2018
DOI: 10.1111/nep.13281
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Post‐transplant immunoglobulin A deposition and nephropathy in allografts

Abstract: Post-transplant immunoglobulin A (IgA) nephropathy (IgAN) in the allograft is the major cause of allograft loss. Using a protocol biopsy, latent mesangial IgA deposition (IgAD) can be detected in the allograft. Latent IgAD is distinguished from IgAN by the absence of urinary abnormalities, although IgA is observed in the mesangium. However, the pathophysiology and most appropriate treatment strategy for latent mesangial IgAD in the allograft remain to be fully determined. Importantly, it is unknown whether all… Show more

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Cited by 8 publications
(8 citation statements)
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“…However, the rate of recurrence seems to be time-dependent, progressively increasing after transplantation [ 49 ]. Younger age at renal transplantation, recipients of zero-HLA mismatched live-related donor kidney, steroid-avoidance or early steroid-withdrawal immunosuppressive regimens, male gender, rapidly progressive course of the original disease before transplantation, degree of proteinuria, HLA-B35/DR4, and higher levels of circulating Gd-IgA1 and IgA-IgG immune complexes are all probably associated with a higher risk of recurrence [ 50 , 51 ]. Several molecules, such as soluble CD89, may be related to an increased risk of disease progression and of recurrence after transplantation [ 52 ].…”
Section: Primary Gn Iga Nephropathy (Igan)mentioning
confidence: 99%
“…However, the rate of recurrence seems to be time-dependent, progressively increasing after transplantation [ 49 ]. Younger age at renal transplantation, recipients of zero-HLA mismatched live-related donor kidney, steroid-avoidance or early steroid-withdrawal immunosuppressive regimens, male gender, rapidly progressive course of the original disease before transplantation, degree of proteinuria, HLA-B35/DR4, and higher levels of circulating Gd-IgA1 and IgA-IgG immune complexes are all probably associated with a higher risk of recurrence [ 50 , 51 ]. Several molecules, such as soluble CD89, may be related to an increased risk of disease progression and of recurrence after transplantation [ 52 ].…”
Section: Primary Gn Iga Nephropathy (Igan)mentioning
confidence: 99%
“…It is important to note that data on recurrence rates of IgAN on kidney transplants vary due to differences in the screening programs (indication kidney graft biopsy vs. surveillance kidney graft biopsy). Results from indication kidney graft biopsy report that IgAN recurrence can occur in 13% to 50% of recipients [4], while results of surveillance biopsy report IgAN recurrence in up to 60% recipients [5] and in Asian populations even in 70% recipients [6].…”
Section: Introductionmentioning
confidence: 99%
“…S5 Furthermore, codeposition of C3 and IgG accompanied by IgA deposition is considered to be an indicator of progression from IgA deposition to IgAN. 8 In the report by Gaber et al, only 9.1% of donated kidneys with IgA deposition had codeposition of IgG. In contrast, another recent study of symptomatic IgAN in the native kidney detected IgG antibodies against galactose-deficient IgA1 in samples using confocal immunofluorescence microscopy, even in kidneys negative for IgG by routine immunofluorescence.…”
Section: See Clinical Research On Page 1914mentioning
confidence: 90%
“…[1][2][3][4][5][6] Latent mesangial IgA deposition, determined as mesangial IgA deposition detected by immunofluorescence microscopy and paramesangial dense deposits detected by electron microscopy, 1 is distinguished from IgAN by the absence of proteinuria or hematuria. 7,8 Asymptomatic latent IgA deposition has been reported in 13%-29% of kidneys donated by Asian living donors 1,[3][4][5][6] ; however, the precise prevalence in an ethnically diverse US population is unknown.…”
Section: See Clinical Research On Page 1914mentioning
confidence: 99%