Post-synthetic modifications in porous organic polymers for biomedical and related applications

Kim, Ji Hyeon; Kang, Dong Won; Yun, Hongyeol; Kang, Min‐Jung; Singh, Nem; Kim, Jong Seung; Hong, Chang Seop

doi:10.1039/d1cs00804h

Cited by 100 publications

(48 citation statements)

References 69 publications

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“…Although redox‐switchability in COFs brings it robust reactivity to oxidizing substances in the microenvironment, poor water dispersibility and intracellular uptake efficiency remain to hinder its in vivo application. [ 33 ] The reason behind this is that COFs, are usually constructed by rigid aromatic hydrocarbon linkers with hydrophobic ones, thus, a pre‐ or postsynthetic modification using hydrophilic sidechains must be done. To overcome this question, the surface engineering of COFs was accomplished by PDA coating for enhancing hydrophilia, biocompatibility, and oxidation resistance.…”

Section: Resultsmentioning

confidence: 99%

An Optimally Designed Engineering Exosome–Reductive COF Integrated Nanoagent for Synergistically Enhanced Diabetic Fester Wound Healing

Sun

Wang

et al. 2022

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Oxidative stress and local overactive inflammation have been considered major obstacles in diabetic wound treatment. Although antiphlogistic tactics have been reported widely, they are also challenged by pathogen contamination and compromised angiogenesis. Herein, a versatile integrated nanoagent based on 2D reductive covalent organic frameworks coated with antibacterial immuno‐engineered exosome (PCOF@E‐Exo) is reported to achieve efficient and comprehensive combination therapy for diabetic wounds. The E‐Exo is collected from TNF‐α‐treated mesenchymal stem cells (MSCs) under hypoxia and encapsulated cationic antimicrobial carbon dots (CDs). This integrated nanoagent not only significantly scavenges reactive oxygen species and induces anti‐inflammatory M2 macrophage polarization, but also stabilizes hypoxia‐inducible factor‐1α (HIF‐1α). More importantly, the PCOF@E‐Exo exhibits intriguing bactericide capabilities toward Gram‐negative, Gram‐positive, and drug‐resistant bacteria, showing favorable intracellular bacterial destruction and biofilm permeation. In vivo results demonstrate that the synergetic impact of suppressing oxidative injury and tissue inflammation, promoting angiogenesis and eradicating bacterial infection, could significantly accelerate the infected diabetic fester wound healing with better therapeutic benefits than monotherapy or individual antibiotics. The proposed strategy can inspire further research to design more delicate platforms using the combination of immunotherapy with other therapeutic methods for more efficient ulcerated diabetic wounds treatments.

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Section: Resultsmentioning

confidence: 99%

An Optimally Designed Engineering Exosome–Reductive COF Integrated Nanoagent for Synergistically Enhanced Diabetic Fester Wound Healing

Sun

Wang

et al. 2022

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“…Other polymers, such as porous organic polymers, and the importance of postsynthetic modifications, have been discussed by Kim et al, and these materials could prove to be promising in bioapplications. Alongside Poly( α - L -glutamic acid) (PGA),these polypeptides can also be exploited for theirbiomedical use, which has been discussed by zhang et al, as they have superior properties and a unique structure [ 109 , 110 ]. Some generalized structures of the remaining polymer-based nanohybrids are given in Figure 9 .…”

Section: Other Polymer-based Nanohybridsmentioning

confidence: 99%

Polymer-Based Hybrid Nanoarchitectures for Cancer Therapy Applications

et al. 2022

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Globally, cancer is affecting societies and is becoming an important cause of death. Chemotherapy can be highly effective, but it is associated with certain problems, such as undesired targeting and multidrug resistance. The other advanced therapies, such as gene therapy and peptide therapy, do not prove to be effective without a proper delivery medium. Polymer-based hybrid nanoarchitectures have enormous potential in drug delivery. The polymers used in these nanohybrids (NHs)provide them with their distinct properties and also enable the controlled release of the drugs. This review features the recent use of polymers in the preparation of different nanohybrids for cancer therapy published since 2015 in some reputed journals. The polymeric nanohybrids provide an advantage in drug delivery with the controlled and targeted delivery of a payload and the irradiation of cancer by chemotherapeutical and photodynamic therapy.

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“…47 Furthermore, enzymes and biomolecules are also inevitable biological stimuli; 48 for example, folic acid (FA) has been used as a targeted delivery ligand and therapeutic agent because of its high affinity for folate receptors. 49,50 These features of POPs provide some possibilities for special functions in sensors, packaging, absorption, and separation. In particular, in the biomedical engineering field, stimuli-responsive POPs are emerging as promising anticancer therapeutic materials.…”

Section: Introductionmentioning

confidence: 99%

Porous organic polymers for drug delivery: hierarchical pore structures, variable morphologies, and biological properties

et al. 2022

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Post-synthetic modifications in porous organic polymers for biomedical and related applications

Abstract: Porous organic polymers (POPs) are prepared by crosslinked polymerization of multidimensional rigid aromatic building blocks followed by PSM depending on the application.

Cited by 100 publications

References 69 publications

An Optimally Designed Engineering Exosome–Reductive COF Integrated Nanoagent for Synergistically Enhanced Diabetic Fester Wound Healing

An Optimally Designed Engineering Exosome–Reductive COF Integrated Nanoagent for Synergistically Enhanced Diabetic Fester Wound Healing

Polymer-Based Hybrid Nanoarchitectures for Cancer Therapy Applications

Porous organic polymers for drug delivery: hierarchical pore structures, variable morphologies, and biological properties

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