Post‐transplant lymphoproliferative disease in children, adolescents, and young adults

Abstract

Post-transplant lymphoproliferative disease (PTLD) remains a major complication of transplantation. PTLD is a rare entity and very heterogenous making consensus on diagnosis and treatment very challenging. The majority are Epstein-Barr virus (EBV) driven, CD20+ B-cell proliferations. PTLD does occur following hematopoietic stem cell transplant (HSCT), but due to the relative short risk period and efficacy of preemptive therapy, PTLD following HSCT will not be discussed in this review. This review will focus on the epidemiology, role of EBV, clinical presentation, diagnosis and evaluation and the current and emerging treatment strategies for pediatric PTLD following solid organ transplantation.

Lacrimal Gland Posttransplant Lymphoproliferative Disorder in Children: The First Case Report

“…The clinical presentation of PTLD is quite variable but the involvement of the ocular and ocular adnexa (eyelid, conjunctiva, orbit, lacrimal gland, and lacrimal sac) is exceedingly rare. 1 We describe this first case of lacrimal gland PTLD highlighting this variety of presentation occurring after pediatric transplantation.…”