Post-transcriptional modifications and “Calmodulation” of voltage-gated calcium channel function: Reflections by two collaborators of David T Yue

Soong, Tuck Wah; Mori, Masayuki

doi:10.1080/19336950.2015.1051271

Search citation statements

Order By: Relevance

Paper Sections

Select...

Trafficking Regulation Of Vgccs By Other Interacting Protein1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2017

2022

Publication Types

Select...

Article1

Book1

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fact that CaM associates with virtually all HVA channels has led the proposal that this protein might be considered as an integral component of the Ca 2 + channel complex per se [93], and prompted some authors to propose the term 'calmodulation' to cover any kind of CaM-dependent regulation of ion channels. The multifaceted regulation of VGCCs by CaM has extensively been reviewed over the past 2 years [94][95][96]. In this section, we focus exclusively on its specific role in the trafficking of the channel complex.…”

Section: Trafficking Regulation Of Vgccs By Other Interacting Proteinmentioning

confidence: 99%

Trafficking of neuronal calcium channels

Weiss

Zamponi

2017

Neuronal Signaling

View full text Add to dashboard Cite

Neuronal voltage-gated calcium channels (VGCCs) serve complex yet essential physiological functions via their pivotal role in translating electrical signals into intracellular calcium elevations and associated downstream signalling pathways. There are a number of regulatory mechanisms to ensure a dynamic control of the number of channels embedded in the plasma membrane, whereas alteration of the surface expression of VGCCs has been linked to various disease conditions. Here, we provide an overview of the mechanisms that control the trafficking of VGCCs to and from the plasma membrane, and discuss their implication in pathophysiological conditions and their potential as therapeutic targets.

show abstract