviations or demonstrate decreased plantarflexion of the affected side during the stance phase, both of which are commonly observed in patients with stroke. Future studies should include a large number of patients with various gait patterns30 ) . Second, joint kinematic parameters focused on joint angles of the affected side.…”

Section: Discussionmentioning

confidence: 99%

The relationship between trunk acceleration parameters and kinematic characteristics during walking in patients with stroke

Yen

Chang

et al. 2019

J Phys Ther Sci

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[Purpose] Limited literature has investigated the relationships between acceleration-based gait characteristics and kinematic information from motion analysis systems in gait analysis. The purpose of this study is to determine whether acceleration-based gait characteristics were associated with gait characteristics by motion analysis systems in patients with stroke. [Participants and Methods] Seventeen patients with stroke walked along a 10-m-long walkway at their comfortable speed. Trunk acceleration was measured with an accelerometer. Several reflective markers over bony landmarks on the lower extremities were used to capture movements. We evaluated the correlations of variables calculated between the trunk accelerometers and the motion analysis system. [Results] Walking speed was positively correlated with harmonic ratios along the anteroposterior axis and stride regularity along the vertical and anteroposterior axes. Harmonic ratios were associated with the stance phase percent on the unaffected side. Stride regularity was associated with the stance phase percent on both sides. Smaller interstride variability was associated with smaller peak ankle plantarflexion during both phases and greater peak ankle dorsiflexion during swing phase. Stride regularity is positively associated with maximal knee flexion during swing phase. [Conclusion] Relationships with spatiotemporal and joint kinematic parameters from the motion analysis system support the potential use of accelerometers.

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“…Although it is generally believed that hemorrhagic stroke survivors have better neurological and functional prognoses than ischemic stroke survivors, a recent study highlighted that data are mixed [ 40 ], with studies indicating better results in hemorrhagic [ 30 , 37 , 41 , 42 ], in ischemic [ 43 ] or even no differences between the two subtypes [ 44 ]. Finally, some studies showed that specific gait characteristics were associated to lesion etiology [ 45 , 46 ], strongly suggesting that subtype of stroke should be considered as a factor in gait assessment and rehabilitation protocols and therefore in establishing clinical studies focusing on RAGT.…”

Section: Introductionmentioning

confidence: 99%

Hemorrhagic versus ischemic stroke: Who can best benefit from blended conventional physiotherapy with robotic-assisted gait therapy?

et al. 2017

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Post-stroke hemiparesis: Does chronicity, etiology, and lesion side are associated with gait pattern?

Cited by 11 publications

References 46 publications

Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke

Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke

The relationship between trunk acceleration parameters and kinematic characteristics during walking in patients with stroke

Hemorrhagic versus ischemic stroke: Who can best benefit from blended conventional physiotherapy with robotic-assisted gait therapy?

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