Post‐transfusional vs. sporadic non‐A, non‐B chronic hepatitis. A clinico‐pathological and evolutive study

Jové, J.; Sánchez-Tapias, José M.; Bruguera, Miguel; Mas, Antoni; Costa, Josep; Barrera, J.M.; Rodés, Joan

doi:10.1111/j.1600-0676.1988.tb00965.x

Cited by 19 publications

(2 citation statements)

References 11 publications

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“…The sporadic HNANB group (defined as not associated with transfusions or illicit self-injections) in this study were histologically followed for a mean of 44 months, when 41% had CAH and 23% signs of cirrhosis. In agreement with this, JovC et al found that 28% of patients with sporadic chronic NANB hepatitis exhibited a biopsy consistent with CAH after a mean follow-up of 15 months (15). None of the patients of Jove et al, however, developed cirrhosis, whereas 23% (51 22) of our patients developed fibrosis.…”

Section: Discussionsupporting

confidence: 88%

Chronic non‐A, non‐B hepatitis developed after transfusions, illicit self‐injections or sporadically. Outcome during long‐term follow‐up – a comparison

Mattsson

Weiland

Glaumann

1989

Liver

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Ninety-two patients with biopsy-proven chronic non-A, non-B hepatitis after blood transfusions, illicit self-injections or sporadically were followed clinically for an average of nearly 5 years. In the posttransfusion hepatitis group, which comprised 37 patients with a mean age of 54 years (range 18-83 years), 59% developed chronic active hepatitis (CAH) and 46% also showed signs of early cirrhosis (eci) or manifest cirrhosis (Ci). In the illicit self-injection group, comprising 33 patients with a mean age of 26 years (range 17-63 years), 39% manifested CAH and 18% eCi or Ci. In the sporadic group, which consisted of 22 patients with a mean age of 32 years (range 16-62 years), 41% showed CAH and 23% eCi. Thus, in all, 44/92 (48%) of the patients with chronic non-A, non-B hepatitis developed CAH and 28/92 (30%) signs of early or manifest cirrhosis. Patients 2 3 0 years of age displayed CAH and signs of cirrhosis more often than patients < 30 years of age (p < 0.01). Chronic non-A, non-B hepatitis is a slowly progressive disease with a high incidence of cirrhosis, especially in patients 2 30 years of age and when caused by blood transfusion.

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Section: Discussionsupporting

confidence: 88%

Chronic non‐A, non‐B hepatitis developed after transfusions, illicit self‐injections or sporadically. Outcome during long‐term follow‐up – a comparison

Mattsson

Weiland

Glaumann

1989

Liver

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“…Whether the route of transmission is an informative prognostic factor for HCV disease remains controversial. Several adult studies have indicated that transfusion‐associated hepatitis C (TAC) is histologically more severe than hepatitis C from intravenous drug use [15–18]. Furthermore, TAC was more likely than nontransfusion‐associated hepatitis C (non‐TAC) to result in liver failure [19].…”

Section: Introductionmentioning

confidence: 99%

Spontaneous clearance of childhood hepatitis C virus infection

Yeung

King

et al. 2007

Journal of Viral Hepatitis

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To describe the spontaneous clearance rate of childhood hepatitis C virus (HCV) infection, to determine whether route of transmission affects the clearance rate and to identify other predictors of clearance. Children with chronic hepatitis C were identified between 1990 and 2001. The rate of spontaneous clearance (defined as >or=2 positive anti-HCV antibody test but negative HCV RNA) was calculated using survival analysis. Univariate and multivariate predictor variables [route of transmission, age at infection, age at last follow-up, alanine aminotransferase (ALT) and gender] for clearance were evaluated. Of 157 patients, 28% of children cleared infection (34 transfusional and 10 nontransfusional cases). The 123 transfusional cases were older at time of infection and at follow-up, compared with the 34 nontransfusional cases. Younger age at follow-up (p < 0.0001) and normal ALT levels (p < 0.0001) favoured clearance. Among cases of neonatal infection, 25% demonstrated spontaneous clearance by 7.3 years. The rate of spontaneous clearance of childhood HCV infection was comparable between transfusional and nontransfusional cases. If clearance occurs, it tends to occur early in infection, at a younger age.

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Prevalence of antibodies to hepatitis C virus among patients with cryptogenic chronic hepatitis and cirrhosis

et al. 1992

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Many cases of chronic hepatitis and cirrhosis cannot be attributed to a known cause and are collectively referred to as cryptogenic chronic liver disease. We have evaluated the role of the hepatitis C virus in the pathogenesis of this condition in a retrospective serum analysis for antibody to hepatitis C virus in 129 patients with cryptogenic liver disease. Other causes of chronic hepatitis and cirrhosis were ruled out by clinical, serum biochemical and serological techniques. All 129 patients were HBcAg negative, but 28 (22%) had antibody to HBcAg. Sera were tested by radioimmunoassays using recombinant peptides for antibodies to nonstructural (C100-3 and C33c) and structural regions (C22) of HCV. Among the 129 patients, 61 (47%) had antibody to C100-3, 76 (59%) had antibody to C33c and 74 (57%) had antibody to C22. Seventy-nine (61%) were reactive with at least one and 76 (59%) were reactive with at least two HCV peptides (this is the criterion used for hepatitis C virus antibody reactivity). A proportion of patients with chronic hepatitis and cirrhosis (55 of 91; 60%) similar to that of patients without cirrhosis (21 of 38; 55%) had hepatitis C virus antibody. No significant clinical, serum biochemical or histological differences were noted between the group of patients with hepatitis C virus antibody and those without this antibody reactivity. Thus more than half the patients with cryptogenic chronic liver disease had hepatitis C virus antibody, suggesting that chronic HCV infection plays a major role in the origin of cryptogenic chronic hepatitis and cirrhosis.

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Post‐transfusional vs. sporadic non‐A, non‐B chronic hepatitis. A clinico‐pathological and evolutive study

Cited by 19 publications

References 11 publications

Chronic non‐A, non‐B hepatitis developed after transfusions, illicit self‐injections or sporadically. Outcome during long‐term follow‐up – a comparison

Chronic non‐A, non‐B hepatitis developed after transfusions, illicit self‐injections or sporadically. Outcome during long‐term follow‐up – a comparison

Spontaneous clearance of childhood hepatitis C virus infection

Prevalence of antibodies to hepatitis C virus among patients with cryptogenic chronic hepatitis and cirrhosis

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