Post-translational Modifications of Proteins: Biomarkers and Therapeutic Targets for Diabetes Related Complications

Vanuopadath, Muralidharan; Nair, Divya; Nair, Bipin G.; Nair, Sudarslal Sadasivan

doi:10.2174/1570164613666161031155258

Cited by 2 publications

(2 citation statements)

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“…There has been evidence linking methylation, acetylation, glycosylation, and S-nitrosylation to neurological and cardiovascular conditions [94,95]. Diabetes has been linked to dysregulated glycosylation [96]. A significant function for ubiquitination has been identified in a number of uncommon congenital illnesses, including von Hippel-Lindau syndromes [94].…”

Section: Types Of Surface Functionalizationmentioning

confidence: 99%

Tailored Viral-Like Particles as Drivers of Medical Breakthroughs

Travassos,

Martins,

Fernandes

et al. 2024

Preprint

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Despite the recognized potential of nanoparticles, only a few formulations have progressed to clinical trials, and an even smaller number have been approved by the regulatory authorities and marketed. Virus-like particles (VLPs) have emerged as promising alternatives to most explored nanoparticles because of the absence of viral genetic material, their incapacity to replicate, mimicry of viral structure, and tropism conservation. Furthermore, VLPs can be surface functionalized with small molecules to improve circulation half-life and target specificity. Through the functionalization and coating of VLPs, it is possible to optimize the response properties to a given stimulus, such as heat, pH, an alternating magnetic field, or even enzymes. Surface functionalization can also modulate other properties, such as biocompatibility, stability, and specificity, deeming VLPs as potential vaccine candidates or delivery systems. In this review, we address the different types of functionalization of VLPs, their importance, and their consequent biomedical applications.

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Section: Types Of Surface Functionalizationmentioning

confidence: 99%

Tailored Viral-Like Particles as Drivers of Medical Breakthroughs

Travassos,

Martins,

Fernandes

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The Tau protein in Alzheimer’s disease is phosphorylated at forty sites, correlating with disease phases [ 101 ]. Methylation, acetylation, glycosylation, and S-nitrosylation are also linked to neurological and cardiovascular conditions [ 101 , 102 ], while diabetes is associated with dysregulated glycosylation [ 103 ]. Ubiquitination is crucial in rare congenital illnesses such as von Hippel–Lindau syndromes [ 101 ].…”

Section: Types Of Surface Functionalizationmentioning

confidence: 99%

Tailored Viral-like Particles as Drivers of Medical Breakthroughs

Travassos,

Martins,

Fernandes

et al. 2024

IJMS

View full text Add to dashboard Cite

Despite the recognized potential of nanoparticles, only a few formulations have progressed to clinical trials, and an even smaller number have been approved by the regulatory authorities and marketed. Virus-like particles (VLPs) have emerged as promising alternatives to conventional nanoparticles due to their safety, biocompatibility, immunogenicity, structural stability, scalability, and versatility. Furthermore, VLPs can be surface-functionalized with small molecules to improve circulation half-life and target specificity. Through the functionalization and coating of VLPs, it is possible to optimize the response properties to a given stimulus, such as heat, pH, an alternating magnetic field, or even enzymes. Surface functionalization can also modulate other properties, such as biocompatibility, stability, and specificity, deeming VLPs as potential vaccine candidates or delivery systems. This review aims to address the different types of surface functionalization of VLPs, highlighting the more recent cutting-edge technologies that have been explored for the design of tailored VLPs, their importance, and their consequent applicability in the medical field.

show abstract

Post-translational Modifications of Proteins: Biomarkers and Therapeutic Targets for Diabetes Related Complications

Cited by 2 publications

References 0 publications

Tailored Viral-Like Particles as Drivers of Medical Breakthroughs

Tailored Viral-Like Particles as Drivers of Medical Breakthroughs

Tailored Viral-like Particles as Drivers of Medical Breakthroughs

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