Post-translational suppression of the high affinity IgE receptor expression on mast cells by an intestinal bacterium

Fukatsu, Sakino; Horinouchi, Hikari; Nagata, Shiho; Kamei, Risa; Tanaka, Daichi; Hong, Won-Ki; Kazami, Yui; Fujimori, Minami; Itoh, Kazuyoshi; Momose, Yoshika; Kasakura, Kazumi; Hosono, Akira; Kaminogawa, Shuichi; Hanazawa, Shigemasa; Nakanishi, Yusuke; Takahashi, Kyôko

doi:10.1016/j.imbio.2021.152056

Cited by 7 publications

(3 citation statements)

References 39 publications

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“…has been shown to suppress cell surface expression of the high-affinity IgE receptor FcεRI on mast cells important for allergen sensitivity. 68 Moreover, Bacteroides spp. can correct the Th1/Th2 imbalance found in germ-free mice via polysaccharide A-activated dendritic cell signaling.…”

Section: Discussionmentioning

confidence: 99%

Cesarean section induced dysbiosis promotes type 2 immunity but not oxazolone-induced dermatitis in mice

Zachariassen,

Ebert,

Mentzel

et al. 2023

Gut Microbes

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Delivery by cesarean section (CS) is associated with an altered gut microbiota (GM) colonization and a higher risk of later chronic inflammatory diseases. Studies investigating the association between CS and atopic dermatitis (AD) are contradictive and often biased by confounding factors. The aim of this study was therefore to provide experimental evidence for the association between CS and AD in a mouse model and clarify the role of the GM changes associated with CS. It was hypothesized that CS-delivered mice, and human CS-GM transplanted mice develop severe dermatitis due to early dysbiosis. BALB/c mice delivered by CS or vaginally (VD) as well as BALB/c mice transplanted with GM from CS or VD human donors were challenged with oxazolone on the ear. The severity of dermatitis was evaluated by ear thickness and clinical and histopathological assessment which were similar between all groups. The immune response was assessed by serum IgE concentration, local cytokine response, and presence of immune cells in the draining lymph node. Both CS-delivered mice and mice inoculated with human CS-GM had a higher IgE concentration. A higher proportion of Th2 cells were also found in the CS-GM inoculated mice, but no differences were seen in the cytokine levels in the affected ears. In support of the experimental findings, a human cohort analysis from where the GM samples were obtained found that delivery mode did not affect the children’s risk of developing AD. In conclusion, CS-GM enhanced a Th2 biased immune response, but had no effect on oxazolone-induced dermatitis in mice.

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Section: Discussionmentioning

confidence: 99%

Cesarean section induced dysbiosis promotes type 2 immunity but not oxazolone-induced dermatitis in mice

Zachariassen,

Ebert,

Mentzel

et al. 2023

Gut Microbes

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“…B. thetaiotamicron promotes intestinal villus vascularization [76], restores fucosylation [77], stimulates the production of antimicrobial peptides [78], and competes with pathogenic bacteria for food sources [79]. B. acidfaciens is overrepresented in mice resistant to colitis [69,80], prevents IgE receptor expression on mast cells [81], enhances IgA production [82], assists in tumor killing [83], produces vitamin B6, and prevents the colonization of pathogenic bacteria, such as Salmonella [84]. Additionally, it enriched lean mice with healthy lipid profiles and improved insulin sensitivity [85][86][87].…”

Section: Discussionmentioning

confidence: 99%

LACTOCOCCUS LACTIS DELIVERY OF SURFACE LAYER PROTEIN A PROTECTS MICE FROM COLITIS BY RE-SETTING HOST IMMUNE REPERTOIRE

Sahay¹

2022

Inflammatory Bowel Diseases

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Inflammatory bowel disease (IBD) is characterized by gastrointestinal inflammation comprised of Crohn’s disease and ulcerative colitis. Centers for Disease Control and Prevention report that 1.3% of the population of the United States (approximately 3 million people) were affected by the disease in 2015, and the number keeps increasing over time. IBD has a multifactorial etiology, from genetic to environmental factors. Most of the IBD treatments revolve around disease management, by reducing the inflammatory signals. We previously identified the surface layer protein A (SlpA) of Lactobacillus acidophilus that possesses anti-inflammatory properties to mitigate murine colitis. Herein, we expressed SlpA in a clinically relevant, food-grade Lactococcus lactis to further investigate and characterize the protective mechanisms of the actions of SlpA[1] . Oral administration of SlpA-expressing L. lactis (R110) mitigated the symptoms of murine colitis. Oral delivery of R110 resulted in a higher expression of IL-27 by myeloid cells, with a synchronous increase in IL-10 and cMAF in T cells. Consistent with murine studies, human dendritic cells exposed to R110 showed exquisite differential gene regulation, including IL-27 transcription, suggesting a shared mechanism between the two species, hence positioning R110 as potentially effective at treating colitis in humans.

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“…B. thetaiotamicron promotes intestinal villus vascularization [ 76 ], restores fucosylation [ 77 ], stimulates the production of antimicrobial peptides [ 78 ], and competes with pathogenic bacteria for food sources [ 79 ]. B. acidfaciens is overrepresented in mice resistant to colitis [ 69 , 80 ], prevents IgE receptor expression on mast cells [ 81 ], enhances IgA production [ 82 ], assists in tumor killing [ 83 ], produces vitamin B6, and prevents the colonization of pathogenic bacteria, such as Salmonella [ 84 ]. Additionally, it enriched lean mice with healthy lipid profiles and improved insulin sensitivity [ 85 , 86 , 87 ].…”

Section: Discussionmentioning

confidence: 99%

Lactococcus lactis Delivery of Surface Layer Protein A Protects Mice from Colitis by Re-Setting Host Immune Repertoire

Arukha

Freguia²,

Mishra

et al. 2021

Biomedicines

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Inflammatory bowel disease (IBD) is characterized by gastrointestinal inflammation comprised of Crohn’s disease and ulcerative colitis. Centers for Disease Control and Prevention report that 1.3% of the population of the United States (approximately 3 million people) were affected by the disease in 2015, and the number keeps increasing over time. IBD has a multifactorial etiology, from genetic to environmental factors. Most of the IBD treatments revolve around disease management, by reducing the inflammatory signals. We previously identified the surface layer protein A (SlpA) of Lactobacillus acidophilus that possesses anti-inflammatory properties to mitigate murine colitis. Herein, we expressed SlpA in a clinically relevant, food-grade Lactococcus lactis to further investigate and characterize the protective mechanisms of the actions of SlpA. Oral administration of SlpA-expressing L. lactis (R110) mitigated the symptoms of murine colitis. Oral delivery of R110 resulted in a higher expression of IL-27 by myeloid cells, with a synchronous increase in IL-10 and cMAF in T cells. Consistent with murine studies, human dendritic cells exposed to R110 showed exquisite differential gene regulation, including IL-27 transcription, suggesting a shared mechanism between the two species, hence positioning R110 as potentially effective at treating colitis in humans.

show abstract

Post-translational suppression of the high affinity IgE receptor expression on mast cells by an intestinal bacterium

Cited by 7 publications

References 39 publications

Cesarean section induced dysbiosis promotes type 2 immunity but not oxazolone-induced dermatitis in mice

Cesarean section induced dysbiosis promotes type 2 immunity but not oxazolone-induced dermatitis in mice

LACTOCOCCUS LACTIS DELIVERY OF SURFACE LAYER PROTEIN A PROTECTS MICE FROM COLITIS BY RE-SETTING HOST IMMUNE REPERTOIRE

Lactococcus lactis Delivery of Surface Layer Protein A Protects Mice from Colitis by Re-Setting Host Immune Repertoire

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