2020
DOI: 10.1186/s13072-020-00369-1
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Post-translational modifications of PRC2: signals directing its activity

Abstract: Polycomb repressive complex 2 (PRC2) is a chromatin-modifying enzyme that catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex maintains gene transcriptional repression and plays an essential role in the maintenance of cellular identity as well as normal organismal development. The activity of PRC2, including its genomic targeting and catalytic activity, is controlled by various signals. Recent studies have revealed that these signals involve cis chromatin features, PRC2 facultativ… Show more

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Cited by 48 publications
(32 citation statements)
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“…It will also be important to identify the E3 ubiquitin ligase(s) acting on PRC2 in ES cells. Several ligases have been found to ubiquitinate PRC2 in mammalian cells 78 . Our data reinforce that the balance between ubiquitin ligases and deubiquitinases dictates an important layer of PRC2 regulation during peri-implantation development.…”
Section: Discussionmentioning
confidence: 99%
“…It will also be important to identify the E3 ubiquitin ligase(s) acting on PRC2 in ES cells. Several ligases have been found to ubiquitinate PRC2 in mammalian cells 78 . Our data reinforce that the balance between ubiquitin ligases and deubiquitinases dictates an important layer of PRC2 regulation during peri-implantation development.…”
Section: Discussionmentioning
confidence: 99%
“…Beyond the core subunits, PRC2 can have alternate compositions, the core subunits interacting with a different array of proteins [ 35 ]. These proteins and their regulation by phosphorylation have been previously reviewed [ 36 , 37 , 38 , 39 , 40 , 41 , 42 ].…”
Section: Prc2mentioning
confidence: 99%
“…LncRNAs regulate a dual role of EZH2 in PRC2-dependent transcription SUZ12, EZH2 and EED comprise the core components of PRC2 that serves as an epigenetic "writer" to switch off genes [26]. Although H3K27 methylation is an important event to determine gene expression status and cell fate, it remains poorly understood how it is catalyzed by PRC2 in a site-specific manner.…”
Section: Ivyspring International Publishermentioning
confidence: 99%
“…However, if nascent RNAs are quickly transcribed, the pre-existing PRC2 on chromatin can bind G-rich RNAs and be promptly removed from the promoter, leading to reduced H3K27me3 on a targeted promoter and consequent gene activation. Therefore, the decision between recruitment and eviction of PRC2 on a target gene depends on the status of RNAs, including both nascent RNAs and lncRNAs [26,47,105] (Figure 1C). In a study of oncogene-induced senescence, Muniz et al discovered that an isoform of the circular ANRIL could bind to Polycomb proteins and reduce EZH2 occupation on the p15 and p16 promoters, leading to declined H3K27me3.…”
Section: Ivyspring International Publishermentioning
confidence: 99%
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