2020
DOI: 10.3748/wjg.v26.i21.2740
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Post-transplant diabetes mellitus and preexisting liver disease - a bidirectional relationship affecting treatment and management

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Cited by 16 publications
(14 citation statements)
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“…To confirm this, our data showed significant increases in the levels of renal function parameters (urea, creatinine, uric acid, and eGFR) along with significant correlations between the two groups [47]. Other diabetic complications include liver injury, fatty liver, and cirrhosis [48]. Meanwhile, levels of ALT, AST, and ALP are also correlated with UII positively in the present study.…”
Section: Discussionsupporting
confidence: 81%
“…To confirm this, our data showed significant increases in the levels of renal function parameters (urea, creatinine, uric acid, and eGFR) along with significant correlations between the two groups [47]. Other diabetic complications include liver injury, fatty liver, and cirrhosis [48]. Meanwhile, levels of ALT, AST, and ALP are also correlated with UII positively in the present study.…”
Section: Discussionsupporting
confidence: 81%
“…Cleary, PTDM is an emerging problem among liver transplant recipients, and optimal treatment modalities have not yet been identified[ 55 , 56 ]. In our literature search, we did not identify prospective trials investigating safety and efficacy of SGLT2-inhibitors in liver transplant recipients.…”
Section: Potential Risks Of Sglt2-inhibitorsmentioning
confidence: 99%
“…Finally, timely treatment of manifest PTDM is recommended, with novel antidiabetic substances such as SGLT2 inhibitors bearing the potential to target both glucose metabolism and cardiovascular and renal outcomes, albeit no data for post-LTx are available so far. Whether all these measures will result in improved patient and allograft survival after LTx, however, has yet to be determined [48].…”
Section: Discussionmentioning
confidence: 99%
“…Of these, 199 patients (61%) were male, and 128 (39%) were female. Median age at time of transplantation was 54 [45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61] years. Common primary diseases leading to LTx were alcoholic liver disease (26%), chronic viral hepatitis C (20%) or B (8%), cholestatic liver diseases (12%), acute liver failure (8%), and cryptogenic liver disease (5%).…”
Section: Patient Characteristicsmentioning
confidence: 99%