Post-Transplant Lymphocyte-to-Monocyte Ratio (LMR) Predicts Survival in Myeloma Patients Undergoing Autologous Transplant

Age barriers in allogeneic hematopoietic cell transplantation: Raising the silver curtain

“…103,104 However, one analysis of the utility of HCT-CI in an exclusively older population did not find an association with OS or NRM, which may be in part due to the commonality of comorbidities in older adults. 65 Similarly, in a recent publication in patients 60 years and older, HCT-CI score was not associated with survival or NRM, with NRM being 36% in low-risk HCT-CI, 31% in intermediate-risk, and 33% in high-risk patients by HCT-CI. 105 Modern HCT approaches, such as GVHD prophylaxis with PTCy, may lessen the risk of NRM for patients with comorbidities and novel scoring systems may be necessary to risk stratify patients with modern HCT platforms.…”

“…Being frail at 1 and 6 months after HCT is associated with inferior 12-month overall survival. 65 As a result of this work, we now have an ongoing pre-habilitation and rehabilitation clinical study to determine the feasibility and efficacy of improving frailty status with supervised exercise interventions (NCT05612789).…”

“…67 In HCT, gait speed and timed up and go have been demonstrated to be associated with OS, but with lack of widespread adoption in the clinical space. 56,65,68,69 Other metrics such as weight loss, 70 patient-reported outcomes (PROs), including the Lawton Independent Activities of Daily Living Scale (IADL) and medical outcomes study physical health scale (MOS-PH), have also been associated with OS after HCT and have the benefit of not requiring health care providers to adminster the testing. 55,71 The Katz Activity of Daily Living (ADL) or OARS multidimensional functional assessment questionnaire (OMFAQ) 72 may also improve risk stratification of older adults and, given they are completed by patients in under 15 minutes, may not have the barriers to implementation inherent to cGA.…”