Post-training intracranial self-stimulation facilitates a hippocampus-dependent task

Soriano‐Mas, Carles; Redolar-Ripoll, Diego; Aldavert-Vera, Laura; Morgado-Bernal, Ignacio; Segura-Torres, Pilar

doi:10.1016/j.bbr.2004.11.025

Cited by 40 publications

(21 citation statements)

References 30 publications

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“…4 In humans, hypothalamic DBS recently has been used to treat cluster headache and even aggressiveness. 5,6 We used hypothalamic DBS in an investigational study to treat a patient with morbid obesity and observed, quite unexpectedly, that stimulation spontaneously evoked detailed autobiographical memory events.…”

Section: Annmentioning

confidence: 99%

Memory enhancement induced by hypothalamic/fornix deep brain stimulation

Hamani

McAndrews

Cohn

et al. 2008

Annals of Neurology

468

347

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Bilateral hypothalamic deep brain stimulation was performed to treat a patient with morbid obesity. We observed, quite unexpectedly, that stimulation evoked detailed autobiographical memories. Associative memory tasks conducted in a double-blinded "on" versus "off" manner demonstrated that stimulation increased recollection but not familiarity-based recognition, indicating a functional engagement of the hippocampus. Electroencephalographic source localization showed that hypothalamic deep brain stimulation drove activity in mesial temporal lobe structures. This shows that hypothalamic stimulation in this patient modulates limbic activity and improves certain memory functions.

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Section: Annmentioning

confidence: 99%

Memory enhancement induced by hypothalamic/fornix deep brain stimulation

Hamani

McAndrews

Cohn

et al. 2008

Annals of Neurology

468

347

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show abstract

“…It has been demonstrated that deep brain stimulation of the hypothalamus in experimental animals can influence aggressiveness, food intake, metabolic rate, and memory (Ban, 1966;Ruffin and Nicolaidis, 1999;Soriano-Mas et al, 2005;Paxinos and Watson, 2007;Sani et al, 2007). Studies of this kind form the basis for therapeutic hypothalamic deep brain stimulation (DBS) in the treatment of refractory cluster headaches and impulsive violent behavior (Franzini et al, 2005;Leone et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

The anatomy of the Göttingen minipig hypothalamus

Ettrup¹,

Sørensen²,

Bjarkam³

2010

Journal of Chemical Neuroanatomy

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“…DBS in central thalamus could lead to a complicated situation in arousal, behavior, and cognition [149][150][151]. With regard to the lateral hypothalamus, the post-training ICSS (the intracranial self-stimulation) could enhance the hippocampus-dependent memories via improving molecular and cellular mechanisms associated with synaptic plasticity, neurogenesis, and neuroprotection [152][153][154][155].…”

Section: Other Brain Regionsmentioning

confidence: 99%