Post-stroke insomnia in community-dwelling patients with chronic motor stroke: Physiological evidence and implications for stroke care

Sterr, Annette; Kühn, Marion; Nissen, Christoph; Ettine, D; Funk, Sharon; Feige, Bernd; Umarova, Roza; Urbach, Horst; Weiller, Cornelius; Riemann, Dieter

doi:10.1038/s41598-018-26630-y

Cited by 44 publications

(36 citation statements)

References 52 publications

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“…"More down MCAO18" genes were also enriched with genes involved in the regulation of circadian rhythm (such as Cry2, Rorb, Per3). An impact of ischemic stroke on circadian rhythm has been observed before 68 and our results suggest that aged animals may be more susceptible to its destabilization, which is linked to sleep, mood and post-stroke depression, and may therefore impact recovery 69,70 . Overall, analysis of age-stroke interacting genes revealed an increased neuroinflammatory environment in aged animals, which is connected to higher infiltration and activation of peripheral immune cells, pro-inflammatory cytokine secretion and activation of signaling pathways (ERk/MAPK, type-I interferon) that may contribute to secondary injury.…”

Section: Functional Annotation Of Genes With Different Quantitativementioning

confidence: 51%

Decoding the transcriptional response to ischemic stroke in young and aged mouse brain

Androvic

Kirdajová

Tureckova

et al. 2019

Preprint

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Section: Functional Annotation Of Genes With Different Quantitativementioning

confidence: 51%

Decoding the transcriptional response to ischemic stroke in young and aged mouse brain

Androvic

Kirdajová

Tureckova

et al. 2019

Preprint

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“…35 In a study utilizing polysomnography and Multiple Sleep Latency Tests 12 months after stroke, sleep latencies were longer and sleep efficiency was worse among motor-impaired, right hemisphere stroke patients compared with age and sex-matched controls. 36 These findings were not related to SDB or periodic limb movements, which did not differ between the groups. Insomnia has also been associated with higher rates of incident stroke and worse post-stroke outcome.…”

Section: Sleep-wake Cycle Disturbance and Strokementioning

confidence: 74%

Sleep and Stroke

Khot

Morgenstern

2019

Stroke

106

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Stroke is the leading cause of serious long-term disability in the US, leaving less than half of survivors able to return directly home. 1 Stroke recurrence, estimated as high as 17% over 5 years, also remains unacceptably high. 1 The use of lytic drugs and endovascular devices have revolutionized the care of select stroke patients in the acute setting. However, enormous challenges remain in changing the trajectory of stroke recovery for the vast majority of patients who do not qualify or remain disabled after these treatments, and also in preventing the accumulating disability associated with stroke recurrence. The role of sleep disorders in stroke outcome and recurrence has become a pressing question. Despite estimates of greater than 50% prevalence of sleep disorders after stroke, only about 6% of stroke survivors are offered formal sleep testing and an estimated 2% complete such testing in the 3-month post-stroke period. 2 The reasons for the low rate of screening are at least partly related to the lack of awareness regarding sleep disorders among stroke providers (Figure 1). This review evaluates the role of sleep disorders, including sleep disordered breathing (SDB) and sleep-wake cycle disorders, in stroke etiology and examines the impact of their treatment on stroke outcome. Physiology and anatomy of breathing during sleep During sleep, ventilation is reduced compared to wake, in parallel with the restorative and toning-down changes that occur to heart rate, temperature and blood pressure. Volitional or behavioral input on breathing are absent during sleep; only brainstem neurons, peripheral chemoreceptors and respiratory muscle afferents regulate breathing. 3 Groups of chemoreceptive neurons in the brainstem, including those of the dorsolateral pons, nucleus solitarius and ventral medullary respiratory column, respond to changes in the partial pressure of carbon dioxide and oxygen and thereby serve as a pacemaker regulating the breathing rhythm. 4 Along with effects on the breathing pattern, these brainstem neurons cause a reduction in the upper airway tone at sleep onset through reduced activity of airway dilator muscles, especially the genioglossus, which forms the bulk of the tongue. 3 Alternatively, the chemoreceptive neurons of the brainstem can detect increased carbon

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“…Effects of combined treatment with alprazolam and bailemian on the sleep quality of the patients after stroke were analyzed by Wang et al The post-stroke insomnia is a very common symptom, albeit the treatment is often ignored (10). Alprazolam was discovered to improve the sleep efficiency and decrease the arousal times, rapid eye movement (REM) sleep and sleep latency, whereas bailemian significantly improved the sleep efficiency, total sleep time and the duration of N3.…”

mentioning

confidence: 99%

Editorial: Sleep and Mood Disorders

Verkhratsky

Steardo

2020

Front. Psychiatry

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Editorial on the Research Topic Sleep And Mood DisordersSleep occupies almost one third of our life and it is necessary for survival of all species, including man. There is little doubt that sufficient, restorative sleep plays a critical role in maintaining physical and mental health. Evaluation of a good sleep always includes its quality, timing, quantity and rhythm. Sleep disturbances, including hypersomnia, insomnia, or irregular sleep patterns, result in various cognitive impairments and mood disorders (1, 2). Prolonged sleep deprivation or chronic sleep abnormalities are risk factors for the major depressive disorder (MDD) (3) and bipolar disorder (BD) (4), whereas disturbed sleep appears as a key symptom of mental diturbances (5, 6). Mechanisms connecting sleep deprivation and mood disorders remain, however, unclear.The current Research Topic represents a collection of papers investigating the relationship between sleep abnormalities and mood disorders, as well as studies analyzing potential mechanisms connecting these pathologies. As described in the review by Steardo et al., the worldwide prevalence of sleep disorders is about 50% with even higher occurrence in psychiatric population. Sleep abnormalities are frequently associated with BD and are often a good predictor of a mood disorders. In this review, the alterations in the structure or duration of sleep are considered in all stages of BD. In particular the role of neuroglia in BD and the contributions of the different types of glial cells to BD and sleep abnormalities are discussed in depth. Specially, astrocytes are suggested to have an important role to the pathophysiology of BD through the loss of glial support and neuroprotection in disease-specific regions (7,8). Furthermore, neuroglia cells are also reported to be a key target for the drugs used for the treatment of BD.In the article by Li Y. et al., the relationship between stressful life events and sleep quality is discussed. The effects of stress on the sleep quality was investigated on more than 1,000 college students from a single province in China high correlation between scores of stressful life events and sleep quality has been reported. These results demonstrate that stressful life events can disturb the sleep quality of college students directly and indirectly, through rumination. The latter is defined as a response style that an individual tends to repeatedly think about the problematic situations being focused on negative emotions (9). Increasing psychological resilience could decrease both the direct and indirect effects stressful life events.

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Post-stroke insomnia in community-dwelling patients with chronic motor stroke: Physiological evidence and implications for stroke care

Cited by 44 publications

References 52 publications

Decoding the transcriptional response to ischemic stroke in young and aged mouse brain

Decoding the transcriptional response to ischemic stroke in young and aged mouse brain

Sleep and Stroke

Editorial: Sleep and Mood Disorders

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