Post‐transfusion white cell count in the sick preterm neonate

Wright, Ian; Skinner, Adrian

doi:10.1046/j.1440-1754.2001.00589.x

Cited by 11 publications

(10 citation statements)

References 8 publications

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“…The unchanged values for the total white blood cell count 48 h after transfusion are in agreement with the findings of Fenwick et al 2 . and Wright and Skinner 3 . Both groups described an early leucocytosis which returned to the pre‐transfusion baseline 24 h after transfusion.…”

Section: Discussionsupporting

confidence: 90%

“…This leucocytosis was accounted for by increased neutrophils. Recently, Wright and Skinner reported on a mild white blood cell increase in the first 8 h following transfusion in sick preterm neonates 3 . They also found a significant decrease in neutrophil left‐shift when comparing paired samples taken before transfusion and at any time in the 24 h post‐transfusion.…”

mentioning

confidence: 93%

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Transfusion in premature infants impairs production and/or release of red blood cells, white blood cells and platelets

Frey

2002

J Paediatrics Child Health

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Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 93%

Transfusion in premature infants impairs production and/or release of red blood cells, white blood cells and platelets

Frey

2002

J Paediatrics Child Health

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“…It has been shown that besides sex‐linked deficiency, an autosomal locus is also involved in favism, since not all G6PD deficient develops favism during exposure . Blood transfusion is a usual answer to hemolysis of RBC in this condition …”

Section: Resultsmentioning

confidence: 99%

“…13 Blood transfusion is a usual answer to hemolysis of RBC in this condition. 14 By the end of the study, we hypothesized that cytokines produced by leukocytes are triggered by the beans and might play role in the onset of leukocytosis. This condition can be seen similar to sepsis, that is characterized by a state of "cytokine storm," in which numerous anti-inflammatory and inflammatory mediators are released such as IL-6 and IL-8.…”

Section: What This Paper Adds?mentioning

confidence: 99%

Leukocytosis in patients with favism and association with blood transfusion

Faraji-Goodarzi

Taee

Bajelan

et al. 2019

Clinical Laboratory Analysis

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IntroductionLeukocytosis is a condition marked by abnormal increase in leukocyte count due to an inflammatory response as a defense against most of the infections, or bone tumors; including leukemia. The aim of this study is to analyze the effect of blood transfusion in leukocytosis patients with favism as compared to patients treated with antibiotics or combination of both. MethodsA total of 97 patients with favism who were referred to the University hospital in 2016‐2017 were studied.Key findingsThese patients experienced acute hemolysis following beans meal. These patients were either treated with blood transfusion, antibiotics or combination of both. ConclusionsThis study shows that blood transfusion is an effective therapeutic option for the treatment of leukocytosis. Antibiotics are not deemed necessary for the treatment and blood transfusion alone, can decrease leukocytes to the normal level.

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“…(8) A mild demarginating response also has been reported in preterm infants after red cell transfusions. (9) …”

Section: Effect Of Common Clinical Interventionsmentioning

confidence: 99%

Developmental Defects in Neutrophils from Preterm Infants

et al. 2007

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Michie, and Maheshwari did not disclose any financial relationships relevant to this article. Objectives After completing this article, readers should be able to: 1. Define key neutrophil functions and involved mechanisms. 2. Identify developmental defects in preterm neutrophils. 3. Describe the effect on neutrophils of clinical interventions, such as the use of recombinant myeloid growth factors and drugs commonly used in the neonatal intensive care unit. AbstractNeutrophil development starts in the early second trimester in the human fetus and continues through the rest of the gestation. Preterm birth can interrupt the maturation of fetal neutrophils and place the preterm neonate at risk of life-threatening infections. Various developmental defects have been identified in preterm neutrophils, such as in the ability of circulating neutrophils to cross the endothelial barrier and abnormalities in chemotaxis, respiratory burst, and degranulation. The availability of recombinant human myeloid growth factors has renewed interest in understanding the mechanisms and natural history of such defects. In this article, we review various aspects of the developmental immaturity of preterm neutrophils.

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Post‐transfusion white cell count in the sick preterm neonate

Abstract: A mild post-transfusion white cell increase occurs in sick neonates. Because of the magnitude of effect, it is unlikely that this interesting physiological response would interfere with the diagnosis of sepsis in this population.

Cited by 11 publications

References 8 publications

Transfusion in premature infants impairs production and/or release of red blood cells, white blood cells and platelets

Transfusion in premature infants impairs production and/or release of red blood cells, white blood cells and platelets

Leukocytosis in patients with favism and association with blood transfusion

Developmental Defects in Neutrophils from Preterm Infants

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