BACKGROUNDPyoderma gangrenosum (PG) is a noninfectious inflammatory condition of the skin that results in rapidly progressing necrotic, ulcerative lesions. 1,2 It is rare, affecting three to 10 patients per million, and is often misdiagnosed as an infection. 3,4 PG is a clinical diagnosis of exclusion and can only be made after infection, vasculitis, and neoplasm have been ruled out. 5 Although underlying systemic inflammation, neutrophil malfunction, and genetic predispositions are thought to be linked to the development of PG, the exact cause is