Post-transplantation outcome in non-alcoholic steatohepatitis cirrhosis: Comparison with alcoholic cirrhosis

Hepatocellular carcinoma in patients with non-alcoholic steatohepatitis – epidemiology, risk factors, clinical implications and treatment

“…For these reasons, the majority of patients with HCC in the course of NAFLD have liver resection procedures, and only a small fraction of patients are eligible for LTx [ 24 , 30 ]. Three- and 5-year survival of patients with NAFLD from the time of LTx does not significantly differ from the results of liver transplantation from other reasons [ 15 , 59 , 62 - 64 ]. The fact remains that in the first two years from the time of LTx, the main causes of death are IVD, sepsis, and severe obesity [ 15 , 59 , 63 ].…”

Mechanisms of nonalcoholic fatty liver disease and implications for surgery

“…Interestingly, post-transplant survival was shown to be higher compared with HCV-associated LT whereas no difference was seen between NASH-associated and alcoholic liver disease-related LT [90,91]. When comparing the results of HCC related LT, no difference was found between NASH-and non-NASH-associated HCC-related LT. Rather, there was a trend towards a favorable outcome for NASH-associated HCC-related LT [87,89]. The prevalence of HCC in NASH-associated LT was higher compared with non-NASH-associated LT [78,87,88].…”

“…The shortand long-term results examined in various studies was similar between NAFLD/NASH and non-NAFLD/NASH, including alcoholic liver disease, HBV, cryptogenic cirrhosis, and primary biliary cholangitis/primary sclerosing cholangitis (PBC/PSC). Remarkably, overall survival showed no significant difference [77,78,[86][87][88][89][90]. Interestingly, post-transplant survival was shown to be higher compared with HCV-associated LT whereas no difference was seen between NASH-associated and alcoholic liver disease-related LT [90,91].…”

“…As discussed in this review, NAFLD patients on the waiting list for LT are more likely to present with obesity, older age, higher cardiovascular risk, and metabolic comorbidities. While the presence of higher peri-/postoperative complication rates in NAFLD patients, mainly cardiovascular events and mortality, remain controversial, long-term postoperative mortality showed no difference between NAFLD/NASH and non-NAFLD/NASH-related LT [57,59,78,[86][87][88]. The shortand long-term results examined in various studies was similar between NAFLD/NASH and non-NAFLD/NASH, including alcoholic liver disease, HBV, cryptogenic cirrhosis, and primary biliary cholangitis/primary sclerosing cholangitis (PBC/PSC).…”

A blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in advanced liver fibrosis

“…PLSec-AFP was well calibrated over time (Figure 2E) and showed robust prognostic association after adjustment for other clinical variables (Table S3). Subgroup analyses suggested enhanced magnitude of association in patients with early-stage (i.e., compensated) liver disease (Child-Pugh class A) as well as NAFLD or cryptogenic etiology (often associated with history of NAFLD 19 ), a patient population with the greatest need for HCC risk stratification (Figure 2F). We observed modest prognostic association in patients with active HCV infection, a vanishing population with widespread use of direct-acting antivirals (DAAs).…”